{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,11]],"date-time":"2026-05-11T17:46:58Z","timestamp":1778521618853,"version":"3.51.4"},"reference-count":28,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2014,6,2]],"date-time":"2014-06-02T00:00:00Z","timestamp":1401667200000},"content-version":"vor","delay-in-days":1,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Obstet and Gynaecol"],"published-print":{"date-parts":[[2014,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>One of the important risk factors for recurrence of endometrial cancer is lymph node metastasis. The regional lymph nodes are pelvic lymph nodes (<jats:styled-content style=\"fixed-case\">PLN<\/jats:styled-content>) and para\u2010aortic lymph nodes (<jats:styled-content style=\"fixed-case\">PAN<\/jats:styled-content>). <jats:styled-content style=\"fixed-case\">PAN<\/jats:styled-content> metastasis was often detected in the cases with <jats:styled-content style=\"fixed-case\">PLN<\/jats:styled-content> metastasis. However, <jats:styled-content style=\"fixed-case\">PAN<\/jats:styled-content> metastasis not associated with <jats:styled-content style=\"fixed-case\">PLN<\/jats:styled-content> metastasis was identified in a few cases. We focused on nine cases with <jats:styled-content style=\"fixed-case\">PAN<\/jats:styled-content> metastasis and without <jats:styled-content style=\"fixed-case\">PLN<\/jats:styled-content> metastasis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Material and Methods<\/jats:title><jats:p>The subjects of this study were 260 cases that were diagnosed with endometrial cancer. The initial treatments were surgery, including pelvic and para\u2010aortic lymphadenectomy. Nine of these cases had <jats:styled-content style=\"fixed-case\">PAN<\/jats:styled-content> metastasis but did not have <jats:styled-content style=\"fixed-case\">PLN<\/jats:styled-content> metastasis. We retrospectively analyzed the clinicopathological factors and prognosis in cases with <jats:styled-content style=\"fixed-case\">PLN\u2013PAN<\/jats:styled-content>+ cases.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 91 (35%) cases were identified as positive for either <jats:styled-content style=\"fixed-case\">PLN<\/jats:styled-content> or <jats:styled-content style=\"fixed-case\">PAN<\/jats:styled-content>. <jats:styled-content style=\"fixed-case\">PAN<\/jats:styled-content> metastases were detected in 62.6% of the cases that had some regional lymph node metastases and 3.5% of all cases were <jats:styled-content style=\"fixed-case\">PLN<\/jats:styled-content>\u2013 and <jats:styled-content style=\"fixed-case\">PAN<\/jats:styled-content>+. In all <jats:styled-content style=\"fixed-case\">PLN\u2013PAN<\/jats:styled-content>+ cases, <jats:styled-content style=\"fixed-case\">PAN<\/jats:styled-content> swelling was not detected by preoperative chest\u2010abdominal computed tomography scan. There were no clear trends among risk factors of regional lymph node metastasis. The 5\u2010year progression\u2010free survival was 87.1% for <jats:styled-content style=\"fixed-case\">PLN<\/jats:styled-content>\u2212<jats:styled-content style=\"fixed-case\">PAN<\/jats:styled-content>\u2212 cases, 67.5% for <jats:styled-content style=\"fixed-case\">PLN<\/jats:styled-content>+<jats:styled-content style=\"fixed-case\">PAN<\/jats:styled-content>\u2212 cases, 44.4% for <jats:styled-content style=\"fixed-case\">PLN<\/jats:styled-content>\u2212<jats:styled-content style=\"fixed-case\">PAN<\/jats:styled-content>+ cases, and 33.2% for <jats:styled-content style=\"fixed-case\">PLN<\/jats:styled-content>+<jats:styled-content style=\"fixed-case\">PAN<\/jats:styled-content>+ cases.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>During diagnosis and treatment for endometrial cancer, <jats:styled-content style=\"fixed-case\">PLN<\/jats:styled-content>\u2212<jats:styled-content style=\"fixed-case\">PAN<\/jats:styled-content>+ cases should also be considered because the prognosis in <jats:styled-content style=\"fixed-case\">PLN\u2013PAN<\/jats:styled-content>+ cases tended to be lower than that in <jats:styled-content style=\"fixed-case\">PLN\u2013PAN<\/jats:styled-content>\u2013 cases and <jats:styled-content style=\"fixed-case\">PLN<\/jats:styled-content>+<jats:styled-content style=\"fixed-case\">PAN<\/jats:styled-content>\u2212 cases.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jog.12399","type":"journal-article","created":{"date-parts":[[2014,6,3]],"date-time":"2014-06-03T03:14:07Z","timestamp":1401765247000},"page":"1733-1739","source":"Crossref","is-referenced-by-count":16,"title":["Clinicopathological study on para\u2010aortic lymph node metastasis without pelvic lymph node metastasis in endometrial cancer"],"prefix":"10.1111","volume":"40","author":[{"given":"Shoko","family":"Tomisato","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology School of Medicine Keio University  Tokyo 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