{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T08:47:01Z","timestamp":1777452421076,"version":"3.51.4"},"reference-count":18,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2014,1,15]],"date-time":"2014-01-15T00:00:00Z","timestamp":1389744000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Obstet and Gynaecol"],"published-print":{"date-parts":[[2014,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>A recent report indicated that vascular endothelial growth factor (<jats:styled-content style=\"fixed-case\">VEGF)\u2010D<\/jats:styled-content>, regulating cell proliferation and\/or differentiation, may be associated with the development of placental mesenchymal dysplasia (<jats:styled-content style=\"fixed-case\">PMD<\/jats:styled-content>), a disorder characterized by cell proliferation\/differentiation. In <jats:styled-content style=\"fixed-case\">PMD<\/jats:styled-content> placenta, we examined the expression of five cell\u2010proliferation\/differentiation\u2010associated genes, namely, <jats:styled-content style=\"fixed-case\">W<\/jats:styled-content>nt3a, <jats:styled-content style=\"fixed-case\">W<\/jats:styled-content>nt5a, \u03b2\u2010catenin, <jats:styled-content style=\"fixed-case\">VEGF\u2010D<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">D<\/jats:styled-content>ickkopf\u20101 (<jats:styled-content style=\"fixed-case\">DKK<\/jats:styled-content>\u20101). In <jats:styled-content style=\"fixed-case\">PMD<\/jats:styled-content>, expressions of <jats:styled-content style=\"fixed-case\">W<\/jats:styled-content>nt3a, <jats:styled-content style=\"fixed-case\">W<\/jats:styled-content>nt5a and \u03b2\u2010catenin were decreased, whereas those of <jats:styled-content style=\"fixed-case\">VEGF\u2010D<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">DKK<\/jats:styled-content>\u20101 were increased. These abnormal expressions suggest a relationship between these genes and <jats:styled-content style=\"fixed-case\">PMD<\/jats:styled-content> pathogenesis\/pathophysiology.<\/jats:p>","DOI":"10.1111\/jog.12291","type":"journal-article","created":{"date-parts":[[2014,1,15]],"date-time":"2014-01-15T21:33:29Z","timestamp":1389821609000},"page":"1145-1149","source":"Crossref","is-referenced-by-count":9,"title":["Changes in expression of vascular endothelial growth factor <scp>D<\/scp>\u2010related genes in placental mesenchymal dysplasia"],"prefix":"10.1111","volume":"40","author":[{"given":"Hironori","family":"Takahashi","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology Jichi Medical University  Tochigi Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shigeki","family":"Matsubara","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Jichi Medical University  Tochigi Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tomoyuki","family":"Kuwata","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Jichi Medical University  Tochigi Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Miyuki","family":"Saruyama","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Jichi Medical University  Tochigi Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rie","family":"Usui","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Jichi Medical University  Tochigi Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Akihide","family":"Ohkuchi","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Jichi Medical University  Tochigi Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Toshihiro","family":"Takizawa","sequence":"additional","affiliation":[{"name":"Department of Molecular Medicine and Anatomy Nippon Medical School  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mitsuaki","family":"Suzuki","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Jichi Medical University  Tochigi Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2014,1,15]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1741-4520.2002.tb00897.x"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1309\/RV45HRD53YQ2YFTP"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.placenta.2012.07.015"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M304255200"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1186\/1477-7827-11-17"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1177\/002215540305100602"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.96.10.5522"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.281.5382.1509"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1006\/dbio.2001.0373"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1242\/dev.128.1.25"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.2353\/ajpath.2006.050686"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2006.09.087"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature756"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.onc.1210054"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjc.6603579"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.canlet.2008.04.032"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0037624"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1210\/en.2009-0557"}],"container-title":["Journal of Obstetrics and Gynaecology Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjog.12291","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjog.12291","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jog.12291","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,9,30]],"date-time":"2025-09-30T06:26:26Z","timestamp":1759213586000},"score":1,"resource":{"primary":{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/10.1111\/jog.12291"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,1,15]]},"references-count":18,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2014,4]]}},"alternative-id":["10.1111\/jog.12291"],"URL":"https:\/\/doi.org\/10.1111\/jog.12291","archive":["Portico"],"relation":{},"ISSN":["1341-8076","1447-0756"],"issn-type":[{"value":"1341-8076","type":"print"},{"value":"1447-0756","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,1,15]]}}}