{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,25]],"date-time":"2025-07-25T10:39:54Z","timestamp":1753439994746},"reference-count":5,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2014,3,9]],"date-time":"2014-03-09T00:00:00Z","timestamp":1394323200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Obstet and Gynaecol"],"published-print":{"date-parts":[[2014,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Extragastrointestinal stromal tumors (<jats:styled-content style=\"fixed-case\">EGIST<\/jats:styled-content>) primarily arising from the female genital tract are extremely rare. We report a case of <jats:styled-content style=\"fixed-case\">EGIST<\/jats:styled-content> presenting as a recurrent vulvar mass with genetic analyses. A 59\u2010year\u2010old woman was found to have a 4\u2010cm recurrent mass in the right vulva after 6 months of the first resection. Histological findings showed that the uniform spindle cells formed interlacing bundles, with high cellular density and mild to moderate atypia. Mitotic activity averaged 10 mitoses per 50 high\u2010power fields. Immunohistochemical evaluation revealed that the tumor cells exhibited strong and diffuse staining for <jats:styled-content style=\"fixed-case\">CD117<\/jats:styled-content>, <jats:styled-content style=\"fixed-case\">CD34<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">DOG1<\/jats:styled-content>. <jats:styled-content style=\"fixed-case\">Ki67<\/jats:styled-content> labeling was approximately 15%. Molecular analysis showed an in\u2010frame protein deletion (<jats:styled-content style=\"fixed-case\">P551_Q556del<\/jats:styled-content>) at exon 11 of <jats:italic>c\u2010KIT<\/jats:italic>. The tumor was diagnosed as an <jats:styled-content style=\"fixed-case\">EGIST<\/jats:styled-content>. The patient was treated with imatinib, and was healthy at 12\u2010month follow\u2010up. <jats:styled-content style=\"fixed-case\">EGIST<\/jats:styled-content> should be considered in the differential diagnosis of vulvar mesenchymal tumors.<\/jats:p>","DOI":"10.1111\/jog.12316","type":"journal-article","created":{"date-parts":[[2014,3,10]],"date-time":"2014-03-10T01:32:46Z","timestamp":1394415166000},"page":"1459-1462","source":"Crossref","is-referenced-by-count":4,"title":["Extragastrointestinal stromal tumor presenting as a recurrent vulvar mass"],"prefix":"10.1111","volume":"40","author":[{"given":"Dujuan","family":"Li","sequence":"first","affiliation":[{"name":"Department of Pathology Henan Provincial People's Hospital People's Hospital of Zhengzhou University  Zhengzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuewu","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Pathology Henan Provincial People's Hospital People's Hospital of Zhengzhou University  Zhengzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hongjian","family":"Xie","sequence":"additional","affiliation":[{"name":"Department of Pathology Henan Provincial People's Hospital People's Hospital of Zhengzhou University  Zhengzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qiuyu","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Pathology Henan Provincial People's Hospital People's Hospital of Zhengzhou University  Zhengzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lingfei","family":"Kong","sequence":"additional","affiliation":[{"name":"Department of Pathology Henan Provincial People's Hospital People's Hospital of Zhengzhou University  Zhengzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2014,3,9]]},"reference":[{"key":"e_1_2_5_2_1","first-page":"797","article-title":"Extragastrointestinal stromal tumor originating from the vulva","volume":"2","author":"Fukuda T","year":"2011","journal-title":"Oncol Lett"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1080\/01443610701405689"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0b013e3181238cec"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-200404000-00007"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/modpathol.3880099"}],"container-title":["Journal of Obstetrics and Gynaecology Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjog.12316","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjog.12316","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jog.12316","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,2]],"date-time":"2023-10-02T21:34:23Z","timestamp":1696282463000},"score":1,"resource":{"primary":{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/10.1111\/jog.12316"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,3,9]]},"references-count":5,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2014,5]]}},"alternative-id":["10.1111\/jog.12316"],"URL":"https:\/\/doi.org\/10.1111\/jog.12316","archive":["Portico"],"relation":{},"ISSN":["1341-8076","1447-0756"],"issn-type":[{"value":"1341-8076","type":"print"},{"value":"1447-0756","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,3,9]]}}}