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So, we carried out an experiment to explore whether vitamin <jats:styled-content style=\"fixed-case\">C<\/jats:styled-content> (<jats:styled-content style=\"fixed-case\">VitC<\/jats:styled-content>) can be supplied for placental protection under <jats:styled-content style=\"fixed-case\">FHD<\/jats:styled-content> and its impacts on <jats:styled-content style=\"fixed-case\">P<\/jats:styled-content>\u2010glycoprotein expression.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Fetal heart dysfunction was induced by two intra\u2010amniotic injections of isoproterenol, then (<jats:styled-content style=\"fixed-case\">VitC<\/jats:styled-content>) was supplied. Hematoxylin\u2013eosin (<jats:styled-content style=\"fixed-case\">HE<\/jats:styled-content>) staining was used to evaluate placental histology, and oxidative stress was measured by total antioxidant capacity, total superoxide dismutase and level of advanced oxidation protein products (<jats:styled-content style=\"fixed-case\">AOPP<\/jats:styled-content>), as well as apoptosis rate. Real\u2010time polymerase chain reaction was adopted to measure the expressions of superoxide dismutase\u20101 (<jats:styled-content style=\"fixed-case\">S<\/jats:styled-content>od\u20101), glutathione peroxidase\u20101 (<jats:styled-content style=\"fixed-case\">G<\/jats:styled-content>px\u20101) and endothelial nitric oxide synthase (e<jats:styled-content style=\"fixed-case\">NOS<\/jats:styled-content>) in placenta. Finally, western blot was performed to detect <jats:styled-content style=\"fixed-case\">P<\/jats:styled-content>\u2010glycoprotein expression.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>All isoproterenol twice\u2010treated fetuses exhibited significant (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.05) contractile dysfunction by fetal echocardiography compared to others. The <jats:styled-content style=\"fixed-case\">HE<\/jats:styled-content> staining showed severe placental hydrops in the <jats:styled-content style=\"fixed-case\">FHD<\/jats:styled-content> group, and that hydrops could be reduced by <jats:styled-content style=\"fixed-case\">VitC<\/jats:styled-content> treatment. Total antioxidant capacity and total <jats:styled-content style=\"fixed-case\">S<\/jats:styled-content>od\u20101 decreased in <jats:styled-content style=\"fixed-case\">FHD<\/jats:styled-content> and elevated after <jats:styled-content style=\"fixed-case\">VitC<\/jats:styled-content> supplementation. Also, level of <jats:styled-content style=\"fixed-case\">AOPP<\/jats:styled-content> increased in <jats:styled-content style=\"fixed-case\">FHD<\/jats:styled-content> and dropped after <jats:styled-content style=\"fixed-case\">VitC<\/jats:styled-content> supplementation. Analysis of apoptosis demonstrated that there was a mild increase in apoptosis rate of <jats:styled-content style=\"fixed-case\">FHD<\/jats:styled-content>. Reductions of <jats:styled-content style=\"fixed-case\">S<\/jats:styled-content>od\u20101 and e<jats:styled-content style=\"fixed-case\">NOS mRNA<\/jats:styled-content> expression were confirmed in <jats:styled-content style=\"fixed-case\">FHD<\/jats:styled-content>, but these could recovered after <jats:styled-content style=\"fixed-case\">VitC<\/jats:styled-content> supplementation, with the same tendency of the <jats:styled-content style=\"fixed-case\">P<\/jats:styled-content>\u2010glycoprotein.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Severe oxidative injuries were identified in placentas of <jats:styled-content style=\"fixed-case\">FHD<\/jats:styled-content> with <jats:styled-content style=\"fixed-case\">P<\/jats:styled-content>\u2010glycoprotein repression. <jats:styled-content style=\"fixed-case\">VitC<\/jats:styled-content> administration can reduce the oxidative stress and rebuild the protective mechanism of placenta.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jog.12389","type":"journal-article","created":{"date-parts":[[2014,6,3]],"date-time":"2014-06-03T03:14:07Z","timestamp":1401765247000},"page":"1632-1642","source":"Crossref","is-referenced-by-count":7,"title":["Evaluation of oxidative stress in placenta of fetal cardiac dysfunction rat model and antioxidant defenses of maternal vitamin <scp>C<\/scp> supplementation with the impacts on <scp>P<\/scp>\u2010glycoprotein"],"prefix":"10.1111","volume":"40","author":[{"given":"Yifei","family":"Li","sequence":"first","affiliation":[{"name":"Department of Pediatric Cardiovascular Disease Ministry of Education Key Laboratory of Women and Children's Diseases and Birth Defects"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jie","family":"Fang","sequence":"additional","affiliation":[{"name":"West China Stomatology Hospital Sichuan University  Chengdu Sichuan 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