{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T21:17:34Z","timestamp":1791235054169,"version":"4.1.0"},"reference-count":70,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2013,10,7]],"date-time":"2013-10-07T00:00:00Z","timestamp":1381104000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Ministry of Education, Science and Culture of Japan","award":["20591918"],"award-info":[{"award-number":["20591918"]}]},{"name":"Ministry of Education, Science and Culture of Japan","award":["21592099"],"award-info":[{"award-number":["21592099"]}]},{"name":"Ministry of Education, Science and Culture of Japan","award":["21791559"],"award-info":[{"award-number":["21791559"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Obstet and Gynaecol"],"published-print":{"date-parts":[[2014,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Melatonin (\n                    <jats:styled-content style=\"fixed-case\">N<\/jats:styled-content>\n                    \u2010acetyl\u20105\u2010methoxytryptamine) is secreted during the dark hours at night by the pineal gland. After entering the circulation, melatonin acts as an endocrine factor and a chemical messenger of light and darkness. It regulates a variety of important central and peripheral actions related to circadian rhythms and reproduction. It also affects the brain, immune, gastrointestinal, cardiovascular, renal, bone and endocrine functions and acts as an oncostatic and anti\u2010aging molecule. Many of melatonin's actions are mediated through interactions with specific membrane\u2010bound receptors expressed not only in the central nervous system, but also in peripheral tissues. Melatonin also acts through non\u2010receptor\u2010mediated mechanisms, for example serving as a scavenger for reactive oxygen species and reactive nitrogen species. At both physiological and pharmacological concentrations, melatonin attenuates and counteracts oxidative stress and regulates cellular metabolism. Growing scientific evidence of reproductive physiology supports the role of melatonin in human reproduction. This review was conducted to investigate the effects of melatonin on female reproduction and to summarize our findings in this field.\n                  <\/jats:p>","DOI":"10.1111\/jog.12177","type":"journal-article","created":{"date-parts":[[2013,10,11]],"date-time":"2013-10-11T22:45:54Z","timestamp":1381531554000},"page":"1-11","source":"Crossref","is-referenced-by-count":129,"title":["Melatonin and female reproduction"],"prefix":"10.1111","volume":"40","author":[{"given":"Hiroshi","family":"Tamura","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology Yamaguchi University Graduate School of Medicine Ube Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akihisa","family":"Takasaki","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Saiseikai Shimonoseki General Hospital Shimonoseki Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toshiaki","family":"Taketani","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Yamaguchi University Graduate School of Medicine Ube Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manabu","family":"Tanabe","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Yamaguchi University Graduate School of Medicine Ube Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lifa","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Yamaguchi University Graduate School of Medicine Ube Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isao","family":"Tamura","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Yamaguchi University Graduate School of Medicine Ube Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryo","family":"Maekawa","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Yamaguchi University Graduate School of Medicine Ube Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiromi","family":"Aasada","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Yamaguchi University Graduate School of Medicine Ube Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshiaki","family":"Yamagata","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Yamaguchi University Graduate School of Medicine Ube Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Norihiro","family":"Sugino","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Yamaguchi University Graduate School of Medicine Ube Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2013,10,7]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-079X.2008.00635.x"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-079X.2008.00561.x"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11154-009-9117-5"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-079X.2006.00407.x"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1210\/jcem-66-3-648"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mce.2012.01.004"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mce.2012.04.009"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.2478\/v10039-008-0032-x"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.2174\/092986710791233689"},{"key":"e_1_2_11_11_1","first-page":"269","article-title":"The photoperiod, circadian regulation and chronodisruption: The requisite interplay between the suprachiasmatic nuclei and the pineal and gut melatonin","volume":"62","author":"Reiter RJ","year":"2011","journal-title":"J Physiol Pharmacol"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.R600036200"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1159\/000081966"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10620-007-0195-5"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/s007020050208"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1748-1716.1985.tb07676.x"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1439-0272.1989.tb02456.x"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1210\/jcem-69-5-1065"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1210\/jcem-64-4-865"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.92.19.8734"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1385\/ENDO:27:2:101"},{"issue":"1","key":"e_1_2_11_22_1","doi-asserted-by":"crossref","first-page":"S153","DOI":"10.33549\/physiolres.930000.53.S153","article-title":"Melatonin action in neonatal