{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,21]],"date-time":"2026-08-21T12:10:27Z","timestamp":1787314227344,"version":"build-2736575974"},"reference-count":46,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2014,9,2]],"date-time":"2014-09-02T00:00:00Z","timestamp":1409616000000},"content-version":"vor","delay-in-days":1,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Obstet and Gynaecol"],"published-print":{"date-parts":[[2014,9]]},"abstract":"Abstract<\/jats:title>\n \n Aim<\/jats:title>\n \n The aim of this study was to retrospectively report our experience (efficacy\/morbidity) with cytoreductive surgery+hyperthermic intraperitoneal chemotherapy (\n CRS<\/jats:styled-content>\n +\n HIPEC<\/jats:styled-content>\n ) for the management of recurrent\/relapsed ovarian granulosa cell tumors (\n OGCT<\/jats:styled-content>\n ).\n <\/jats:p>\n <\/jats:sec>\n \n Material and Methods<\/jats:title>\n \n From 2010 to 2013, six patients underwent\n CRS<\/jats:styled-content>\n +\n HIPEC<\/jats:styled-content>\n .\n CRS<\/jats:styled-content>\n was performed with standard peritonectomy procedures and visceral resections directed towards complete elimination of tumors from the abdominopelvic cavity.\n HIPEC<\/jats:styled-content>\n was performed with cisplatin (50\u2009mg\/m\n 2<\/jats:sup>\n ) and doxorubicin (15\u2009mg\/m\n 2<\/jats:sup>\n ) and allowed to circulate in the abdominopelvic cavity for 90\u2009min at 41.0\u201342.2\u00b0C.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n Cytoreduction completeness (\n CC<\/jats:styled-content>\n \u20100) was achieved in all except one patient (\n CC<\/jats:styled-content>\n \u20101). Five patients had\n OGCT<\/jats:styled-content>\n recurrences in abdomen+pelvis and one patient in abdomen only. No grade\n V<\/jats:styled-content>\n morbidity (\n C<\/jats:styled-content>\n lavien\u2013\n D<\/jats:styled-content>\n indo classification) occurred. Two patients developed lung atelectasis, which was managed by mere chest physiotherapy (grade I). One patient developed urinary tract infection (grade II) and another patient developed pneumonia (grade II) \u2013 both of which were managed by antibiotics. One patient developed splenic bed and anterior abdominal wall collections requiring ultrasound\u2010guided aspiration without general anesthesia (grade III). One patient developed pulmonary embolism requiring intensive care\u2010unit management (grade IV). Four chemo\u2010na\u00efve patients received adjuvant chemotherapy whereas the remaining two previously chemo\u2010exposed patients received no adjuvant therapy. All patients were alive and disease\u2010free without proof of recurrence\/relapse at 40, 32, 27, 24, 20 and 16 months. The average interval of follow\u2010up after\n CRS<\/jats:styled-content>\n +\n HIPEC<\/jats:styled-content>\n was roughly 27 months (range: 16\u201340 months).\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n \n CRS<\/jats:styled-content>\n +\n HIPEC<\/jats:styled-content>\n appears to be an efficacious and morbidly well\u2010tolerated therapeutic modality for recurrent\/relapsed\n OGCT<\/jats:styled-content>\n . Long\u2010term follow\u2010up data and further research are needed.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/jog.12460","type":"journal-article","created":{"date-parts":[[2014,9,2]],"date-time":"2014-09-02T10:10:06Z","timestamp":1409652606000},"page":"2066-2075","source":"Crossref","is-referenced-by-count":21,"title":["Cytoreductive surgery and hyperthermic intraperitoneal chemotherapy for management of recurrent\/relapsed ovarian granulosa cell tumor: A single\u2010center experience"],"prefix":"10.1111","volume":"40","author":[{"given":"Ismail A.","family":"Al\u2010Badawi","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology King Faisal Specialist Hospital and Research Center Riyadh Saudi Arabia"},{"name":"College of Medicine Alfaisal University Riyadh Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahmed","family":"Abu\u2010Zaid","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology King Faisal Specialist Hospital and Research Center Riyadh Saudi Arabia"},{"name":"College of Medicine Alfaisal University Riyadh Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ayman","family":"Azzam","sequence":"additional","affiliation":[{"name":"Oncology Center King Faisal Specialist Hospital and Research Center Riyadh Saudi Arabia"},{"name":"Faculty of Medicine Alexandria University Alexandria Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Osama","family":"AlOmar","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology King Faisal Specialist Hospital and Research Center Riyadh Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hamed","family":"AlHusaini","sequence":"additional","affiliation":[{"name":"Oncology Center King Faisal Specialist Hospital and Research Center Riyadh Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tarek","family":"Amin","sequence":"additional","affiliation":[{"name":"Oncology Center King Faisal Specialist Hospital and Research Center Riyadh Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,9,2]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ctrv.2007.08.007"},{"key":"e_1_2_7_3_1","first-page":"231","article-title":"Clinicopathologic review of 118 granulosa and 82 theca cell tumors","volume":"55","author":"Evans AT","year":"1980","journal-title":"Obstet Gynecol"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/0090-8258(81)90040-8"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1525-1438.2007.01065.x"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1006\/gyno.1994.1010"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1701-2163(16)30464-9"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejogrb.2013.06.041"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygyno.2013.04.047"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1525-1438.2002.01067.x"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1525-1438.2007.01049.x"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00268-007-9146-8"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD005340.pub2"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/s004230050246"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000658-199501000-00004"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.sla.0000133083.54934.ae"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2007.11.1005"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2003.10.019"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygyno.2010.06.031"},{"key":"e_1_2_7_20_1","first-page":"1223","article-title":"Granulosa cell tumor of the ovary: 10 years follow\u2010up data of","volume":"24","author":"Sehouli J","year":"2004","journal-title":"Anticancer Res"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygyno.2011.10.015"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1053\/ctrv.2001.0232"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1245\/ASO.2003.08.006"},{"key":"e_1_2_7_24_1","first-page":"210","article-title":"Peritoneal carcinomatosis. 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