{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T06:49:26Z","timestamp":1790837366373,"version":"4.1.0"},"reference-count":24,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2013,10,22]],"date-time":"2013-10-22T00:00:00Z","timestamp":1382400000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Roche Diagnostics K.K., Tokyo, Japan"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Obstet and Gynaecol"],"published-print":{"date-parts":[[2014,2]]},"abstract":"Abstract<\/jats:title>Aim<\/jats:title>Few studies have examined the effect of combined low\u2010risk human papillomavirus (LR\u2010HPV<\/jats:styled-content>) and high\u2010risk human papillomavirus (HR\u2010HPV<\/jats:styled-content>) infection on the progression of cervical intraepithelial neoplasia (CIN<\/jats:styled-content>)2 to CIN3<\/jats:styled-content>. This multi\u2010institutional prospective cohort study investigated the risk of progression of CIN2<\/jats:styled-content> with various combinations of HR\u2010HPV<\/jats:styled-content> and LR\u2010HPV<\/jats:styled-content> infection.<\/jats:p><\/jats:sec>Methods<\/jats:title>Between J<\/jats:styled-content>anuary 2007 and M<\/jats:styled-content>ay 2008, 122 women with CIN2<\/jats:styled-content> (aged 20\u201350\u2009years) from 24 hospitals throughout J<\/jats:styled-content>apan were enrolled in the study. Ninety\u2010three women were analyzed after a 2\u2010year follow\u2010up with cytology, colposcopy, HR\u2010HPV<\/jats:styled-content> testing and HPV<\/jats:styled-content> genotyping. Colposcopy\u2010directed biopsy was performed at entry and the end of this study, or when disease progression was suspected.<\/jats:p><\/jats:sec>Results<\/jats:title>Among 93 women with CIN2<\/jats:styled-content>, 87 (93.5%) had HR\u2010HPV<\/jats:styled-content> infection. Among these 87 cases, 24 (27.6%) progressed to CIN3<\/jats:styled-content> and 49 (56.3%) regressed. None of the six women with CIN2<\/jats:styled-content> without HR\u2010HPV<\/jats:styled-content> infection progressed. The progression rate was significantly lower in women with combined HR\u2010HPV<\/jats:styled-content> and LR\u2010HPV<\/jats:styled-content> infection (3\/28, 10.7%) than in those with HR\u2010HPV<\/jats:styled-content> infection only (21\/59, 35.6%; P<\/jats:styled-content><\/jats:italic>\u2009=\u20090.016). Multivariate analyses showed that CIN2<\/jats:styled-content> progression in women with HR\u2010HPV<\/jats:styled-content> infection was negatively associated with LR\u2010HPV<\/jats:styled-content> co\u2010infection (hazard ratio\u2009=\u20090.152; 95% confidence interval [CI<\/jats:styled-content>]\u2009=\u20090.042\u20130.553). CIN2<\/jats:styled-content> regression was positively associated with LR\u2010HPV<\/jats:styled-content> co\u2010infection (odds ratio\u2009=\u20094.553; 95% CI<\/jats:styled-content>\u2009=\u20091.378\u201315.039).<\/jats:p><\/jats:sec>Conclusion<\/jats:title>The risk of CIN2<\/jats:styled-content> progression is low in women with combined infection of HR\u2010HPV<\/jats:styled-content> and LR\u2010HPV<\/jats:styled-content>. The finding may be useful for management of women diagnosed with CIN2<\/jats:styled-content>.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jog.12202","type":"journal-article","created":{"date-parts":[[2013,10,22]],"date-time":"2013-10-22T08:02:28Z","timestamp":1382428948000},"page":"561-569","source":"Crossref","is-referenced-by-count":16,"title":["Potential impact of combined high\u2010 and low\u2010risk human papillomavirus infection on the progression of cervical intraepithelial neoplasia 2"],"prefix":"10.1111","volume":"40","author":[{"given":"Masao","family":"Okadome","sequence":"first","affiliation":[{"name":"Gynecology Service National Kyushu Cancer Center Fukuoka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toshiaki","family":"Saito","sequence":"additional","affiliation":[{"name":"Gynecology Service National Kyushu Cancer Center Fukuoka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hideyuki","family":"Tanaka","sequence":"additional","affiliation":[{"name":"Roche Diagnostics K.K. Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takayoshi","family":"Nogawa","sequence":"additional","affiliation":[{"name":"Department of Gynecology National Hospital Organization Shikoku Cancer Center Ehime Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Reiko","family":"Furuta","sequence":"additional","affiliation":[{"name":"Department of Pathology The Cancer Institute of the Japanese Foundation for Cancer Research Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kayoko","family":"Watanabe","sequence":"additional","affiliation":[{"name":"Roche Diagnostics K.K. Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tsunekazu","family":"Kita","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Nara Prefectural Nara Hospital Nara Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kaichiro","family":"Yamamoto","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Faculty of Medicine Sakai Hospital Kinki University Osaka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mikio","family":"Mikami","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Tokai University Hospital Isehara Kanagawa Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ken","family":"Takizawa","sequence":"additional","affiliation":[{"name":"Department of Gynecology The Cancer Institute Hospital of the Japanese Foundation for Cancer Research Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"Japanese Gynecologic Oncology Group (JGOG)","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2013,10,22]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2004.06.088"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/0304-419X(96)00020-0"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.25630"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/00004347-199304000-00018"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0029-7844(98)00245-2"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/91.3.252"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2007.07.049"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/AOG.0b013e31818f5008"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/djq356"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.virol.2005.04.002"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(10)70230-8"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/dji187"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1086\/507909"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1158\/1055-9965.EPI-06-0129"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1086\/428850"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1136\/jcp.2004.022863"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0215(19990315)80:6<818::AID-IJC4>3.0.CO;2-T"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1099\/0022-1317-80-11-2931"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1086\/315086"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.73.7.6188-6190.1999"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1186\/1479-5876-8-28"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjc.6601024"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1097\/pgp.0b013e31805152ab"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.11216"}],"container-title":["Journal of Obstetrics and Gynaecology Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjog.12202","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjog.12202","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jog.12202","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,10,22]],"date-time":"2024-10-22T12:47:30Z","timestamp":1729601250000},"score":1,"resource":{"primary":{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/10.1111\/jog.12202"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,10,22]]},"references-count":24,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2014,2]]}},"alternative-id":["10.1111\/jog.12202"],"URL":"https:\/\/doi.org\/10.1111\/jog.12202","archive":["Portico"],"relation":{},"ISSN":["1341-8076","1447-0756"],"issn-type":[{"value":"1341-8076","type":"print"},{"value":"1447-0756","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,10,22]]}}}