{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,16]],"date-time":"2026-07-16T18:39:05Z","timestamp":1784227145737,"version":"3.55.0"},"reference-count":27,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2014,6,2]],"date-time":"2014-06-02T00:00:00Z","timestamp":1401667200000},"content-version":"vor","delay-in-days":1,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Obstet and Gynaecol"],"published-print":{"date-parts":[[2014,6]]},"abstract":"Abstract<\/jats:title>Aim<\/jats:title>We investigated thyroid function and the impact of gestational transient thyrotoxicosis (GTT<\/jats:styled-content>) on pregnancy outcome in patients with hyperemesis gravidarum (HG<\/jats:styled-content>; n<\/jats:italic>\u2009=\u2009143) who were hospitalized for rehydration.<\/jats:p><\/jats:sec>Methods<\/jats:title>Serum thyroid\u2010stimulating hormone (TSH<\/jats:styled-content>), free T<\/jats:styled-content>3 (FT<\/jats:styled-content>3), free T<\/jats:styled-content>4 (FT<\/jats:styled-content>4), thyroid globulin antibody (TgAb<\/jats:styled-content>), thyroid peroxidase antibody (TPOAb<\/jats:styled-content>) and hCG<\/jats:styled-content> were measured after admission.<\/jats:p><\/jats:sec>Results<\/jats:title>The total prevalence of thyrotoxicosis in HG<\/jats:styled-content> was 48.3%; GTT<\/jats:styled-content> was the main form (45.5%). The total incidence of GTT<\/jats:styled-content> increased significantly if serum hCG<\/jats:styled-content> was more than 80\u2009000\u2009IU\/L, subclinical GTT<\/jats:styled-content> if serum hCG<\/jats:styled-content> was 80\u2009000\u2013140\u2009000\u2009IU\/L and clinical GTT<\/jats:styled-content> if serum hCG<\/jats:styled-content> was more than 180\u2009000\u2009IU\/L. GTT<\/jats:styled-content> did not require antithyroid therapy. The course of TSH<\/jats:styled-content>, FT<\/jats:styled-content>3 and FT<\/jats:styled-content>4 were followed in 34 cases of GTT<\/jats:styled-content>; thyroid function normalized by the second trimester. Of 65 patients with GTT<\/jats:styled-content>, two underwent abortions due to unplanned pregnancies, two delivered prematurely and two infants had macrosomia. There were no other complications. All newborns (n<\/jats:italic>\u2009=\u200963) of mothers with GTT<\/jats:styled-content> had normal TSH<\/jats:styled-content> levels.<\/jats:p><\/jats:sec>Conclusion<\/jats:title>GTT<\/jats:styled-content> is common in HG<\/jats:styled-content>. The severity of GTT<\/jats:styled-content> is related to serum hCG<\/jats:styled-content> levels. In patients with HG<\/jats:styled-content> and GTT<\/jats:styled-content>, thyroid function normalized by the second trimester without antithyroid treatment. GTT<\/jats:styled-content> did not affect pregnancy outcomes.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jog.12372","type":"journal-article","created":{"date-parts":[[2014,6,3]],"date-time":"2014-06-03T03:14:07Z","timestamp":1401765247000},"page":"1567-1572","source":"Crossref","is-referenced-by-count":34,"title":["Clinical analysis of 65 cases of hyperemesis gravidarum with gestational transient thyrotoxicosis"],"prefix":"10.1111","volume":"40","author":[{"given":"Shuiya","family":"Sun","sequence":"first","affiliation":[{"name":"Department of Endocrinology Sir Run Run Shaw Hospital Zhejiang University School of Medicine Hangzhou Zhejiang China"},{"name":"Jiaxing Maternity and Child Health Care Hospital Jiaxing Zhejiang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xia","family":"Qiu","sequence":"additional","affiliation":[{"name":"Department of Endocrinology Sir Run Run Shaw Hospital Zhejiang University School of Medicine Hangzhou Zhejiang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiaqiang","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Endocrinology Sir Run Run Shaw Hospital Zhejiang University School of Medicine Hangzhou Zhejiang China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,6,2]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMcp1003896"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/00003081-199809000-00014"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/0301-2115(95)02238-4"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2265.2001.01353.x"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0889-8529(05)70303-0"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1210\/er.2009-0041"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.AOG.0000278571.93861.26"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.4061\/2011\/142413"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1097\/00003081-199703000-00006"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1089\/thy.1995.5.425"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1210\/jcem-73-4-824"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.75.5.1333"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.80.2.473"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1089\/thy.1999.9.653"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2007-0141"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.beem.2004.03.010"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1089\/thy.2009.0079"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1210\/jcem-48-5-793"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-0528.2002.01223.x"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1089\/thy.2011.0087"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1096-6374(03)00055-8"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.AOG.0000197991.64246.9a"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.3109\/09513590.2012.692001"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9378(89)90088-4"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9378(03)00944-X"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2265.2001.01224.x"},{"key":"e_1_2_6_28_1","first-page":"87","volume-title":"Obstetrics and Gynecology","author":"Jie L","year":"2008"}],"container-title":["Journal of Obstetrics and Gynaecology Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjog.12372","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjog.12372","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jog.12372","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,2]],"date-time":"2023-10-02T09:30:16Z","timestamp":1696239016000},"score":1,"resource":{"primary":{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/10.1111\/jog.12372"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,6]]},"references-count":27,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2014,6]]}},"alternative-id":["10.1111\/jog.12372"],"URL":"https:\/\/doi.org\/10.1111\/jog.12372","archive":["Portico"],"relation":{},"ISSN":["1341-8076","1447-0756"],"issn-type":[{"value":"1341-8076","type":"print"},{"value":"1447-0756","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,6]]}}}