{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T12:01:27Z","timestamp":1791892887466,"version":"4.3.4"},"reference-count":36,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2014,4,3]],"date-time":"2014-04-03T00:00:00Z","timestamp":1396483200000},"content-version":"vor","delay-in-days":2,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Obstet and Gynaecol"],"published-print":{"date-parts":[[2014,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>Recent studies suggest that misoprostol may be more effective than dinoprostone in pregnant women with unfavorable cervix. The objective here is to investigate and compare the efficacy and safety of intravaginal misoprostol and intracervical dinoprostone for labor induction, including incidence of cesarean section, vaginal delivery rate within 24\u2009h, uterine hyperstimulation, tachysystole, oxytocin augmentation, neonatal intensive care unit (<jats:styled-content style=\"fixed-case\">NICU<\/jats:styled-content>) admissions, and <jats:styled-content style=\"fixed-case\">A<\/jats:styled-content>pgar score of less than 7 at 1 and 5\u2009min.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Databases searched were <jats:styled-content style=\"fixed-case\">MEDLINE<\/jats:styled-content>, <jats:styled-content style=\"fixed-case\">EMBASE<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">C<\/jats:styled-content>ochrane <jats:styled-content style=\"fixed-case\">C<\/jats:styled-content>entral <jats:styled-content style=\"fixed-case\">R<\/jats:styled-content>egister of <jats:styled-content style=\"fixed-case\">C<\/jats:styled-content>ontrolled <jats:styled-content style=\"fixed-case\">T<\/jats:styled-content>rials, up to <jats:styled-content style=\"fixed-case\">J<\/jats:styled-content>uly 2013. Randomized controlled trials comparing intravaginal misoprostol with intracervical dinoprostone in women with singleton pregnancy, intact membranes and unfavorable cervix (<jats:styled-content style=\"fixed-case\">B<\/jats:styled-content>ishop's &lt;6) were included. Pooled relative risk, mean difference and 95% confidence intervals were calculated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The use of misoprostol was significantly effective in increasing the rate of vaginal delivery within 24\u2009h and less oxytocin augmentation when compared with dinoprostone. However, the incidents of uterine hyperstimulation and tachysystole were significantly higher under the misoprostol protocol than dinoprostone protocol. Furthermore, we found similar efficiency in the rate of cesarean delivery, <jats:styled-content style=\"fixed-case\">NICU<\/jats:styled-content> admission and <jats:styled-content style=\"fixed-case\">A<\/jats:styled-content>pgar score at 1 and 5\u2009min among the study groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Intravaginal misoprostol appears to be more efficient for labor induction than intracervical dinoprostone; however, dinoprostone has been demonstrated to be safer because of the lower incidence of uterine hyperstimulation and tachysystole. Further high\u2010quality studies assessing the possible effectiveness of misoprostol and dinoprostone in selected groups of patients are warranted.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jog.12333","type":"journal-article","created":{"date-parts":[[2014,4,3]],"date-time":"2014-04-03T02:41:06Z","timestamp":1396492866000},"page":"897-906","source":"Crossref","is-referenced-by-count":49,"title":["Efficacy and safety of intravaginal misoprostol versus intracervical dinoprostone for labor induction at term: A systematic review and meta\u2010analysis"],"prefix":"10.1111","volume":"40","author":[{"given":"Aihai","family":"Liu","sequence":"first","affiliation":[{"name":"Gynecology Department The Second Affiliated Hospital of Wenzhou Medical University  Wenzhou Zhejiang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jieqiang","family":"Lv","sequence":"additional","affiliation":[{"name":"Gynecology Department The Second Affiliated Hospital of Wenzhou Medical University  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