{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,19]],"date-time":"2025-05-19T13:28:36Z","timestamp":1747661316993},"reference-count":32,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2014,4,21]],"date-time":"2014-04-21T00:00:00Z","timestamp":1398038400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Obstet and Gynaecol"],"published-print":{"date-parts":[[2014,5]]},"abstract":"Abstract<\/jats:title>Aim<\/jats:title>To study thyroid function profile, atherogenic markers and their association in young women with PCOS<\/jats:styled-content>.<\/jats:p><\/jats:sec>Methods<\/jats:title>Thirty women aged 15\u201330 years with PCOS<\/jats:styled-content> (married and unmarried) and an equal number of age\u2010matched controls were included in this study. The following parameters were assessed: thyroid\u2010stimulating hormone (TSH<\/jats:styled-content>), free triiodothyronine (FT<\/jats:styled-content>3), tetraiodothyronine (FT<\/jats:styled-content>4), total cholesterol (TC<\/jats:styled-content>), triglycerides (TG<\/jats:styled-content>), high\u2010density lipoprotein cholesterol (HDL<\/jats:styled-content>\u2010C<\/jats:styled-content>), low\u2010density lipoprotein cholesterol (LDL<\/jats:styled-content>\u2010C<\/jats:styled-content>), very low\u2010density lipoprotein cholesterol (VLDL<\/jats:styled-content>\u2010C<\/jats:styled-content>) homocysteine (HCY<\/jats:styled-content>), lipoprotein(a) (Lp<\/jats:styled-content>[a]) levels.<\/jats:p><\/jats:sec>Results<\/jats:title>Thyroid function tests were within normal ranges in all the cases and controls. The following parameters were significantly elevated in women with PCOS<\/jats:styled-content> compared to controls: serum TC<\/jats:styled-content>, TG<\/jats:styled-content>, LDL<\/jats:styled-content>,VLDL<\/jats:styled-content>, HCY<\/jats:styled-content> and Lp<\/jats:styled-content>(a). Married women with PCOS<\/jats:styled-content> had significantly higher levels of TC<\/jats:styled-content>, TG<\/jats:styled-content>, VLDL<\/jats:styled-content>\u2010C<\/jats:styled-content>, LDL<\/jats:styled-content>\u2010C<\/jats:styled-content>, HCY<\/jats:styled-content> and Lp<\/jats:styled-content>(a). Among unmarried PCOS<\/jats:styled-content> cases, HCY<\/jats:styled-content> levels were found to be significantly higher compared to unmarried controls. In group 1, Lp<\/jats:styled-content>(a) levels were found to be high. In group 2, TC<\/jats:styled-content>, TG<\/jats:styled-content>, LDL<\/jats:styled-content>\u2010C<\/jats:styled-content>, VLDL<\/jats:styled-content>\u2010C<\/jats:styled-content>, Lp<\/jats:styled-content>(a) and HCY<\/jats:styled-content> levels were found to be high. In group 3, TC<\/jats:styled-content>, VLDL<\/jats:styled-content>\u2010C<\/jats:styled-content> and Lp<\/jats:styled-content>(a) were found to be high.<\/jats:p><\/jats:sec>Conclusion<\/jats:title>Alteration in lipid metabolism and elevated HCY<\/jats:styled-content> and Lp<\/jats:styled-content>(a) levels were present in women with PCOS<\/jats:styled-content>, which were independent of their thyroid status. Unmarried PCOS<\/jats:styled-content> women are predisposed to develop cardiovascular diseases rather than married PCOS<\/jats:styled-content> women. Group 2 PCOS<\/jats:styled-content> women are predisposed to get cardiovascular diseases rather than group 1 and group 3. PCOS<\/jats:styled-content> women need not have hypothyroidism.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jog.12346","type":"journal-article","created":{"date-parts":[[2014,4,21]],"date-time":"2014-04-21T07:42:55Z","timestamp":1398066175000},"page":"1361-1367","source":"Crossref","is-referenced-by-count":6,"title":["Cardiovascular risk markers and thyroid status in young I<\/scp>ndian women with polycystic ovarian syndrome: A case\u2013control study"],"prefix":"10.1111","volume":"40","author":[{"given":"Perla","family":"Sravan Kumar","sequence":"first","affiliation":[{"name":"Department of Biochemistry JIPMER Puducherry India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Palghat Hariharan","family":"Ananthanarayanan","sequence":"additional","affiliation":[{"name":"Department of Biochemistry JIPMER Puducherry India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Soundravally","family":"Rajendiran","sequence":"additional","affiliation":[{"name":"Department of Biochemistry JIPMER Puducherry India"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2014,4,21]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199509283331307"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199806253382603"},{"key":"e_1_2_7_4_1","doi-asserted-by":"crossref","first-page":"1917","DOI":"10.1001\/jama.1988.03410130125037","article-title":"Low\u2010density lipoprotein subclass patterns and risk of myocardial infarction","volume":"260","author":"Austin MA","year":"1998","journal-title":"JAMA"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.12.4.1789"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2265.1992.tb02295.x"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.atherosclerosis.2005.10.007"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1210\/edrv.20.5.0381"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199804093381507"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.3109\/01443611003763408"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199104253241701"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa011364"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-2007-1016308"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1742-1241.2008.01897.x"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/dep121"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2010.12.027"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2008.09.070"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1210\/er.18.6.774"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.83.9.3078"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199901143400207"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/12.5.905"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1097\/00006254-200005000-00026"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000053731.05365.5A"},{"key":"e_1_2_7_24_1","first-page":"11","article-title":"Polycystic ovary syndrome: An intriguing diagnosis","volume":"7","author":"Troischt MJ","year":"2008","journal-title":"Consultant for Pediatricians"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.ATV.9.1.96"},{"key":"e_1_2_7_26_1","first-page":"63","volume-title":"Structure and Function of Plasma Apolipoproteins","author":"Yang CY","year":"1992"},{"key":"e_1_2_7_27_1","first-page":"377","volume-title":"Polycystic Ovary Syndrome","author":"Zawadzki JK","year":"1992"},{"key":"e_1_2_7_28_1","first-page":"342","volume-title":"Polycystic Ovary Syndrome","author":"Zawadzki JK","year":"1992"},{"key":"e_1_2_7_29_1","first-page":"363","article-title":"Treatment of hyperandrogenism and hyperinsulinemia in PCOS patients with essential amino acids. 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