{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T08:27:53Z","timestamp":1740126473568,"version":"3.37.3"},"reference-count":18,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2013,10,11]],"date-time":"2013-10-11T00:00:00Z","timestamp":1381449600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100009592","name":"Beijing Municipal Science and Technology Commission","doi-asserted-by":"crossref","award":["D0906008040391"],"award-info":[{"award-number":["D0906008040391"]}],"id":[{"id":"10.13039\/501100009592","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Obstet and Gynaecol"],"published-print":{"date-parts":[[2014,2]]},"abstract":"Abstract<\/jats:title>Aim<\/jats:title>\u2002To investigate the relationship between cervical intraepithelial neoplasia (CIN<\/jats:styled-content>) and high\u2010risk human papilloma virus (HR\u2010HPV<\/jats:styled-content>) during pregnancy and postpartum in C<\/jats:styled-content>hina.<\/jats:p><\/jats:sec>Methods<\/jats:title>In this prospective case\u2013control study, 168 pregnant women with CIN<\/jats:styled-content> and cervicitis were diagnosed by colposcopic cervical biopsy. All the cases underwent hybrid capture assay version II (HC<\/jats:styled-content>II) to detect HR\u2010HPV DNA load amounts and the tests were completed in 3\u20136 months after childbirth.<\/jats:p><\/jats:sec>Results<\/jats:title>During pregnancy: as the CIN<\/jats:styled-content> grade increased, the HR\u2010HPV<\/jats:styled-content> infection rates increased (P<\/jats:styled-content><\/jats:italic>\u2009=\u20090.002), but HR\u2010HPV DNA load amounts (in logarithms) did not change obviously (P<\/jats:styled-content><\/jats:italic>\u2009=\u20090.719). 3\u20136 months postpartum: as the CIN<\/jats:styled-content> grade increased, the natural negative rate of HR\u2010HPV<\/jats:styled-content> decreased (P<\/jats:styled-content><\/jats:italic>\u2009=\u20090.000), while the amount of HR\u2010HPV DNA<\/jats:styled-content> (in logarithms) increased (P<\/jats:styled-content><\/jats:italic>\u2009=\u20090.036); especially the amount of HR\u2010HPV DNA in pregnant women with CIN<\/jats:styled-content>III was significantly higher than that of other grades. During pregnancy and 3\u20136 months postpartum : the amount of HR\u2010HPV DNA<\/jats:styled-content> (in logarithms) during pregnancy was higher than that of 3\u20136 months postpartum with the same grade of CIN<\/jats:styled-content>.<\/jats:p><\/jats:sec>Conclusion<\/jats:title>The findings emphasize the importance of undergoing the HC<\/jats:styled-content>II test 3\u20136 months postpartum. It should be noted that HR\u2010HPV<\/jats:styled-content> may turn negative in pregnancy with CIN<\/jats:styled-content>III 3\u20136 months after childbirth. Further treatments of pregnancy with CIN<\/jats:styled-content> should be considered according to the CIN<\/jats:styled-content> grade diagnosed by cervical biopsy via colposcopy 3\u20136 months after birth, but not according to the persistence of HR\u2010HPV<\/jats:styled-content> during pregnancy.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jog.12192","type":"journal-article","created":{"date-parts":[[2013,10,14]],"date-time":"2013-10-14T11:49:12Z","timestamp":1381751352000},"page":"538-544","source":"Crossref","is-referenced-by-count":1,"title":["High\u2010risk human papilloma virus management in pregnancy with cervical intraepithelial neoplasia during pregnancy and postpartum in C<\/scp>hina"],"prefix":"10.1111","volume":"40","author":[{"given":"Yue","family":"He","sequence":"first","affiliation":[{"name":"Department of Gynecologic Oncology Beijing Obstetrics and Gynecology Hospital Capital Medical University Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yu\u2010Mei","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Gynecologic Oncology Beijing Obstetrics and Gynecology Hospital Capital Medical University Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qun","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Gynecologic Oncology Beijing Obstetrics and Gynecology Hospital Capital Medical University Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tong","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Gynecologic Oncology Beijing Obstetrics and Gynecology Hospital Capital Medical University Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fang","family":"Song","sequence":"additional","affiliation":[{"name":"Department of Gynecologic Oncology Beijing Obstetrics and Gynecology Hospital Capital Medical University Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Li","family":"Zhu","sequence":"additional","affiliation":[{"name":"Department of Pathology Beijing Obstetrics and Gynecology Hospital Capital Medical University Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2013,10,11]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.ogx.0000221011.01750.25"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1447-0756.2012.01977.x"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/LGT.0b013e318159408b"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1258\/jms.2012.012081"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.287.16.2114"},{"key":"e_1_2_5_7_1","first-page":"105, 107, 313","volume-title":"Lin Qiao\u2010Zhi Gynecologic Oncology","author":"Lian 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