{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,27]],"date-time":"2026-06-27T13:33:23Z","timestamp":1782567203137,"version":"3.54.5"},"reference-count":39,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2014,3,9]],"date-time":"2014-03-09T00:00:00Z","timestamp":1394323200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Obstet and Gynaecol"],"published-print":{"date-parts":[[2014,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>To investigate hormonal dynamics in a group of non\u2010obese polycystic ovary syndrome (<jats:styled-content style=\"fixed-case\">PCOS<\/jats:styled-content>) patients under myo\u2010inositol (<jats:styled-content style=\"fixed-case\">MYO<\/jats:styled-content>) administration.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Hormonal profiles, insulin response to oral glucose tolerance test (<jats:styled-content style=\"fixed-case\">OGTT<\/jats:styled-content>) and luteinizing hormone (<jats:styled-content style=\"fixed-case\">LH<\/jats:styled-content>) response to gonadotropin\u2010releasing hormone (<jats:styled-content style=\"fixed-case\">GnRH<\/jats:styled-content>) stimulation test before and after the administration of a preparation of <jats:styled-content style=\"fixed-case\">MYO<\/jats:styled-content> (3\u2009g p.o. daily) mixed with lactoferrin and bromelin, in a group (<jats:italic>n<\/jats:italic>\u2009=\u200924) of normal weight <jats:styled-content style=\"fixed-case\">PCOS<\/jats:styled-content> patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>After the treatment interval, body mass index (<jats:styled-content style=\"fixed-case\">BMI<\/jats:styled-content>) did not change while <jats:styled-content style=\"fixed-case\">LH<\/jats:styled-content>, <jats:styled-content style=\"fixed-case\">LH<\/jats:styled-content>\/follicle\u2010stimulating hormone, 17\u2010hydroxy\u2010progesterone and androstenedione decreased significantly. Insulin response to <jats:styled-content style=\"fixed-case\">OGTT<\/jats:styled-content> was significantly reduced after the treatment interval (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.05) as well as <jats:styled-content style=\"fixed-case\">GnRH<\/jats:styled-content>\u2010induced <jats:styled-content style=\"fixed-case\">LH<\/jats:styled-content> response (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.05). High\u2010sensitivity C\u2010reactive protein decreased significantly after the treatment interval.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p><jats:styled-content style=\"fixed-case\">MYO<\/jats:styled-content> administration positively modulates insulin sensitivity in non\u2010obese <jats:styled-content style=\"fixed-case\">PCOS<\/jats:styled-content> patients without compensatory hyperinsulinemia, improving hormonal parameters. The presence of bromelin in the formulation modulated the pro\u2010inflammatory state that characterizes <jats:styled-content style=\"fixed-case\">PCOS<\/jats:styled-content>, independently of <jats:styled-content style=\"fixed-case\">BMI<\/jats:styled-content>.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jog.12319","type":"journal-article","created":{"date-parts":[[2014,3,10]],"date-time":"2014-03-10T01:32:56Z","timestamp":1394415176000},"page":"1353-1360","source":"Crossref","is-referenced-by-count":24,"title":["Myo\u2010inositol modulates insulin and luteinizing hormone secretion in normal weight patients with polycystic ovary syndrome"],"prefix":"10.1111","volume":"40","author":[{"given":"Alessandro D.","family":"Genazzani","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology Gynecological Endocrinology Center University of Modena and Reggio Emilia  Modena 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