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The placenta is a fetal organ that is normally discarded following delivery. Therefore, it is readily available as a source of cells without the ethical concerns normally associated with embryonic stem cells. These cells also carry less risk for age\u2010 and environmental\u2010related <jats:styled-content style=\"fixed-case\">DNA<\/jats:styled-content> damage. In addition to these practical advantages of placenta\u2010derived cells, amniotic epithelial cells possess unique stem cell\u2010like biological characteristics. In contrast to other parts of the placenta, cells from the amniotic epithelium are derived from pluripotent epiblasts and possess the ability to differentiate into all three germ layers. From a translational perspective, amnion\u2010derived stem cells are very attractive candidates for clinical application. These cells are genetically stable and do not demonstrate tumorigenicity upon transplantation, and may be endowed with immunomodulatory and\/or anti\u2010inflammatory properties. These unique characteristics have made amniotic epithelial cells attractive for use as stem cell\u2010based therapies for liver disease. Human and rodent amniotic epithelial cells have already demonstrated their therapeutic efficacy in multiple animal models. Although the detailed mechanism by which the transplanted cells generate a therapeutic effect is not yet totally understood, these dramatic results have generated significant interest for consideration of these amnion\u2010derived stem cells for clinical applications. This review covers recent findings of the therapeutic potential of amnion\u2010derived stem cells for liver diseases, and provides perspectives for future developments.<\/jats:p>","DOI":"10.1111\/jog.12213","type":"journal-article","created":{"date-parts":[[2013,11,19]],"date-time":"2013-11-19T04:55:46Z","timestamp":1384836946000},"page":"360-368","source":"Crossref","is-referenced-by-count":15,"title":["Therapeutic potential of placenta\u2010derived stem cells for liver diseases: Current status and perspectives"],"prefix":"10.1111","volume":"40","author":[{"given":"Toshio","family":"Miki","sequence":"first","affiliation":[{"name":"Department of Biochemistry and Molecular Biology Keck School of Medicine University of Southern California  Los Angeles California USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Brendan","family":"Grubbs","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Keck School of Medicine University of 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