{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,8]],"date-time":"2026-01-08T07:33:26Z","timestamp":1767857606678,"version":"3.49.0"},"reference-count":19,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2014,9,17]],"date-time":"2014-09-17T00:00:00Z","timestamp":1410912000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Siriraj Grant for Research and Development Fund, Faculty of Medicine Siriraj Hospital, Mahidol University"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Obstet and Gynaecol"],"published-print":{"date-parts":[[2015,2]]},"abstract":"Abstract<\/jats:title>Aim<\/jats:title>To evaluate the performance of ovarian stromal area to total ovarian area (S<\/jats:styled-content>\/A<\/jats:styled-content>) ratio for the prediction of biochemical hyperandrogenism in T<\/jats:styled-content>hai women with polycystic ovary syndrome (PCOS<\/jats:styled-content>).<\/jats:p><\/jats:sec>Methods<\/jats:title>A cross\u2010sectional study was performed in 222 reproductive\u2010aged T<\/jats:styled-content>hai women with PCOS<\/jats:styled-content> attending the G<\/jats:styled-content>ynecologic E<\/jats:styled-content>ndocrinology U<\/jats:styled-content>nit (GEU<\/jats:styled-content>), D<\/jats:styled-content>epartment of O<\/jats:styled-content>bstetrics and G<\/jats:styled-content>ynecology, F<\/jats:styled-content>aculty of M<\/jats:styled-content>edicine S<\/jats:styled-content>iriraj H<\/jats:styled-content>ospital from M<\/jats:styled-content>ay 2007 to J<\/jats:styled-content>anuary 2009. The patients were interviewed for medical history and examined for anthropometry and clinical hyperandrogenism. Venous blood samples were obtained for androgen profiles. An ovarian ultrasonogram was obtained via transvaginal or transrectal ultrasonography.<\/jats:p><\/jats:sec>Results<\/jats:title>The prevalences of clinical and biochemical hyperandrogenism were 48.6% and 81.1%, respectively. The S<\/jats:styled-content>\/A<\/jats:styled-content> ratio at a cut\u2010off point of 0.33 had modest predictability for hyperandrogenism, namely, 0.537 area under the receiver\u2013operator curve, 36.6% sensitivity, 72.1% specificity, 83.8% positive predictive value (PPV<\/jats:styled-content>) and 20.9% negative predictive value (NPV<\/jats:styled-content>). The combination of clinical hyperandrogenism and S<\/jats:styled-content>\/A<\/jats:styled-content> ratio improved the predictability for biochemical hyperandrogenism, with sensitivity, specificity, PPV<\/jats:styled-content> and NPV<\/jats:styled-content> of 72.1%, 58.1%, 87.8% and 33.3%, respectively.<\/jats:p><\/jats:sec>Conclusion<\/jats:title>The S<\/jats:styled-content>\/A<\/jats:styled-content> ratio alone is not a good predictor for biochemical hyperandrogenism in T<\/jats:styled-content>hai PCOS<\/jats:styled-content> women attending GEU<\/jats:styled-content> for menstrual dysfunction. The combination of S<\/jats:styled-content>\/A<\/jats:styled-content> ratio and clinical hyperandrogenism has better performance than the S<\/jats:styled-content>\/A<\/jats:styled-content> ratio alone to predict biochemical hyperandrogenism.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jog.12514","type":"journal-article","created":{"date-parts":[[2014,9,17]],"date-time":"2014-09-17T05:51:06Z","timestamp":1410933066000},"page":"248-253","source":"Crossref","is-referenced-by-count":10,"title":["Ratio of ovarian stroma and total ovarian area by ultrasound in prediction of hyperandrogenemia in reproductive\u2010aged Thai women with polycystic ovary syndrome: A diagnostic test"],"prefix":"10.1111","volume":"41","author":[{"given":"Pichai","family":"Leerasiri","sequence":"first","affiliation":[{"name":"Gynecologic Endocrinology Unit Department of Obstetrics and Gynecology Faculty of Medicine Siriraj Hospital Mahidol University Bangkok Thailand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thanyarat","family":"Wongwananuruk","sequence":"additional","affiliation":[{"name":"Gynecologic Endocrinology Unit Department of Obstetrics and Gynecology Faculty of Medicine Siriraj Hospital Mahidol University Bangkok Thailand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Manee","family":"Rattanachaiyanont","sequence":"additional","affiliation":[{"name":"Gynecologic Endocrinology Unit Department of Obstetrics and Gynecology Faculty of Medicine Siriraj Hospital Mahidol University Bangkok Thailand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Suchada","family":"Indhavivadhana","sequence":"additional","affiliation":[{"name":"Gynecologic Endocrinology Unit Department of Obstetrics and Gynecology Faculty of Medicine Siriraj Hospital Mahidol University Bangkok Thailand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kitirat","family":"Techatraisak","sequence":"additional","affiliation":[{"name":"Gynecologic Endocrinology Unit Department of Obstetrics and Gynecology Faculty of Medicine Siriraj Hospital Mahidol University Bangkok Thailand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Surasak","family":"Angsuwathana","sequence":"additional","affiliation":[{"name":"Gynecologic Endocrinology Unit Department of Obstetrics and Gynecology Faculty of Medicine Siriraj Hospital Mahidol University Bangkok Thailand"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2014,9,17]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1447-0756.2007.00631.x"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/deh098"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2008.06.035"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2008.12.138"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2008.07.387"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00404-006-0173-8"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0015-0282(01)01919-7"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-2006-924063"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1093\/humupd\/dmg044"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/dem202"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncpendmet0789"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0190-9622(08)81045-6"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clindermatol.2006.04.004"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.beem.2006.02.004"},{"key":"e_1_2_7_16_1","first-page":"499","volume-title":"Clinical Gynecologic Endocrinology and Infertility","author":"Speroff L","year":"2005"},{"key":"e_1_2_7_17_1","unstructured":"FiersT KauffmanJM.Free & Bioavailable Testosterone Calculator 2008. [Cited 22 Feb 2009.] Available from URL:http:\/\/www.issam.ch\/freetesto.htm"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2008.09.003"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2008.01.037"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijgo.2008.05.017"}],"container-title":["Journal of Obstetrics and Gynaecology Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjog.12514","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjog.12514","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jog.12514","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,2]],"date-time":"2023-10-02T19:06:45Z","timestamp":1696273605000},"score":1,"resource":{"primary":{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/10.1111\/jog.12514"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,9,17]]},"references-count":19,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2015,2]]}},"alternative-id":["10.1111\/jog.12514"],"URL":"https:\/\/doi.org\/10.1111\/jog.12514","archive":["Portico"],"relation":{},"ISSN":["1341-8076","1447-0756"],"issn-type":[{"value":"1341-8076","type":"print"},{"value":"1447-0756","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,9,17]]}}}