{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T01:13:15Z","timestamp":1787015595268,"version":"build-2736575974"},"reference-count":19,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2014,4,2]],"date-time":"2014-04-02T00:00:00Z","timestamp":1396396800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Ministry of Health, Labor and Welfare of Japan","award":["H18-children-general-006"],"award-info":[{"award-number":["H18-children-general-006"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Obstet and Gynaecol"],"published-print":{"date-parts":[[2014,5]]},"abstract":"Abstract<\/jats:title>\n \n Aim<\/jats:title>\n \n The aim of this study was to analyze the causes and outcomes for intracerebral hemorrhage (\n ICH<\/jats:styled-content>\n ) occurring during pregnancy and postnatally.\n <\/jats:p>\n <\/jats:sec>\n \n Material and Methods<\/jats:title>\n \n A nationwide study of pregnancy\u2010related\n ICH<\/jats:styled-content>\n in\n J<\/jats:styled-content>\n apan was performed. We contacted 1582 facilities to identify women with\n ICH<\/jats:styled-content>\n in pregnancy or postnatally between 1\n J<\/jats:styled-content>\n anuary 2006 and 31\n D<\/jats:styled-content>\n ecember 2006. A total of 1012 facilities (70%) responded with completed questionnaires. Risk factors for\n ICH<\/jats:styled-content>\n , neurological features, onset to diagnosis time (\n O<\/jats:styled-content>\n \u2013\n D<\/jats:styled-content>\n time), and obstetric data were recorded.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n Thirty\u2010eight cases of pregnancy\u2010associated\n ICH<\/jats:styled-content>\n were identified, corresponding to 3.5 per 100\u2009000 deliveries. There were seven maternal deaths, giving a case mortality rate of 18.4%. Pre\u2010eclampsia was identified in 10 cases (26.3%) and hemolysis elevated liver enzymes and low platelet count (\n HELLP<\/jats:styled-content>\n ) syndrome was present in five. There were four cases (10.5%) with\n M<\/jats:styled-content>\n oyamoya disease and seven (18.4%) with arteriovenous malformation.\n HELLP<\/jats:styled-content>\n syndrome and moderately or severely disturbed consciousness at disease onset were significantly associated with a poor outcome (modified Rankin Scale \u22653). Pre\u2010eclampsia,\n HELLP<\/jats:styled-content>\n syndrome and\n O\u2013D<\/jats:styled-content>\n time >3\u2009h were significantly associated with maternal mortality.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n \n Early diagnosis may prevent maternal death, even in severe cases of pregnancy\u2010related\n ICH<\/jats:styled-content>\n . However, maternal\u2013fetal care centers do not always have full\u2010time neurosurgeons or diagnostic imaging tools suitable for diagnosis of\n ICH<\/jats:styled-content>\n . Thus, a network should be established between maternity centers and neurosurgery departments with computed tomography or magnetic resonance imaging available at all times. We recommend transferal of pregnant women with neurological symptoms to a regional facility that is equipped to treat such patients.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/jog.12336","type":"journal-article","created":{"date-parts":[[2014,4,2]],"date-time":"2014-04-02T04:08:21Z","timestamp":1396411701000},"page":"1267-1273","source":"Crossref","is-referenced-by-count":34,"title":["Factors contributing to mortality and morbidity in pregnancy\u2010associated intracerebral hemorrhage in\n J<\/scp>\n apan"],"prefix":"10.1111","volume":"40","author":[{"given":"Jun","family":"Yoshimatsu","sequence":"first","affiliation":[{"name":"Department of Perinatology and Gynecology National Cerebral and Cardiovascular Center Osaka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomoaki","family":"Ikeda","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Mie University Osaka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shinji","family":"Katsuragi","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Sakakibara Heart Institute Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazuo","family":"Minematsu","sequence":"additional","affiliation":[{"name":"Department of Cerebrovascular Medicine National Cerebral and Cardiovascular Center Suita Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazunori","family":"Toyoda","sequence":"additional","affiliation":[{"name":"Department of Cerebrovascular Medicine National Cerebral and Cardiovascular Center Suita Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazuyuki","family":"Nagatsuka","sequence":"additional","affiliation":[{"name":"Department of Neurology National Cerebral and Cardiovascular Center Suita Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroaki","family":"Naritomi","sequence":"additional","affiliation":[{"name":"Department of Neurology National Cerebral and Cardiovascular Center Suita Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susumu","family":"Miyamoto","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery National Cerebral and Cardiovascular Center Suita Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Koji","family":"Iihara","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery National Cerebral and Cardiovascular Center Suita Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haruko","family":"Yamamoto","sequence":"additional","affiliation":[{"name":"Advanced Medical Technology Development National Cerebral and Cardiovascular Center Suita 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