{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,11]],"date-time":"2026-06-11T07:15:38Z","timestamp":1781162138186,"version":"3.54.1"},"reference-count":23,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2014,7,23]],"date-time":"2014-07-23T00:00:00Z","timestamp":1406073600000},"content-version":"vor","delay-in-days":22,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Obstet and Gynaecol"],"published-print":{"date-parts":[[2014,7]]},"abstract":"Abstract<\/jats:title>Aim<\/jats:title>The aim of this study was to investigate the role of fasting and postprandial total bile acids (fTBA<\/jats:styled-content>, ppTBA<\/jats:styled-content>) in prediction of adverse perinatal outcomes in intrahepatic cholestasis of pregnancy (ICP<\/jats:styled-content>).<\/jats:p><\/jats:sec>Material and Methods<\/jats:title>A total of 111 patients, 57 with ICP<\/jats:styled-content> and 54 controls, were evaluated for preterm birth (PTB<\/jats:styled-content>), meconium\u2010stained amnion (MSA<\/jats:styled-content>), neonatal intensive\u2010care unit admission and asphyxia. We further classified the ICP<\/jats:styled-content> group as mild and severe. Logistic regression was performed to evaluate the associated biochemical and clinical parameters with adverse perinatal outcomes.<\/jats:p><\/jats:sec>Results<\/jats:title>In the ICP<\/jats:styled-content> group, PTB<\/jats:styled-content>, asphyxia, admission to neonatal intensive\u2010care unit, and MSA<\/jats:styled-content> were more frequently observed (P<\/jats:italic>\u2009=\u20090.001, P<\/jats:italic>\u2009=\u20090.027, P<\/jats:italic>\u2009=\u20090.006 and P<\/jats:italic>\u2009=\u20090.030, respectively). In subgroup analysis, PTB<\/jats:styled-content> was more frequent in severe ICP<\/jats:styled-content> cases than in mild cases (P<\/jats:italic>\u2009=\u20090.028). Fasting and ppTBA<\/jats:styled-content> were positively correlated with serum aspartate aminotransferase and alanine aminotransferase levels. Postprandial TBA<\/jats:styled-content> and difference between fasting and postprandial TBA<\/jats:styled-content> levels were associated with asphyxia (P<\/jats:italic>\u2009=\u20090.014 and P<\/jats:italic>\u2009=\u20090.023, respectively). Gestational age at diagnosis and fTBA<\/jats:styled-content> were associated with adverse perinatal outcomes (P<\/jats:italic>\u2009=\u20090.001 and P<\/jats:italic>\u2009=\u20090.025, respectively).<\/jats:p><\/jats:sec>Conclusion<\/jats:title>Postprandial TBA<\/jats:styled-content> and difference of fasting and postprandial TBA<\/jats:styled-content> are associated with asphyxia in ICP<\/jats:styled-content>. The gestational age at diagnosis and fTBA<\/jats:styled-content> are associated with adverse perinatal outcomes.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jog.12444","type":"journal-article","created":{"date-parts":[[2014,7,23]],"date-time":"2014-07-23T14:25:19Z","timestamp":1406125519000},"page":"1883-1889","source":"Crossref","is-referenced-by-count":11,"title":["Role of postprandial bile acids in prediction of perinatal outcome in intrahepatic cholestasis of pregnancy"],"prefix":"10.1111","volume":"40","author":[{"given":"Ayla","family":"Sarg\u0131n Oru\u00e7","sequence":"first","affiliation":[{"name":"Zekai Tahir Burak Women's Health Education and Research Hospital Ankara Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Berna","family":"Se\u00e7kin","sequence":"additional","affiliation":[{"name":"Zekai Tahir Burak Women's Health Education and Research Hospital Ankara 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