{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T18:42:45Z","timestamp":1790016165868,"version":"4.0.1"},"reference-count":53,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2013,12,10]],"date-time":"2013-12-10T00:00:00Z","timestamp":1386633600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001700","name":"Ministry of Education, Culture, Sports, Science and Technology of Japan","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100001700","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Obstet and Gynaecol"],"published-print":{"date-parts":[[2014,3]]},"abstract":"Abstract<\/jats:title>Aim<\/jats:title>Endometriosis is a chronic inflammatory disease. Sirtuin 1 (SIRT1<\/jats:styled-content>) plays a role in regulation of inflammation. The role of SIRT1<\/jats:styled-content> in endometriosis remains unknown. We here addressed the anti\u2010inflammatory effects of SIRT1<\/jats:styled-content> on endometriosis.<\/jats:p><\/jats:sec>Methods<\/jats:title>The expression of SIRT1<\/jats:styled-content> in human ovarian endometriomas and eutopic endometria were examined using immunohistochemistry and reverse transcription polymerase chain reaction (RT\u2013PCR<\/jats:styled-content>). Endometriotic stromal cells (ESC<\/jats:styled-content>) obtained from endometriomas were exposed to either resveratrol or sirtinol, an activator or inhibitor of sirtuins, respectively, and tumor necrosis factor (TNF<\/jats:styled-content>)\u2010\u03b1\u2010induced interleukin (IL<\/jats:styled-content>)\u20108 release from the ESC<\/jats:styled-content> was assessed at mRNA<\/jats:styled-content> and protein levels.<\/jats:p><\/jats:sec>Results<\/jats:title>Both immunochemistry and RT\u2013PCR<\/jats:styled-content> demonstrated that SIRT1<\/jats:styled-content> was expressed in ESC<\/jats:styled-content> and normal endometrial stromal cells. Resveratrol suppressed TNF<\/jats:styled-content>\u2010\u03b1\u2010induced IL<\/jats:styled-content>\u20108 release from the ESC<\/jats:styled-content> in a dose\u2010dependent manner while sirtinol increased IL<\/jats:styled-content>\u20108 release.<\/jats:p><\/jats:sec>Conclusion<\/jats:title>These opposing effects of SIRT1<\/jats:styled-content>\u2010related agents suggest that IL<\/jats:styled-content>\u20108 release from the ESC<\/jats:styled-content> is modulated through the SIRT1<\/jats:styled-content> pathway. Resveratrol may have the potential to ameliorate local inflammation in endometriomas.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jog.12252","type":"journal-article","created":{"date-parts":[[2013,12,10]],"date-time":"2013-12-10T08:36:55Z","timestamp":1386664615000},"page":"770-778","source":"Crossref","is-referenced-by-count":72,"title":["Resveratrol suppresses inflammatory responses in endometrial stromal cells derived from endometriosis: A possible role of the sirtuin 1 pathway"],"prefix":"10.1111","volume":"40","author":[{"given":"Ayumi","family":"Taguchi","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology Faculty of Medicine The University of Tokyo Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Osamu","family":"Wada\u2010Hiraike","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Faculty of Medicine The University of Tokyo Tokyo 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