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The aim of this review is to underscore problems in the differential diagnosis of <jats:styled-content style=\"fixed-case\">AFLP<\/jats:styled-content> and the syndrome of hemolysis, elevated liver enzymes and low platelet counts (<jats:styled-content style=\"fixed-case\">HELLP<\/jats:styled-content> syndrome) and to facilitate prompt diagnosis of <jats:styled-content style=\"fixed-case\">AFLP<\/jats:styled-content>. Published works dealing with liver dysfunction in pregnancy, <jats:styled-content style=\"fixed-case\">HELLP<\/jats:styled-content> syndrome and <jats:styled-content style=\"fixed-case\">AFLP<\/jats:styled-content> were reviewed. <jats:styled-content style=\"fixed-case\">AFLP<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">HELLP<\/jats:styled-content> syndrome shared common clinical, laboratory, histological and genetic features, and differential diagnosis between them was often difficult. However, <jats:styled-content style=\"fixed-case\">HELLP<\/jats:styled-content> syndrome was likely to occur in patients with hypertension, but <jats:styled-content style=\"fixed-case\">AFLP<\/jats:styled-content> occurred often in the absence of hypertension. In addition, <jats:styled-content style=\"fixed-case\">AFLP<\/jats:styled-content> was exclusively associated with pregnancy\u2010induced antithrombin deficiency (<jats:styled-content style=\"fixed-case\">PIATD<\/jats:styled-content>). Approximately 50% of patients with <jats:styled-content style=\"fixed-case\">AFLP<\/jats:styled-content> did not have thrombocytopenia at presentation. As the <jats:styled-content style=\"fixed-case\">S<\/jats:styled-content>wansea criteria for <jats:styled-content style=\"fixed-case\">AFLP<\/jats:styled-content> did not include <jats:styled-content style=\"fixed-case\">PIATD<\/jats:styled-content>, diagnosis of <jats:styled-content style=\"fixed-case\">AFLP<\/jats:styled-content> was delayed until manifestation of life\u2010threatening complications; 60% of women were admitted to intensive care and 15% to a specialist liver unit. In conclusion, incorporation of <jats:styled-content style=\"fixed-case\">AT<\/jats:styled-content> activity of less than 65% into the diagnostic criteria for <jats:styled-content style=\"fixed-case\">AFLP<\/jats:styled-content> may facilitate suspicion and prompt diagnosis of <jats:styled-content style=\"fixed-case\">AFLP<\/jats:styled-content>, decrease uncertainty regarding the diagnosis of <jats:styled-content style=\"fixed-case\">AFLP<\/jats:styled-content>, and contribute to better investigation and understanding of the process leading to the development of liver dysfunction.<\/jats:p>","DOI":"10.1111\/jog.12282","type":"journal-article","created":{"date-parts":[[2014,1,16]],"date-time":"2014-01-16T02:49:51Z","timestamp":1389840591000},"page":"641-649","source":"Crossref","is-referenced-by-count":65,"title":["Differentiation of acute fatty liver of pregnancy from syndrome of hemolysis, elevated liver enzymes and low platelet 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