{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T05:47:03Z","timestamp":1789451223964,"version":"build-2803163510"},"reference-count":30,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2014,4,21]],"date-time":"2014-04-21T00:00:00Z","timestamp":1398038400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Obstet and Gynaecol"],"published-print":{"date-parts":[[2014,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>The aim of this study was to evaluate the effect of local injection of vasopressin on blood loss and secondary impact on complications during cesarean section in patients with placenta previa.<\/jats:p><\/jats:sec><jats:sec><jats:title>Material and Methods<\/jats:title><jats:p>We retrospectively reviewed the medical records of all patients diagnosed with placenta previa admitted to our hospital. Two consecutive periods were compared. During period <jats:styled-content style=\"fixed-case\">B<\/jats:styled-content>, 59 patients underwent the local injection of a vasopressin solution (4\u2009U in 20\u2009mL of saline) into the placental implantation site after placental delivery. During period <jats:styled-content style=\"fixed-case\">A<\/jats:styled-content>, 50 patients underwent cesarean section without vasopressin injection, and were analyzed as a control group. The estimated blood loss was recorded, as were the complications during surgery. In addition, the expression of the vasopressin <jats:styled-content style=\"fixed-case\">V<\/jats:styled-content>1\u03b1 receptor in uterine smooth muscle was evaluated by immunohistochemistry.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The mean estimated blood loss was significantly lower in the vasopressin group than in the control group. There were no statistically significant differences with surgical complications. The vasopressin <jats:styled-content style=\"fixed-case\">V<\/jats:styled-content>1\u03b1 receptor was highly expressed in smooth muscle cells in the lower segment of the uterine body, whereas the immunoreactivity for the oxytocin receptor was faint in the lower segment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The local injection of vasopressin into the placental implantation site significantly reduced the blood loss without increasing the morbidity.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jog.12356","type":"journal-article","created":{"date-parts":[[2014,4,21]],"date-time":"2014-04-21T07:44:37Z","timestamp":1398066277000},"page":"1249-1256","source":"Crossref","is-referenced-by-count":16,"title":["Local injection of vasopressin reduces the blood loss during cesarean section in placenta previa"],"prefix":"10.1111","volume":"40","author":[{"given":"Sosuke","family":"Kato","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology 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