{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T00:20:44Z","timestamp":1787617244761,"version":"build-2736575974"},"reference-count":29,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2014,6,2]],"date-time":"2014-06-02T00:00:00Z","timestamp":1401667200000},"content-version":"vor","delay-in-days":1,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Programs of Science and Technology Commission Foundation","award":["No.D09050703570902"],"award-info":[{"award-number":["No.D09050703570902"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Obstet and Gynaecol"],"published-print":{"date-parts":[[2014,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>The aim of this study was to evaluate the therapeutic effect of laser vaporization for vaginal intraepithelial neoplasia (<jats:styled-content style=\"fixed-case\">VAIN<\/jats:styled-content>) after hysterectomy in <jats:styled-content style=\"fixed-case\">C<\/jats:styled-content>hinese women and to identify factors affecting persistence\/recurrence.<\/jats:p><\/jats:sec><jats:sec><jats:title>Material and Methods<\/jats:title><jats:p>Twenty\u2010eight <jats:styled-content style=\"fixed-case\">VAIN<\/jats:styled-content> patients after hysterectomy due to cervical intraepithelial neoplasia (group 1) and 11 <jats:styled-content style=\"fixed-case\">VAIN<\/jats:styled-content> patients due to cervical cancer (group 2) were reviewed retrospectively. All patients were treated with at least one episode of laser vaporization between 2010 and 2011, and then followed up every 3 months for at least 1 year. Cox regression analysis was used to identify independent factors predicting persistence\/recurrence.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>All <jats:styled-content style=\"fixed-case\">VAIN<\/jats:styled-content> patients achieved remission after two episodes of laser treatment, with 85.7% complete regression in group 1 and 54.5% in group 2. The first episode of the treatment had a significantly higher success rate in group 1 than in group 2 (46.2% vs 0.0%). All patients had no recurrence during a mean follow\u2010up time of 22.8\u201327.8 months (range 12\u201339 months). However, infection persisted in 21 (61.8%) of 34 human\u2010papillomavirus\u2010positive patients after laser vaporization. Severity of <jats:styled-content style=\"fixed-case\">VAIN<\/jats:styled-content> was the only significant independent predictor of persistence\/recurrence after one episode of the treatment (adjusted odds ratio, 4.08; 95% confidence interval, 1.28\u201312.96; <jats:italic>P<\/jats:italic>\u2009=\u20090.017). Laser treatments were well tolerated with no major side\u2010effects.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Laser vaporization may be a useful option for the treatment of <jats:styled-content style=\"fixed-case\">VAIN<\/jats:styled-content> after hysterectomy. However, a follow\u2010up is required to assess the long\u2010term efficacy of laser treatment.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jog.12383","type":"journal-article","created":{"date-parts":[[2014,6,3]],"date-time":"2014-06-03T03:14:07Z","timestamp":1401765247000},"page":"1740-1747","source":"Crossref","is-referenced-by-count":24,"title":["Therapeutic effect of laser vaporization for vaginal intraepithelial neoplasia following hysterectomy due to premalignant and malignant lesions"],"prefix":"10.1111","volume":"40","author":[{"given":"Yan","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Gynecological Oncology Beijing Obstetrics and Gynecology Hospital of Capital Medical University  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei\u2010Min","family":"Kong","sequence":"additional","affiliation":[{"name":"Department of Gynecological Oncology Beijing Obstetrics and Gynecology Hospital of Capital Medical University  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu\u2010Mei","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Gynecological Oncology Beijing Obstetrics and Gynecology Hospital of Capital Medical University  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian\u2010Dong","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Gynecological Oncology Beijing Obstetrics and Gynecology Hospital of Capital Medical University  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei\u2010Yuan","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Gynecological Oncology Beijing Obstetrics and Gynecology Hospital of Capital Medical University  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,6,2]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-0528.2006.01099.x"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-0528.1992.tb13758.x"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9378(77)90091-6"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9378(97)80018-X"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1525-1438.2000.010005382.x"},{"key":"e_1_2_7_7_1","first-page":"1219","article-title":"Risk factors for the development of vaginal intraepithelial neoplasia","volume":"125","author":"Li H","year":"2012","journal-title":"Chin Med J (Engl)"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-0528.1988.tb06499.x"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0301-2115(02)00209-9"},{"key":"e_1_2_7_10_1","first-page":"334","article-title":"Carcinoma in situ of the vagina. 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