{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,13]],"date-time":"2025-10-13T04:11:20Z","timestamp":1760328680093},"reference-count":38,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2014,11,5]],"date-time":"2014-11-05T00:00:00Z","timestamp":1415145600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Obstet and Gynaecol"],"published-print":{"date-parts":[[2015,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>The aim of this study was to evaluate the response of women over 45 years with overactive bladder and detrusor overactivity to a 12\u2010week course of oxybutynin or tolterodine treatment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Material and Methods<\/jats:title><jats:p>A total of 301 eligible <jats:styled-content style=\"fixed-case\">I<\/jats:styled-content>ranian women were studied. In this double\u2010blinded trial, data were analyzed from 3\u2010day urinary diaries from before and after 12 weeks of treatment in which patients were randomly assigned to receive oxybutynin or tolterodine in recommended doses. Patients' convenience and the drugs' side\u2010effects were assessed by a monthly clinical appointment. End\u2010points were changed from baseline to week 12 in bladder\u2010diary variables and all observed or reported adverse events. The effectiveness of each drug was studied using the paired <jats:italic>t<\/jats:italic>\u2010test and improvement after treatment between the two groups was compared by independent <jats:italic>t<\/jats:italic>\u2010test.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Mean improvements in the terms of urgency (<jats:italic>P<\/jats:italic>\u2009=\u20090.64) and urge incontinence (<jats:italic>P<\/jats:italic>\u2009=\u20090.75) showed an insignificantly larger score in patients who were treated by oxybutynin. Improvement in night\u2010time urinary urgency and nocturia (41.2% and 54.3% vs 39.7% and 40.1% in oxybutynin vs tolterodine groups, respectively) were shown to be more improved by tolterodine in comparison to oxybutynin (<jats:italic>P<\/jats:italic>\u2009=\u20090.72 and 0.04 for night\u2010time urinary urgency and nocturia, respectively). Discontinuation of treatment due to adverse events was not significantly different in the two groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Oxybutynin and tolterodine showed similar efficacy on daytime symptoms of overactive bladder and similar side\u2010effects in perimenopausal patients. For patients with the chief complaint of nocturnal frequency, prescription of tolterodine is preferably suggested.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jog.12483","type":"journal-article","created":{"date-parts":[[2014,11,5]],"date-time":"2014-11-05T10:37:25Z","timestamp":1415183845000},"page":"120-126","source":"Crossref","is-referenced-by-count":3,"title":["Considering the prominent complaint as a guide in medical therapy for overactive bladder syndrome in women over 45 years"],"prefix":"10.1111","volume":"41","author":[{"given":"Mina","family":"Jafarabadi","sequence":"first","affiliation":[{"name":"Reproductive Health Research Center Tehran University of Medical Sciences  Tehran Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ladan","family":"Jafarabadi","sequence":"additional","affiliation":[{"name":"Reproductive Health Research Center Tehran University of Medical Sciences  Tehran Iran"},{"name":"Hormozgan University of Medical Sciences  Bandar Abas Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mamak","family":"Shariat","sequence":"additional","affiliation":[{"name":"Reproductive Health Research Center Tehran University of Medical Sciences  Tehran Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gelareh","family":"Rabie Salehi","sequence":"additional","affiliation":[{"name":"Young Researchers' Club Tehran Medical Branch Islamic Azad University  Tehran Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fedyeh","family":"Haghollahi","sequence":"additional","affiliation":[{"name":"Reproductive Health Research Center Tehran University of Medical Sciences  Tehran Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Batool Hossein","family":"Rashidi","sequence":"additional","affiliation":[{"name":"Reproductive Health Research Center Tehran University of Medical Sciences  Tehran Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2014,11,5]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.3109\/00016348409155509"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.maturitas.2004.09.001"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0039-6109(16)44631-1"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00192-008-0687-7"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.ju.0000050305.05345.40"},{"key":"e_1_2_7_7_1","volume-title":"Urinary Incontinence in Adults: Acute and Chronic Management","author":"Fantl JA","year":"1996"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.3109\/02813439209014044"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.326.7394.841"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(03)00622-7"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.2165\/00003495-200464150-00003"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1023\/A:1021372426421"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0302-2838(02)00177-X"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/PL00007094"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1592\/phco.20.5.470.35064"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.4065\/78.6.687"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.2165\/00002512-200724040-00005"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0378-5122(00)00111-0"},{"issue":"4","key":"e_1_2_7_19_1","first-page":"S158","article-title":"Safety and tolerability of tolterodine for the treatment of overactive bladder in adults","volume":"11","author":"Roberts RG","year":"2005","journal-title":"Am J Manag Care"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1345\/aph.19176"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1464-410X.2012.11652.x"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1464-410X.1990.tb14855.x"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.juro.2007.03.117"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1464-410x.2001.02228.x"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1701-2163(16)35440-8"},{"key":"e_1_2_7_26_1","unstructured":"McDonaghMS SeloverD SantaJ LopezS(eds).Drug Class Review on Agents for Overactive Bladder: Final Report[Internet]. 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