{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,20]],"date-time":"2026-07-20T19:08:39Z","timestamp":1784574519086,"version":"3.55.0"},"reference-count":23,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2014,8,11]],"date-time":"2014-08-11T00:00:00Z","timestamp":1407715200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Obstet and Gynaecol"],"published-print":{"date-parts":[[2015,1]]},"abstract":"Abstract<\/jats:title>Aim<\/jats:title>The aim of our study was to evaluate the values of platelet count and mean platelet volume (MPV<\/jats:styled-content>) obtained from maternal serum during the first trimester to predict subsequent preterm premature rupture of membranes (PPROM<\/jats:styled-content>).<\/jats:p><\/jats:sec>Material and Methods<\/jats:title>The records of 318 women with PPROM<\/jats:styled-content> and 384 healthy controls in a single center between 2009 and 2013 were retrospectively evaluated. Platelet count and MPV<\/jats:styled-content> values between 7 and 14 weeks of gestation were compared. Receiver\u2013operator curve analysis was performed to identify the optimal platelet count and MPV<\/jats:styled-content> cut\u2010off levels predicting PPROM<\/jats:styled-content>.<\/jats:p><\/jats:sec>Results<\/jats:title>Compared with controls, women with PPROM<\/jats:styled-content> had significantly increased levels of platelet count and significantly decreased levels of MPV<\/jats:styled-content> in the first trimester (P<\/jats:italic>\u2009<\u20090.001). The area under the receiver\u2013operator curve was 0.642 for MPV<\/jats:styled-content> and 0.579 for platelet count. The cut\u2010off values of MPV\u2009<\/jats:styled-content>\u2264\u20098.6\u2009fL<\/jats:styled-content> and platelet count \u2265216\u2009\u00d7\u2009103<\/jats:sup>\/\u03bcL predicted PPROM<\/jats:styled-content> with a sensitivity of 58% and 65% and specificity of 62% and 44%, respectively.<\/jats:p><\/jats:sec>Conclusion<\/jats:title>MPV<\/jats:styled-content> can be used as a more efficient predictor for an early diagnosis of PPROM<\/jats:styled-content> than platelet count. However, further research combining other markers is needed to increase the efficiency of prediction.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jog.12484","type":"journal-article","created":{"date-parts":[[2014,8,11]],"date-time":"2014-08-11T11:36:39Z","timestamp":1407756999000},"page":"23-28","source":"Crossref","is-referenced-by-count":29,"title":["Can platelet count and mean platelet volume during the first trimester of pregnancy predict preterm premature rupture of membranes?"],"prefix":"10.1111","volume":"41","author":[{"given":"Atalay","family":"Ekin","sequence":"first","affiliation":[{"name":"Department of Perinatology Izmir Tepecik Training and Research Hospital Izmir Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cenk","family":"Gezer","sequence":"additional","affiliation":[{"name":"Department of Perinatology Izmir Tepecik Training and Research Hospital Izmir 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