{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,28]],"date-time":"2025-11-28T04:48:47Z","timestamp":1764305327297},"reference-count":16,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2014,7,23]],"date-time":"2014-07-23T00:00:00Z","timestamp":1406073600000},"content-version":"vor","delay-in-days":22,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Obstet and Gynaecol"],"published-print":{"date-parts":[[2014,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>It has been shown that glycolytic metabolism is increased in malignant cells. Cancer cell growth is an energy\u2010related process supported by an increased glucose metabolism. In addition, p63, a known homolog of p53, is expressed predominantly in basal cell and squamous cell carcinomas. The purpose of this study was to evaluate the expression of glucose transporter protein 1 (<jats:styled-content style=\"fixed-case\">GLUT<\/jats:styled-content>1) and p63 in patients with serous ovarian tumor (benign, borderline and malignant) and study their close relationship with the malignant transformation of serous ovarian tumors.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Two hundred formalin\u2010fixed, paraffin\u2010embedded sections were immunostained with rabbit anti\u2010<jats:styled-content style=\"fixed-case\">GLUT<\/jats:styled-content>1 polyclonal antibody and mouse anti\u2010p63 monoclonal antibody using the streptavidin\u2010biotin method. The samples were as follows: 40 normal ovarian tissues, 40 serous cystadenomas, 40 borderline serous cystadenomas and 80 serous cystadenocarcinomas were stained.<\/jats:p><\/jats:sec><jats:sec><jats:title>Result<\/jats:title><jats:p>Normal ovarian tissues showed completely negative staining for <jats:styled-content style=\"fixed-case\">GLUT<\/jats:styled-content>1 and p63. However, from benign serious cystadenomas, borderline cystadenomas to cystadenocarcinomas, the expression of <jats:styled-content style=\"fixed-case\">GLUT<\/jats:styled-content>1 and p63 grew stronger (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.05). Moreover, the intensity staining of <jats:styled-content style=\"fixed-case\">GLUT<\/jats:styled-content>1 maintained a significant association with the expression of p63 (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.05). In \u03c7<jats:sup>2<\/jats:sup>\u2010test analysis, expression of borderline cystadenomas and cystadenocarcinomas, intraperitoneal implants, ascites, lymph node status and International Federation of Gynecology and Obstetrics (<jats:styled-content style=\"fixed-case\">FIGO<\/jats:styled-content>) stage and <jats:styled-content style=\"fixed-case\">GLUT<\/jats:styled-content>1 expression levels have an appalling significance (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.05), while <jats:styled-content style=\"fixed-case\">FIGO<\/jats:styled-content> stage, intraperitoneal implants and lymph node status except patient age and ascites have a statistical significance with the expression of p63 levels (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.05).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Our findings show a progressive increase in the expression of <jats:styled-content style=\"fixed-case\">GLUT<\/jats:styled-content>1 and p63 from the benign serous cystadenomas, borderline cystadenomas to cystadenocarcinomas. Overexpression of <jats:styled-content style=\"fixed-case\">GLUT<\/jats:styled-content>1 and p63 are associated with the histology <jats:styled-content style=\"fixed-case\">FIGO<\/jats:styled-content> stage and metastasis of the tumors. These data suggested that the expression of <jats:styled-content style=\"fixed-case\">GLUT<\/jats:styled-content>1 and p63 may be closely related to the malignant transformation of serous ovarian tumors. However, the relative importance of <jats:styled-content style=\"fixed-case\">GLUT<\/jats:styled-content>1 and p63 in ovarian serous tumor development and tumorigenesis remains mostly unclear and awaits further investigation.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jog.12447","type":"journal-article","created":{"date-parts":[[2014,7,23]],"date-time":"2014-07-23T14:25:19Z","timestamp":1406125519000},"page":"1925-1930","source":"Crossref","is-referenced-by-count":13,"title":["Expression of glucose transporter protein 1 and p63 in serous ovarian tumor"],"prefix":"10.1111","volume":"40","author":[{"given":"Yu","family":"Cai","sequence":"first","affiliation":[{"name":"Department of Gynecology and Obstetrics Beijing TongRen Hospital, Capital Medical University  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jian\u2010jun","family":"Zhai","sequence":"additional","affiliation":[{"name":"Department of Gynecology and Obstetrics Beijing TongRen Hospital, Capital Medical University  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bi\u2010bo","family":"Feng","sequence":"additional","affiliation":[{"name":"Department of Gynecology and Obstetrics Beijing TongRen Hospital, Capital Medical University  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xian\u2010zhi","family":"Duan","sequence":"additional","affiliation":[{"name":"Department of Gynecology and Obstetrics Beijing TongRen Hospital, Capital Medical University  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiao\u2010jin","family":"He","sequence":"additional","affiliation":[{"name":"Department of Pathology Beijing TongRen Hospital, Capital Medical University  Beijing 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