{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,20]],"date-time":"2026-05-20T17:12:54Z","timestamp":1779297174747,"version":"3.51.4"},"reference-count":19,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2013,10,11]],"date-time":"2013-10-11T00:00:00Z","timestamp":1381449600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Obstet and Gynaecol"],"published-print":{"date-parts":[[2014,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>The purpose of our study was to evaluate the efficacy of laser ablation as a conservative treatment for cervical intraepithelial neoplasia 3 (<jats:styled-content style=\"fixed-case\">CIN<\/jats:styled-content>3) and assess whether the human papillomavirus (<jats:styled-content style=\"fixed-case\">HPV<\/jats:styled-content>) test is useful to predict recurrence after treatment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>A total of 134 patients who received laser ablation for treatment of <jats:styled-content style=\"fixed-case\">CIN<\/jats:styled-content>3 were enrolled in this study. During the follow\u2010up period, patients were followed with cytological and colposcopic evaluations. Recurrence of <jats:styled-content style=\"fixed-case\">CIN<\/jats:styled-content>3 was regarded as the primary end\u2010point. <jats:styled-content style=\"fixed-case\">HPV<\/jats:styled-content> genotype was tested before and after treatment. Post\u2010treatment cumulative recurrence rates were estimated and comparisons by both patient age and <jats:styled-content style=\"fixed-case\">HPV<\/jats:styled-content> genotype were performed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Overall cumulative recurrence rate of <jats:styled-content style=\"fixed-case\">CIN<\/jats:styled-content>3 in the first year after treatment was 22.6% for all patients. No significant correlation was shown between patient age and recurrence. Patients infected by specific genotypes (16, 18, 31, 33, 52, and 58) frequently failed to clear the infection after treatment. The 1\u2010year recurrence\u2010free survival in those positive after treatment for eight high\u2010risk genotypes (16, 18, 31, 33, 35, 45, 52, and 58) was significantly lower (66.7%), compared to that in those positive for other high\u2010risk types (78.6%). The recurrence\u2010free survival of those who remained <jats:styled-content style=\"fixed-case\">HPV<\/jats:styled-content>\u2010positive after treatment was significantly lower than those who turned negative.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Laser ablation should be performed prudently with appropriate patient counseling about recurrence rate. Considering its minimal invasiveness, laser ablation is effective, especially for young patients who are negative for eight high\u2010risk genotypes. With regard to <jats:styled-content style=\"fixed-case\">HPV<\/jats:styled-content> testing, although genotyping has significant value for predicting recurrence, screening for all genotypes warrants further evaluation.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jog.12196","type":"journal-article","created":{"date-parts":[[2013,10,14]],"date-time":"2013-10-14T11:57:44Z","timestamp":1381751864000},"page":"554-560","source":"Crossref","is-referenced-by-count":8,"title":["High\u2010risk human papillomavirus correlates with recurrence after laser ablation for treatment of patients with cervical intraepithelial neoplasia 3: A long\u2010term follow\u2010up retrospective study"],"prefix":"10.1111","volume":"40","author":[{"given":"Kanako","family":"Inaba","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology Faculty of Medicine The University of Tokyo  Tokyo 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