{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T14:50:00Z","timestamp":1792075800452,"version":"4.4.0"},"reference-count":26,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2014,7,23]],"date-time":"2014-07-23T00:00:00Z","timestamp":1406073600000},"content-version":"vor","delay-in-days":22,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Obstet and Gynaecol"],"published-print":{"date-parts":[[2014,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>The present study aims to determine whether mean platelet volume (<jats:styled-content style=\"fixed-case\">MPV<\/jats:styled-content>) specified in late first trimester of pregnancy can be used to predict pre\u2010eclampsia and intrauterine growth restriction (<jats:styled-content style=\"fixed-case\">IUGR<\/jats:styled-content>).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This study prospectively reviews 200 healthy women with 11\u201314\u2010week\u2010old pregnancies.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Average pregnancy\u2010associated plasma protein\u2010<jats:styled-content style=\"fixed-case\">A<\/jats:styled-content> (<jats:styled-content style=\"fixed-case\">PAPP<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">A<\/jats:styled-content>) multiples of the median (<jats:styled-content style=\"fixed-case\">MoM<\/jats:styled-content>) value was significantly lower and <jats:styled-content style=\"fixed-case\">MPV<\/jats:styled-content> was significantly higher in pre\u2010eclamptic pregnancies (<jats:italic>P<\/jats:italic>\u2009=\u20090.001 for both). <jats:styled-content style=\"fixed-case\">MPV<\/jats:styled-content> values of 10.5\u2009fl or more can predict pre\u2010eclampsia with 66.7% sensitivity and 63.8% specificity. The combination of <jats:styled-content style=\"fixed-case\">MPV<\/jats:styled-content> of 10.5\u2009fl or more and <jats:styled-content style=\"fixed-case\">PAPP<\/jats:styled-content>\u2010A <jats:styled-content style=\"fixed-case\">MoM<\/jats:styled-content> of 0.33 or less can predict pre\u2010eclampsia with 75% sensitivity and 70.0% specificity. <jats:styled-content style=\"fixed-case\">MPV<\/jats:styled-content> values of 10.5\u2009fl or more can predict <jats:styled-content style=\"fixed-case\">IUGR<\/jats:styled-content> with 82.4% sensitivity and 60.0% specificity. The combination of <jats:styled-content style=\"fixed-case\">MPV<\/jats:styled-content> of 10.5\u2009fl or more and <jats:styled-content style=\"fixed-case\">PAPP<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">A MoM<\/jats:styled-content> of 0.33 or less can predict <jats:styled-content style=\"fixed-case\">IUGR<\/jats:styled-content> with 85.3% sensitivity and 62.0% specificity.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Increased <jats:styled-content style=\"fixed-case\">MPV<\/jats:styled-content> reflects enhanced platelet activation which may be caused by impairment in uteroplacental circulation. When <jats:styled-content style=\"fixed-case\">MPV<\/jats:styled-content> of 10.1 or more and <jats:styled-content style=\"fixed-case\">PAPP<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">A MoM<\/jats:styled-content> of 0.33 or less are combined as a threshold, the pregnancies that are destined to develop <jats:styled-content style=\"fixed-case\">IUGR<\/jats:styled-content> and pre\u2010eclampsia can be predicted with considerably high sensitivity and specificity. The <jats:styled-content style=\"fixed-case\">MPV<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">PAPP<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">A<\/jats:styled-content> combination can be addressed as a useful biochemical tool for the prediction of <jats:styled-content style=\"fixed-case\">IUGR<\/jats:styled-content> and pre\u2010eclampsia in late first trimester.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jog.12433","type":"journal-article","created":{"date-parts":[[2014,7,23]],"date-time":"2014-07-23T14:25:19Z","timestamp":1406125519000},"page":"1840-1845","source":"Crossref","is-referenced-by-count":48,"title":["Could mean platelet volume in late first trimester of pregnancy predict intrauterine growth restriction and pre\u2010eclampsia?"],"prefix":"10.1111","volume":"40","author":[{"given":"Mine","family":"Kanat\u2010Pektas","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology Afyon Kocatepe University 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