{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T17:27:54Z","timestamp":1777483674286,"version":"3.51.4"},"reference-count":13,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2014,6,2]],"date-time":"2014-06-02T00:00:00Z","timestamp":1401667200000},"content-version":"vor","delay-in-days":1,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Obstet and Gynaecol"],"published-print":{"date-parts":[[2014,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>Chronic abruption\u2013oligohydramnios sequence (<jats:styled-content style=\"fixed-case\">CAOS<\/jats:styled-content>) is a clinical condition with lasting vaginal bleeding and oligohydramnios because of chronic placental abruption, which seems to cause preterm labor and neonatal chronic lung disease (<jats:styled-content style=\"fixed-case\">CLD<\/jats:styled-content>). This prompted us to explore the correlation between perinatal\/neonatal outcomes and <jats:styled-content style=\"fixed-case\">CAOS<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Patients with suspected risk of abortion with recurrent vaginal bleeding were divided into <jats:styled-content style=\"fixed-case\">CAOS<\/jats:styled-content> and non\u2010<jats:styled-content style=\"fixed-case\">CAOS<\/jats:styled-content> groups, and we compared the perinatal\/neonatal outcomes between these two groups. To examine the impact of chorioamnionitis (<jats:styled-content style=\"fixed-case\">CAM<\/jats:styled-content>) on the prognosis of <jats:styled-content style=\"fixed-case\">CAOS<\/jats:styled-content>, we also compared outcomes between the <jats:styled-content style=\"fixed-case\">CAOS<\/jats:styled-content> group and gestational\u2010age\u2010matched preterm labor due to <jats:styled-content style=\"fixed-case\">CAM<\/jats:styled-content> (<jats:styled-content style=\"fixed-case\">CAM<\/jats:styled-content> group).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In the <jats:styled-content style=\"fixed-case\">CAOS<\/jats:styled-content> and non\u2010<jats:styled-content style=\"fixed-case\">CAOS<\/jats:styled-content> groups, initial vaginal bleeding was seen at the first trimester. However, its duration was significantly longer in the <jats:styled-content style=\"fixed-case\">CAOS<\/jats:styled-content> group. Additionally, neonatal birthweight was lower, and small\u2010for\u2010gestational\u2010age (<jats:styled-content style=\"fixed-case\">SGA<\/jats:styled-content>) incidence was higher in the <jats:styled-content style=\"fixed-case\">CAOS<\/jats:styled-content> group. <jats:styled-content style=\"fixed-case\">CLD<\/jats:styled-content> was observed in most infants from <jats:styled-content style=\"fixed-case\">CAOS<\/jats:styled-content> patients. In the comparison between <jats:styled-content style=\"fixed-case\">CAOS<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">CAM<\/jats:styled-content> groups, birthweight was lower and <jats:styled-content style=\"fixed-case\">SGA<\/jats:styled-content> incidence was higher in the <jats:styled-content style=\"fixed-case\">CAOS<\/jats:styled-content> group. Moreover, <jats:styled-content style=\"fixed-case\">CLD<\/jats:styled-content> incidence and neonatal mortality were significantly higher, despite the lower incidence of severe <jats:styled-content style=\"fixed-case\">CAM<\/jats:styled-content> in the <jats:styled-content style=\"fixed-case\">CAOS<\/jats:styled-content> group. Finally, multivariate analysis demonstrated that duration of bleeding was a significant predictive factor for <jats:styled-content style=\"fixed-case\">CAOS<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Our observations demonstrated that patients with <jats:styled-content style=\"fixed-case\">CAOS<\/jats:styled-content> were a high\u2010risk group for poor perinatal\/neonatal outcomes. Moreover, episodes of recurrent and prolonged uterine bleeding were predictive factors for <jats:styled-content style=\"fixed-case\">CAOS<\/jats:styled-content>. During the first trimester, prolonged bleeding is an important sign as one symptom of <jats:styled-content style=\"fixed-case\">CAOS<\/jats:styled-content>.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jog.12395","type":"journal-article","created":{"date-parts":[[2014,6,3]],"date-time":"2014-06-03T03:14:07Z","timestamp":1401765247000},"page":"1618-1624","source":"Crossref","is-referenced-by-count":28,"title":["Adverse perinatal and neonatal outcomes in patients with chronic abruption\u2013oligohydramnios sequence"],"prefix":"10.1111","volume":"40","author":[{"given":"Aya","family":"Kobayashi","sequence":"first","affiliation":[{"name":"Departments of <sup>1<\/sup>Obstetrics and Gynecology"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sawako","family":"Minami","sequence":"additional","affiliation":[{"name":"Departments of <sup>1<\/sup>Obstetrics and Gynecology"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuko","family":"Tanizaki","sequence":"additional","affiliation":[{"name":"Departments of <sup>1<\/sup>Obstetrics and Gynecology"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michihisa","family":"Shiro","sequence":"additional","affiliation":[{"name":"Departments of <sup>1<\/sup>Obstetrics and Gynecology"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Madoka","family":"Yamamoto","sequence":"additional","affiliation":[{"name":"Departments of <sup>1<\/sup>Obstetrics and Gynecology"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shigetaka","family":"Yagi","sequence":"additional","affiliation":[{"name":"Departments of <sup>1<\/sup>Obstetrics and Gynecology"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takahiro","family":"Okutani","sequence":"additional","affiliation":[{"name":"Perinatal Medicine Wakayama Medical University  Wakayama Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takeshi","family":"Kumagai","sequence":"additional","affiliation":[{"name":"Perinatal Medicine Wakayama Medical University  Wakayama Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ryuzo","family":"Higuchi","sequence":"additional","affiliation":[{"name":"Perinatal Medicine Wakayama Medical University  Wakayama Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kazuhiko","family":"Ino","sequence":"additional","affiliation":[{"name":"Departments of <sup>1<\/sup>Obstetrics and Gynecology"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2014,6,2]]},"reference":[{"key":"e_1_2_6_2_1","volume-title":"Williams Obstetrics","author":"Cunningham FG","year":"2009"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1093\/aje\/153.4.332"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9378(15)31292-8"},{"key":"e_1_2_6_5_1","first-page":"418","article-title":"Chronic abruption\u2010oligohydramnios sequence","volume":"43","author":"Elliott JP","year":"1998","journal-title":"J Reprod Med"},{"key":"e_1_2_6_6_1","first-page":"67","article-title":"Pathology of the placenta, membranes, and umbilical cord in bacterial, fungal, and viral infections in man","volume":"22","author":"Blanc WA","year":"1981","journal-title":"Monogr Pathol"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1442-200X.1992.tb01028.x"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1097\/00006254-198810000-00001"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajcp\/111.6.804"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9378(91)91442-Y"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-2001-13638"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s004310050971"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1136\/adc.63.2.190"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.113.4.800"}],"container-title":["Journal of Obstetrics and Gynaecology Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjog.12395","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjog.12395","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jog.12395","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,2]],"date-time":"2023-10-02T09:28:20Z","timestamp":1696238900000},"score":1,"resource":{"primary":{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/10.1111\/jog.12395"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,6]]},"references-count":13,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2014,6]]}},"alternative-id":["10.1111\/jog.12395"],"URL":"https:\/\/doi.org\/10.1111\/jog.12395","archive":["Portico"],"relation":{},"ISSN":["1341-8076","1447-0756"],"issn-type":[{"value":"1341-8076","type":"print"},{"value":"1447-0756","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,6]]}}}