{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,2]],"date-time":"2025-11-02T16:39:50Z","timestamp":1762101590735},"reference-count":26,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2014,8,27]],"date-time":"2014-08-27T00:00:00Z","timestamp":1409097600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Obstet and Gynaecol"],"published-print":{"date-parts":[[2015,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>The aim of this work was to assess the risk of early fetal loss (first trimester of pregnancy, 8\u201313\u2009weeks of gestation) using the results of first\u2010trimester screening (<jats:styled-content style=\"fixed-case\">FTS<\/jats:styled-content>) biochemical markers independently and combined.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p><jats:styled-content style=\"fixed-case\">FTS<\/jats:styled-content> results of 152 women who suffered early fetal loss were compared to a control group of 150 women with normal pregnancy outcomes. <jats:styled-content style=\"fixed-case\">FTS<\/jats:styled-content> biochemical markers were measured with a <jats:styled-content style=\"fixed-case\">D<\/jats:styled-content>elfia <jats:styled-content style=\"fixed-case\">X<\/jats:styled-content>press 6000 analyzer and biochemical risks for <jats:styled-content style=\"fixed-case\">D<\/jats:styled-content>own's and <jats:styled-content style=\"fixed-case\">E<\/jats:styled-content>dward's syndromes were calculated using <jats:styled-content style=\"fixed-case\">P<\/jats:styled-content>renatal\u2010<jats:styled-content style=\"fixed-case\">L<\/jats:styled-content>ifecycle version 3.0 software. Marker levels were standardized by calculating the gestational\u2010specific multiple of the medians (<jats:styled-content style=\"fixed-case\">MoM<\/jats:styled-content>), further adjusted by maternal age, maternal weight, cigarette consumption and pre\u2010existing type 1 diabetes mellitus. Receiver\u2013operator curves were built to evaluate each marker and its combination.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Our results show that values of biochemical risk of t21 of more than 1 in 310 have a poor sensitivity to predict early fetal loss (31.4%) with a positive predictive value (<jats:styled-content style=\"fixed-case\">PPV<\/jats:styled-content>) for fetal loss of 67.7%. Values of pregnancy\u2010associated plasma protein <jats:styled-content style=\"fixed-case\">A<\/jats:styled-content> (<jats:styled-content style=\"fixed-case\">PAPP\u2010A) MoM<\/jats:styled-content> of less than 0.48 show a sensitivity of 62.1% and a <jats:styled-content style=\"fixed-case\">PPV<\/jats:styled-content> of 84.5% for early fetal loss; whereas for free \u03b2\u2010human chorionic gonadotropin, values of <jats:styled-content style=\"fixed-case\">MoM<\/jats:styled-content> of less than 0.44 have a sensitivity of 66.4% with a <jats:styled-content style=\"fixed-case\">PPV<\/jats:styled-content> of 85.3%. A novel algorithm, consisting in the multiplication of both markers, shows for values of less than 0.48 a sensitivity of 83.1%, a specificity of 78.7% and a <jats:styled-content style=\"fixed-case\">PPV<\/jats:styled-content> of 77.1%.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Combined analysis of <jats:styled-content style=\"fixed-case\">PAPP\u2010A<\/jats:styled-content> and free \u03b2\u2010<jats:styled-content style=\"fixed-case\">hCG<\/jats:styled-content> appears to be a potential candidate to predict early fetal loss.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jog.12490","type":"journal-article","created":{"date-parts":[[2014,8,27]],"date-time":"2014-08-27T09:12:59Z","timestamp":1409130779000},"page":"69-76","source":"Crossref","is-referenced-by-count":7,"title":["First\u2010trimester screening biochemical markers (free beta\u2010subunit human chorionic gonadotropin, pregnancy\u2010associated plasma protein\u2010<scp>A<\/scp>) and risk of early fetal 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