{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T21:20:25Z","timestamp":1790371225236,"version":"4.1.0"},"reference-count":28,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2014,10,27]],"date-time":"2014-10-27T00:00:00Z","timestamp":1414368000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Obstet and Gynaecol"],"published-print":{"date-parts":[[2015,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>The aim of this study was to determine perinatal factors associated with cerebral palsy (<jats:styled-content style=\"fixed-case\">CP<\/jats:styled-content>) in infants treated with brain hypothermia (<jats:styled-content style=\"fixed-case\">BHT<\/jats:styled-content>).<\/jats:p><\/jats:sec><jats:sec><jats:title>Material and Methods<\/jats:title><jats:p>We carried out a retrospective review of 23 infants with hypoxic ischemic encephalopathy in whom <jats:styled-content style=\"fixed-case\">BHT<\/jats:styled-content> was applied within 6\u2009h after birth. Outcome regarding the presence or absence of <jats:styled-content style=\"fixed-case\">CP<\/jats:styled-content> was assessed at the age of 18 months. Oxygen extraction fraction (<jats:styled-content style=\"fixed-case\">OEF<\/jats:styled-content>) was measured before, during and after <jats:styled-content style=\"fixed-case\">BHT<\/jats:styled-content> at the jugular sinus.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Three infants died and 12 developed <jats:styled-content style=\"fixed-case\">CP<\/jats:styled-content> (poor outcome group). The remaining eight infants did not have <jats:styled-content style=\"fixed-case\">CP<\/jats:styled-content> at 18 months old (favorable outcome group). There were no differences in gestational age, birthweight, <jats:styled-content style=\"fixed-case\">pH<\/jats:styled-content>, base deficit, or lactate level between infants with favorable and poor outcomes. Infants with flat trace on electroencephalography on admission were less likely to have favorable outcome (0.0% [0\/8] vs 53% [8\/15], respectively, <jats:italic>P<\/jats:italic>\u2009=\u20090.02), while those with Apgar score at 10\u2009min \u22655 (57% [8\/14] vs 0.0% [0\/9], <jats:italic>P<\/jats:italic>\u2009=\u20090.007) or \u22656 (70% [7\/10] vs 7.7% [1\/13], <jats:italic>P<\/jats:italic>\u2009=\u20090.002), <jats:styled-content style=\"fixed-case\">OEF<\/jats:styled-content>\u2009\u2265\u200913.3% during <jats:styled-content style=\"fixed-case\">BHT<\/jats:styled-content> (64% [7\/11] vs 8.3% [1\/12], <jats:italic>P<\/jats:italic>\u2009=\u20090.009), and <jats:styled-content style=\"fixed-case\">OEF<\/jats:styled-content>\u2009\u2265\u200918.5% after <jats:styled-content style=\"fixed-case\">BHT<\/jats:styled-content> (73% [8\/11] vs 0.0% [0\/12], <jats:italic>P<\/jats:italic>\u2009=\u20090.002) were more likely to have favorable outcome compared with those with counterpart characteristics.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Infants with an <jats:styled-content style=\"fixed-case\">A<\/jats:styled-content>pgar score at 10\u2009min \u22655, activity on electroencephalography on admission, and higher <jats:styled-content style=\"fixed-case\">OEF<\/jats:styled-content> during and after <jats:styled-content style=\"fixed-case\">BHT<\/jats:styled-content> were likely to have a favorable outcome.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jog.12520","type":"journal-article","created":{"date-parts":[[2014,10,27]],"date-time":"2014-10-27T06:08:09Z","timestamp":1414390089000},"page":"229-237","source":"Crossref","is-referenced-by-count":12,"title":["Outcome of infants with hypoxic ischemic encephalopathy treated with brain hypothermia"],"prefix":"10.1111","volume":"41","author":[{"given":"Takuya","family":"Tokuhisa","sequence":"first","affiliation":[{"name":"Department of Neonatology Perinatal Medical Center, Kagoshima City Hospital  Kagoshima Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Satoshi","family":"Ibara","sequence":"additional","affiliation":[{"name":"Department of Neonatology Perinatal Medical Center, Kagoshima City Hospital  Kagoshima Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hisanori","family":"Minakami","sequence":"additional","affiliation":[{"name":"Department of Obstetrics Hokkaido University Graduate School of Medicine  Sapporo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshinobu","family":"Maede","sequence":"additional","affiliation":[{"name":"Department of Neonatology Perinatal Medical Center, Kagoshima City Hospital  Kagoshima Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chie","family":"Ishihara","sequence":"additional","affiliation":[{"name":"Department of Neonatology Perinatal Medical Center, Kagoshima City Hospital  Kagoshima Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takako","family":"Matsui","sequence":"additional","affiliation":[{"name":"Department of Neonatology Perinatal Medical Center, Kagoshima City Hospital  Kagoshima Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,10,27]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.earlhumdev.2012.06.008"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/jog.12036"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.3109\/00016349409013384"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9378(00)70358-9"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.317.7172.1554"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1053\/sper.2000.7079"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(05)17946-X"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMcps050929"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2007.06.003"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2008-0456"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/0013-4694(80)90402-2"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-211-85578-2_40"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.siny.2010.05.008"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.braindev.2011.06.009"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.110.2.377"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1097\/00007890-198801000-00008"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.3171\/jns.1973.39.4.0442"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/0300-9572(94)00853-8"},{"key":"e_1_2_6_20_1","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1080\/01616412.1996.11740400","article-title":"Effects of graded hypothermia on outcome from brain ischemia","volume":"18","author":"Hoffman WE","year":"1996","journal-title":"Neurol Res"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.3171\/jns.1995.83.1.0093"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.1990.00530110107027"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1447-0756.2005.00241.x"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2009-0934"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1651-2227.2009.01653.x"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2009-2938"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM200102153440701"},{"key":"e_1_2_6_28_1","doi-asserted-by":"publisher","DOI":"10.1177\/0883073807306258"},{"key":"e_1_2_6_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.braindev.2013.06.007"}],"container-title":["Journal of Obstetrics and Gynaecology Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjog.12520","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjog.12520","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jog.12520","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,2]],"date-time":"2023-10-02T19:05:49Z","timestamp":1696273549000},"score":1,"resource":{"primary":{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/10.1111\/jog.12520"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,10,27]]},"references-count":28,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2015,2]]}},"alternative-id":["10.1111\/jog.12520"],"URL":"https:\/\/doi.org\/10.1111\/jog.12520","archive":["Portico"],"relation":{},"ISSN":["1341-8076","1447-0756"],"issn-type":[{"value":"1341-8076","type":"print"},{"value":"1447-0756","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,10,27]]}}}