{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,16]],"date-time":"2026-07-16T01:11:27Z","timestamp":1784164287494,"version":"3.55.0"},"reference-count":29,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2014,8,29]],"date-time":"2014-08-29T00:00:00Z","timestamp":1409270400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Obstet and Gynaecol"],"published-print":{"date-parts":[[2014,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>To report on six cases of the diagnosis and treatment of patients with complete androgen insensitivity syndrome (<jats:styled-content style=\"fixed-case\">CAIS<\/jats:styled-content>) and a review of the relevant published work.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A retrospective analysis was performed on the clinical features, diagnosis and treatment of a total of six patients with <jats:styled-content style=\"fixed-case\">CAIS<\/jats:styled-content> who were admitted to our hospital between <jats:styled-content style=\"fixed-case\">S<\/jats:styled-content>eptember 1985 and <jats:styled-content style=\"fixed-case\">J<\/jats:styled-content>une 2012. All surgical patients were examined for sex chromosomes and sex hormone levels pre\u2010 and postoperatively, respectively, and underwent lower abdominal <jats:styled-content style=\"fixed-case\">B<\/jats:styled-content> ultrasounds and pathological examinations among other tests.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Five of the patients were treated with castration, one patient aged 5 years was treated conservatively Tissue from surgical resections showed normal testicular tissue that comprised Leydig cells and Sertoli cells, and pathological examinations showed no sign of testicular cancer. Following corrective operations, postoperative complications, such as female secondary sexual characteristics, stagnation and osteoporosis, have not developed. Sex hormone level ratio changed significantly after being treated with castration compared with preoperative levels; mainly testosterone and estrogen decreased significantly (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.05), while luteinizing hormone and follicle\u2010stimulating hormone significantly increased (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.05). However, prolactin did not change significantly (<jats:italic>P<\/jats:italic>\u2009&gt;\u20090.05).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The study show that removal of the testes in <jats:styled-content style=\"fixed-case\">CAIS<\/jats:styled-content> patients after puberty is safe and reliable. Meanwhile, it is essential to provide a hormone drug after being treated with castration. Further studies are needed to evaluate the safety and the quality of life for <jats:styled-content style=\"fixed-case\">CAIS<\/jats:styled-content> patients.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jog.12455","type":"journal-article","created":{"date-parts":[[2014,8,29]],"date-time":"2014-08-29T07:45:41Z","timestamp":1409298341000},"page":"2044-2050","source":"Crossref","is-referenced-by-count":5,"title":["Complete androgen insensitivity syndrome in juveniles and adults with female phenotypes"],"prefix":"10.1111","volume":"40","author":[{"given":"Zhou","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Urology Shanghai Sixth People's Hospital Shanghai Jiaotong University  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying\u2010Long","family":"Sa","sequence":"additional","affiliation":[{"name":"Department of Urology Shanghai Sixth People's Hospital Shanghai Jiaotong University  Shanghai 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