{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T15:51:44Z","timestamp":1759333904848,"version":"build-2065373602"},"reference-count":33,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2014,2,26]],"date-time":"2014-02-26T00:00:00Z","timestamp":1393372800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Japan Spina Bifida and Hydrocephalus Research Foundation"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Obstet and Gynaecol"],"published-print":{"date-parts":[[2014,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>Fetal borderline ventriculomegaly represents a frequent dilemma in perinatal management. The present study aimed to evaluate the clinical significance of fetal borderline ventriculomegaly in a low\u2010risk Japanese population and to identify the risk factors for associated anomalies.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Data of cases of fetal borderline ventriculomegaly detected at 26\u221228 weeks of gestation by routine ultrasonographic screening of low\u2010risk singleton pregnancies between 2006 and 2012 were retrospectively collected. Ventricular width, <jats:italic>in utero<\/jats:italic> progression, associated anomalies, chromosomal abnormalities, and perinatal and postnatal outcomes were assessed. The ventricular width, <jats:italic>in utero<\/jats:italic> progression and other perinatal characteristics were compared between the isolated and non\u2010isolated groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Among the total 6020 singleton low\u2010risk pregnancies, we noted that 42 had borderline ventriculomegaly. Six (14%) of these cases had other defects by subsequent detailed examination. Ventriculomegaly resolved or regressed in 35 (83%) and progressed in four (10%) cases, of which three were associated with other anomalies. The median ventricular width was 12.8\u2009mm (range, 10.0\u201314.7) in the six non\u2010isolated cases and 10.5\u2009mm (range, 10.0\u201313.3) in the 36 isolated cases; the differences were statistically significant. A ventricular width of 12\u2009mm or more and <jats:italic>in utero<\/jats:italic> progression were more frequently observed in non\u2010isolated cases than in isolated cases.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Fetal borderline ventriculomegaly frequently resolves <jats:italic>in utero<\/jats:italic>. A ventricular diameter of more than 12\u2009mm and <jats:italic>in utero<\/jats:italic> progression are risk factors for additional anomalies. After the initial diagnosis of borderline ventriculomegaly, the pregnancy should be carefully followed up to determine whether the ventricle size is resolved, remains stable or increases.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jog.12298","type":"journal-article","created":{"date-parts":[[2014,2,26]],"date-time":"2014-02-26T02:26:50Z","timestamp":1393381610000},"page":"1030-1036","source":"Crossref","is-referenced-by-count":4,"title":["Perinatal characteristics of fetuses with borderline ventriculomegaly detected by routine ultrasonographic screening of low\u2010risk populations"],"prefix":"10.1111","volume":"40","author":[{"given":"Nobuhiro","family":"Hidaka","sequence":"first","affiliation":[{"name":"Department of Maternal Fetal Medicine Osaka Medical Center and Research Institute for Maternal and Child Health  Izumi Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Keisuke","family":"Ishii","sequence":"additional","affiliation":[{"name":"Department of Maternal Fetal Medicine Osaka Medical Center and Research Institute for Maternal and Child Health  Izumi Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ryoko","family":"Kanazawa","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine Osaka Medical Center and Research Institute for Maternal and Child Health  Izumi Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Akiko","family":"Miyagi","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine Osaka Medical Center and Research Institute for Maternal and Child Health  Izumi Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Akemi","family":"Irie","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine Osaka Medical Center and Research Institute for Maternal and Child Health  Izumi Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shusaku","family":"Hayashi","sequence":"additional","affiliation":[{"name":"Department of Maternal Fetal Medicine Osaka Medical Center and Research Institute for Maternal and Child Health  Izumi Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nobuaki","family":"Mitsuda","sequence":"additional","affiliation":[{"name":"Department of Maternal Fetal Medicine Osaka Medical Center and Research Institute for Maternal and Child Health  Izumi Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2014,2,26]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.8831"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.7863\/jum.2010.29.1.157"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.7863\/jum.1991.10.3.121"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1148\/radiology.169.3.3055034"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1148\/radiology.181.1.1887016"},{"key":"e_1_2_6_7_1","first-page":"1","volume-title":"Prenatal Diagnosis of Congenital Anomalies","author":"Romero R","year":"1988"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0095-5108(05)70053-1"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1080\/14767050601036188"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-0528.2006.01050.x"},{"key":"e_1_2_6_11_1","first-page":"250","article-title":"Sonographic evaluation of the normal developmental anatomy of the fetal cerebral ventricles. 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