{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T06:11:57Z","timestamp":1790230317254,"version":"4.1.0"},"reference-count":28,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2013,12,10]],"date-time":"2013-12-10T00:00:00Z","timestamp":1386633600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Obstet and Gynaecol"],"published-print":{"date-parts":[[2014,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>The purpose of this study was to evaluate the efficacy of diffusion\u2010weighted (<jats:styled-content style=\"fixed-case\">DW<\/jats:styled-content>) magnetic resonance (<jats:styled-content style=\"fixed-case\">MR<\/jats:styled-content>) imaging to predict the tumor response to chemoradiotherapy (<jats:styled-content style=\"fixed-case\">CRT<\/jats:styled-content>) of uterine cervical cancer.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Twenty\u2010five consecutive patients with pathologically confirmed uterine cervical cancer underwent 1.5\u2010<jats:styled-content style=\"fixed-case\">T MR<\/jats:styled-content> imaging including <jats:styled-content style=\"fixed-case\">DW<\/jats:styled-content> imaging before and during <jats:styled-content style=\"fixed-case\">CRT<\/jats:styled-content>. <jats:styled-content style=\"fixed-case\">MR<\/jats:styled-content> images were reviewed for the size and apparent diffusion coefficient (<jats:styled-content style=\"fixed-case\">ADC<\/jats:styled-content>). Pathological evaluation of the therapeutic effect was performed 3 months after finishing <jats:styled-content style=\"fixed-case\">CRT<\/jats:styled-content>, and we divided the subjects into two groups: complete remission (<jats:styled-content style=\"fixed-case\">CR<\/jats:styled-content>) (<jats:italic>n<\/jats:italic>\u2009=\u200916) and residual tumor (<jats:italic>n<\/jats:italic>\u2009=\u20099).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p><jats:styled-content style=\"fixed-case\">ADC<\/jats:styled-content> was lower before <jats:styled-content style=\"fixed-case\">CRT<\/jats:styled-content> than during <jats:styled-content style=\"fixed-case\">CRT<\/jats:styled-content> (0.89\u2009\u00b1\u20090.12 and 1.25\u2009\u00b1\u20090.22\u2009\u00d7\u200910<jats:sup>\u22123<\/jats:sup>\u2009mm<jats:sup>2<\/jats:sup>\/s, respectively) (<jats:italic><jats:styled-content style=\"fixed-case\">P<\/jats:styled-content><\/jats:italic>\u2009&lt;\u20090.01). <jats:styled-content style=\"fixed-case\">ADC<\/jats:styled-content> change between before and during <jats:styled-content style=\"fixed-case\">CRT<\/jats:styled-content> (\u0394<jats:styled-content style=\"fixed-case\">ADC<\/jats:styled-content>) showed a moderate positive correlation (<jats:italic>r<\/jats:italic>\u2009=\u20090.435, <jats:italic><jats:styled-content style=\"fixed-case\">P<\/jats:styled-content><\/jats:italic>\u2009&lt;\u20090.05) with the tumor regression rates. \u0394<jats:styled-content style=\"fixed-case\">ADC<\/jats:styled-content> was higher in the <jats:styled-content style=\"fixed-case\">CR<\/jats:styled-content> group than in the residual tumor group (0.43\u2009\u00b1\u20090.23 and 0.25\u2009\u00b1\u20090.15\u2009\u00d7\u200910<jats:sup>\u22123<\/jats:sup>\u2009mm<jats:sup>2<\/jats:sup>\/s, respectively) (<jats:italic><jats:styled-content style=\"fixed-case\">P<\/jats:styled-content><\/jats:italic>\u2009&lt;\u20090.05). The <jats:styled-content style=\"fixed-case\">CR<\/jats:styled-content> rates were higher in the high \u0394<jats:styled-content style=\"fixed-case\">ADC<\/jats:styled-content> group (\u0394<jats:styled-content style=\"fixed-case\">ADC<\/jats:styled-content>\u2009\u2265\u20090.50) than in the low \u0394<jats:styled-content style=\"fixed-case\">ADC<\/jats:styled-content> group (\u0394<jats:styled-content style=\"fixed-case\">ADC<\/jats:styled-content>\u2009&lt;\u20090.49) (100% and 53%, respectively) but marginally significant (<jats:italic><jats:styled-content style=\"fixed-case\">P<\/jats:styled-content><\/jats:italic>\u2009=\u20090.057). The local control rates were not statistically different between high and low \u0394<jats:styled-content style=\"fixed-case\">ADC<\/jats:styled-content> groups (83.3% and 73.7%, respectively) (<jats:italic><jats:styled-content style=\"fixed-case\">P<\/jats:styled-content><\/jats:italic>\u2009=\u20090.602).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p><jats:styled-content style=\"fixed-case\">DW<\/jats:styled-content> imaging including <jats:styled-content style=\"fixed-case\">ADC<\/jats:styled-content> measurement may be useful for prediction and early assessment of pathological response to <jats:styled-content style=\"fixed-case\">CRT<\/jats:styled-content> for uterine cervical cancer, but its impact on local disease\u2010free survival was 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