{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,1,3]],"date-time":"2024-01-03T12:51:57Z","timestamp":1704286317774},"reference-count":21,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2014,7,23]],"date-time":"2014-07-23T00:00:00Z","timestamp":1406073600000},"content-version":"vor","delay-in-days":22,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Medical Scientific Research Funds of Guangdong Province","award":["B2012091"],"award-info":[{"award-number":["B2012091"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Obstet and Gynaecol"],"published-print":{"date-parts":[[2014,7]]},"abstract":"Abstract<\/jats:title>Aim<\/jats:title>Our aim was to analyze the effect of reducing the dose of depot gonadotrophin\u2010regulating hormone\u2010agonist (GnRH<\/jats:styled-content>\u2010a) to 1.0\u2009mg on pituitary desensitization and clinical outcome of in vitro<\/jats:italic> fertilization and embryo transfer cycles.<\/jats:p><\/jats:sec>Material and Methods<\/jats:title>This retrospective self\u2010control study was conducted on 143 patients who underwent repeated long\u2010protocol treatment from 1 J<\/jats:styled-content>anuary 2011 to 31 M<\/jats:styled-content>ay 2012 at our hospital. Of the 143 patients, 64 received reduced\u2010dose depot (1.0\u2009mg diphereline depot) GnRH<\/jats:styled-content>\u2010a for the first cycle and short\u2010acting GnRH<\/jats:styled-content>\u2010a (0.05\u2009mg diphereline) for the second cycle, while 79 patients received short\u2010acting GnRH<\/jats:styled-content>\u2010a for the first cycle and reduced\u2010dose depot GnRH<\/jats:styled-content>\u2010a for the second cycle.<\/jats:p><\/jats:sec>Results<\/jats:title>The serum follicle\u2010stimulating hormone, luteinizing hormone and estradiol levels on the day of gonadotrophin initiation were significantly higher in the short\u2010acting group compared with the long\u2010acting group. Both number of days of gonadotrophin stimulation and gonadotrophin doses were significantly higher in the short\u2010acting group. On the day of human chorionic gonadotrophin administration, the serum estradiol level was significantly higher while the progesterone level was significantly lower in the short\u2010acting group. There were no significant differences with regard to the number of retrieved oocytes, fertilization rate, number of transferred embryos, clinical pregnancy rate, implantation rate, and early pregnancy loss rate between the two groups. However, the oocyte maturation rate was significantly higher in the long\u2010acting group.<\/jats:p><\/jats:sec>Conclusion<\/jats:title>Reduced\u2010dose depot GnRH<\/jats:styled-content>\u2010a can be successfully used for pituitary desensitization in in vitro<\/jats:italic> fertilization and embryo transfer. Deeper downregulation with reduced\u2010dose depot GnRH<\/jats:styled-content>\u2010a indicates that the optimal dose of GnRH<\/jats:styled-content>\u2010a warrants future study.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jog.12417","type":"journal-article","created":{"date-parts":[[2014,7,23]],"date-time":"2014-07-23T14:25:19Z","timestamp":1406125519000},"page":"1901-1906","source":"Crossref","is-referenced-by-count":6,"title":["Self\u2010control study on reduced\u2010dose depot versus daily administration of gonadotrophin\u2010releasing hormone agonists for pituitary desensitization in in vitro<\/i> fertilization cycles"],"prefix":"10.1111","volume":"40","author":[{"given":"Jun","family":"Gao","sequence":"first","affiliation":[{"name":"Reproductive Center First Affiliated Hospital, Sun Yat\u2010sen University Guangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yan\u2010Wen","family":"Xu","sequence":"additional","affiliation":[{"name":"Reproductive Center 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