gonadotrophs","volume":"53","author":"Balik A","year":"2004","journal-title":"Physiol Res"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00441-002-0581-4"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-079X.2004.00207.x"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2002-020449"},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.1210\/jcem.86.10.7912"},{"key":"e_1_2_11_27_1","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00018.2001"},{"key":"e_1_2_11_28_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-079X.2010.00759.x"},{"key":"e_1_2_11_29_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-079X.2004.00181.x"},{"key":"e_1_2_11_30_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-079X.2009.00715.x"},{"key":"e_1_2_11_31_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-079X.2009.00687.x"},{"key":"e_1_2_11_32_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-079X.2008.00656.x"},{"key":"e_1_2_11_33_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-079X.2007.00490.x"},{"key":"e_1_2_11_34_1","doi-asserted-by":"publisher","DOI":"10.1385\/CBB:34:2:237"},{"key":"e_1_2_11_35_1","doi-asserted-by":"publisher","DOI":"10.1007\/PL00012498"},{"key":"e_1_2_11_36_1","doi-asserted-by":"publisher","DOI":"10.1095\/biolreprod50.2.233"},{"key":"e_1_2_11_37_1","doi-asserted-by":"publisher","DOI":"10.1186\/1477-7827-3-28"},{"key":"e_1_2_11_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1071-5576(00)00106-4"},{"key":"e_1_2_11_39_1","doi-asserted-by":"publisher","DOI":"10.1210\/endo-128-6-2958"},{"key":"e_1_2_11_40_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrd.1080280408"},{"key":"e_1_2_11_41_1","doi-asserted-by":"publisher","DOI":"10.1095\/biolreprod57.6.1413"},{"key":"e_1_2_11_42_1","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/13.4.998"},{"key":"e_1_2_11_43_1","doi-asserted-by":"publisher","DOI":"10.1210\/jcem-71-2-493"},{"key":"e_1_2_11_44_1","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1016\/S0022-3565(25)26732-5","article-title":"The uptake of H3\u2010melatonin in endocrine and nervous tissues and the effects of constant light exposure","volume":"143","author":"Wurtman RJ","year":"1964","journal-title":"J Pharmacol Exp Ther"},{"key":"e_1_2_11_45_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-079X.1998.tb00551.x"},{"key":"e_1_2_11_46_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0015-0282(03)01008-2"},{"key":"e_1_2_11_47_1","doi-asserted-by":"publisher","DOI":"10.1023\/A:1020107915919"},{"key":"e_1_2_11_48_1","doi-asserted-by":"publisher","DOI":"10.1096\/fj.01-0952fje"},{"key":"e_1_2_11_49_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-079X.2000.280401.x"},{"key":"e_1_2_11_50_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-079X.2011.00878.x"},{"key":"e_1_2_11_51_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-079X.2007.00524.x"},{"key":"e_1_2_11_52_1","doi-asserted-by":"publisher","DOI":"10.1186\/1757-2215-5-5"},{"key":"e_1_2_11_53_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2008.05.016"},{"key":"e_1_2_11_54_1","doi-asserted-by":"publisher","DOI":"10.1186\/1757-2215-2-1"},{"key":"e_1_2_11_55_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2007.10.056"},{"key":"e_1_2_11_56_1","doi-asserted-by":"publisher","DOI":"10.1053\/smrv.2002.0243"},{"key":"e_1_2_11_57_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.1985.tb11808.x"},{"issue":"6","key":"e_1_2_11_58_1","first-page":"E799","article-title":"Melatonin rhythms in fetal and maternal circulation during pregnancy in sheep","volume":"252","author":"Yellon SM","year":"1987","journal-title":"Am J Physiol"},{"key":"e_1_2_11_59_1","doi-asserted-by":"publisher","DOI":"10.1080\/01443619750112411"},{"key":"e_1_2_11_60_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-079X.2001.300104.x"},{"key":"e_1_2_11_61_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-079X.2007.00537.x"},{"key":"e_1_2_11_62_1","doi-asserted-by":"publisher","DOI":"10.1507\/endocrj.50.37"},{"key":"e_1_2_11_63_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.reprotox.2008.03.005"},{"key":"e_1_2_11_64_1","doi-asserted-by":"publisher","DOI":"10.1016\/0049-3848(96)00143-0"},{"key":"e_1_2_11_65_1","doi-asserted-by":"publisher","DOI":"10.1016\/0378-5122(90)90012-U"},{"key":"e_1_2_11_66_1","doi-asserted-by":"publisher","DOI":"10.1016\/0021-9150(88)90023-8"},{"key":"e_1_2_11_67_1","first-page":"613","article-title":"Anti\u2010hypercholesterolemic effect of melatonin in rats","volume":"39","author":"Mori N","year":"1989","journal-title":"Acta Pathol Jpn"},{"key":"e_1_2_11_68_1","doi-asserted-by":"publisher","DOI":"10.1080\/07435809509030483"},{"key":"e_1_2_11_69_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-079X.2010.00835.x"},{"key":"e_1_2_11_70_1","first-page":"35","article-title":"The effects of long\u2010term melatonin treatment on plasma liver enzymes levels and plasma concentrations of lipids and melatonin in patients with nonalcoholic steatohepatitis: A pilot study","volume":"63","author":"Gonciarz M","year":"2012","journal-title":"J Physiol Pharmacol"},{"key":"e_1_2_11_71_1","first-page":"577","article-title":"The effects of L\u2010tryptophan and melatonin on selected biochemical parameters in patients with steatohepatitis","volume":"61","author":"Cichoz\u2010Lach H","year":"2010","journal-title":"J Physiol Pharmacol"}],"container-title":["Journal of Obstetrics and Gynaecology Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjog.12177","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjog.12177","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jog.12177","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,30]],"date-time":"2025-04-30T12:48:02Z","timestamp":1746017282000},"score":1,"resource":{"primary":{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/10.1111\/jog.12177"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,10,7]]},"references-count":70,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2014,1]]}},"alternative-id":["10.1111\/jog.12177"],"URL":"https:\/\/doi.org\/10.1111\/jog.12177","archive":["Portico"],"relation":{},"ISSN":["1341-8076","1447-0756"],"issn-type":[{"value":"1341-8076","type":"print"},{"value":"1447-0756","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,10,7]]}}}