{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,18]],"date-time":"2026-01-18T16:46:03Z","timestamp":1768754763165,"version":"3.49.0"},"reference-count":25,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2013,12,10]],"date-time":"2013-12-10T00:00:00Z","timestamp":1386633600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Youth Fund projects of Jiangsu Province Health Department","award":["Q201305"],"award-info":[{"award-number":["Q201305"]}]},{"name":"Science and Technology Project Nanjing Municipal","award":["201201054"],"award-info":[{"award-number":["201201054"]}]},{"name":"National Natural Science Pre-research Project funds of the Southeast University","award":["3290001102"],"award-info":[{"award-number":["3290001102"]}]},{"name":"SRTP Project of the Southeast University","award":["T11431001"],"award-info":[{"award-number":["T11431001"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Obstet and Gynaecol"],"published-print":{"date-parts":[[2014,4]]},"abstract":"Abstract<\/jats:title>Aim<\/jats:title>To explore the relationship between estrogen metabolism enzyme gene polymorphism and susceptibility to uterine fibroids, and to seek the screening molecular markers for genetic traits in uterine fibroid populations.<\/jats:p><\/jats:sec>Methods<\/jats:title>A total of 300 female H<\/jats:styled-content>an C<\/jats:styled-content>hinese patients and 300 healthy female H<\/jats:styled-content>an C<\/jats:styled-content>hinese volunteers in N<\/jats:styled-content>anjing (age range, 30\u201350 years) were recruited from Z<\/jats:styled-content>hongda H<\/jats:styled-content>ospital, S<\/jats:styled-content>outheast U<\/jats:styled-content>niversity from F<\/jats:styled-content>ebruary 2011 to M<\/jats:styled-content>arch 2012. The single nucleotide polymorphisms (SNP<\/jats:styled-content>) of estrogen\u2010metabolizing enzyme genes from the two groups of women were examined by polymerase chain reaction denaturing high\u2010performance liquid chromatography, which were four COMT<\/jats:styled-content><\/jats:italic> gene loci including rs3087869, rs165774, rs165599 and rs4680, three CYP1A1<\/jats:styled-content><\/jats:italic> gene loci including rs1048943, rs4646421 and rs4646422, and three CYP1B1<\/jats:styled-content><\/jats:italic> gene loci including rs1056827, rs1056836 and rs1056837. Genotype frequencies among cases and controls were calculated and analyzed by binary logistic regression.<\/jats:p><\/jats:sec>Results<\/jats:title>Regression analysis of SNP<\/jats:styled-content> showed that COMT<\/jats:styled-content><\/jats:italic>\u2005IVS<\/jats:styled-content>1+2329C>T<\/jats:styled-content> (odds ratio [OR<\/jats:styled-content>], 2.872; 95% CI<\/jats:styled-content>, 1.690\u20134.882) and V<\/jats:styled-content>al158M<\/jats:styled-content>et (OR<\/jats:styled-content>, 2.593; 95% CI<\/jats:styled-content>, 1.546\u20134.350), CYP1A1<\/jats:styled-content><\/jats:italic>\u2005I<\/jats:styled-content>le462V<\/jats:styled-content>al (OR<\/jats:styled-content>, 2.383; 95% CI<\/jats:styled-content>, 1.418\u20134.005) and G<\/jats:styled-content>ly45A<\/jats:styled-content>sp (OR<\/jats:styled-content>, 2.489; 95% CI<\/jats:styled-content>, 1.49\u20134.159), and CYP1B1<\/jats:styled-content><\/jats:italic>\u2005A<\/jats:styled-content>la119S<\/jats:styled-content>er (OR<\/jats:styled-content>, 3.361; 95% CI<\/jats:styled-content>, 2.035\u20135.552) and L<\/jats:styled-content>eu432V<\/jats:styled-content>al (OR<\/jats:styled-content>, 0.164; 95% CI<\/jats:styled-content>, 0.061\u20130.441) influenced uterine fibroids significantly (P<\/jats:styled-content><\/jats:italic>\u2009<\u20090.05). Allele and genotype frequencies among cases and control were calculated and examined to match the Hardy\u2013Weinberg equilibrium with the \u03c72<\/jats:sup>\u2010test.<\/jats:p><\/jats:sec>Conclusion<\/jats:title>The genetic polymorphisms of IVS1<\/jats:styled-content>+2329C>T<\/jats:styled-content> and V<\/jats:styled-content>al158M<\/jats:styled-content>et loci in COMT<\/jats:styled-content><\/jats:italic>, I<\/jats:styled-content>le462V<\/jats:styled-content>al and G<\/jats:styled-content>ly45A<\/jats:styled-content>sp loci in CYP1A1<\/jats:styled-content><\/jats:italic> and A<\/jats:styled-content>la119S<\/jats:styled-content>er loci in CYP1B1<\/jats:styled-content><\/jats:italic> were risk factors for uterine leiomyoma development, and L<\/jats:styled-content>eu432V<\/jats:styled-content>al locus in CYB1B1<\/jats:styled-content><\/jats:italic> may be a protective factor. The results provide a theoretical basis for genetic screening and early intervention for uterine leiomyoma\u2010susceptible populations.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jog.12275","type":"journal-article","created":{"date-parts":[[2013,12,10]],"date-time":"2013-12-10T03:38:42Z","timestamp":1386646722000},"page":"1077-1084","source":"Crossref","is-referenced-by-count":7,"title":["Role of single nucleotide polymorphisms in estrogen\u2010metabolizing enzymes and susceptibility to uterine leiomyoma in H<\/scp>an C<\/scp>hinese: A case\u2013control study"],"prefix":"10.1111","volume":"40","author":[{"given":"Yang","family":"Shen","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology Zhongda Hospital School of Medicine Southeast University Nanjing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qian","family":"Xu","sequence":"additional","affiliation":[{"name":"Ministry of Education Key Laboratory of Environmental Medicine Engineering Southeast University Nanjing China"},{"name":"School of Public Health Southeast University Nanjing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mulan","family":"Ren","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Zhongda Hospital School of Medicine Southeast University Nanjing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yunlang","family":"Cai","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Zhongda Hospital School of Medicine Southeast University Nanjing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jie","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Zhongda Hospital School of Medicine Southeast University Nanjing 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