{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T22:42:21Z","timestamp":1777416141081,"version":"3.51.4"},"reference-count":10,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2014,8,28]],"date-time":"2014-08-28T00:00:00Z","timestamp":1409184000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Obstet and Gynaecol"],"published-print":{"date-parts":[[2015,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>We report a case of non\u2010mosaic trisomy 20 detected prenatally by amniocentesis during the 16th week of pregnancy. Fetal blood sampling showed a normal karyotype and no fetal, neonatal or infant abnormalities were observed. Amniotic fluid cell karyotyping revealed a trisomy 20 (47,<jats:styled-content style=\"fixed-case\">XY<\/jats:styled-content>,+20) with 100% trisomic cells (38\/38); however, a subsequent cordocentesis revealed a normal male karyotype. Moreover, a follow\u2010up ultrasonographic examination did not reveal any major congenital malformations, and a healthy male infant was delivered subsequently at an appropriate gestational age without obvious anomalies. Cytogenetic analysis of blood lymphocytes from the infant revealed a normal karyotype, but cultured cells from the term placenta showed a mosaic karyotype 47,<jats:styled-content style=\"fixed-case\">XY<\/jats:styled-content>,+20\/46,<jats:styled-content style=\"fixed-case\">XY<\/jats:styled-content> with 88% trisomic cells (44 of 50). Furthermore, no anomalies or developmental delays were observed in the neonatal period, thus suggesting two possibilities: confined placental mosaicism with the presence of normal and abnormal cell lineages, or generalized mosaicism affecting a limited number of tissues in both the placenta and fetus.<\/jats:p>","DOI":"10.1111\/jog.12488","type":"journal-article","created":{"date-parts":[[2014,8,28]],"date-time":"2014-08-28T06:18:03Z","timestamp":1409206683000},"page":"141-144","source":"Crossref","is-referenced-by-count":4,"title":["Case of non\u2010mosaic trisomy 20 in amniotic fluid cultures without anomalies in the fetus: Cytogenetic discrepancy between amniocytes and fetal blood"],"prefix":"10.1111","volume":"41","author":[{"given":"Kazuhisa","family":"Maeda","sequence":"first","affiliation":[{"name":"Shikoku Medical Center for Children and Adults General Perinatal Medical Center  Zentsuji Japan"},{"name":"Department of Obstetrics and Gynecology Tokushima University Hospital  Tokushima Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Issei","family":"Imoto","sequence":"additional","affiliation":[{"name":"Department of Human Genetics, Institute of Health Biosciences The University of Tokushima Graduate School  Tokushima Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takashi","family":"Kaji","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Tokushima University Hospital  Tokushima Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yukiko","family":"Yoshida","sequence":"additional","affiliation":[{"name":"Department of Human Genetics, Institute of Health Biosciences The University of Tokushima Graduate School  Tokushima Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Soichiro","family":"Nakayama","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Tokushima University Hospital  Tokushima Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Minoru","family":"Irahara","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Tokushima University Hospital  Tokushima Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2014,8,28]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/pd.1970040710"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/pd.1970070809"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/pd.169"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmg.2010.03.007"},{"key":"e_1_2_5_6_1","first-page":"543","article-title":"Non\u2010mosaic trisomy 20 in cultures of amniotic fluid from a fetus with serious congenital malformation","volume":"91","author":"Hsieh CC","year":"1992","journal-title":"J Formos Med Assoc"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/pd.2147"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.a.32338"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0223(199610)16:10<893::AID-PD962>3.0.CO;2-M"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/pd.1121"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/pd.483"}],"container-title":["Journal of Obstetrics and Gynaecology Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjog.12488","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjog.12488","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jog.12488","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,5]],"date-time":"2023-10-05T04:36:05Z","timestamp":1696480565000},"score":1,"resource":{"primary":{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/10.1111\/jog.12488"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,8,28]]},"references-count":10,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2015,1]]}},"alternative-id":["10.1111\/jog.12488"],"URL":"https:\/\/doi.org\/10.1111\/jog.12488","archive":["Portico"],"relation":{},"ISSN":["1341-8076","1447-0756"],"issn-type":[{"value":"1341-8076","type":"print"},{"value":"1447-0756","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,8,28]]}}}