{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T06:00:06Z","timestamp":1790229606717,"version":"4.1.0"},"reference-count":52,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2014,9,26]],"date-time":"2014-09-26T00:00:00Z","timestamp":1411689600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Obstet and Gynaecol"],"published-print":{"date-parts":[[2015,2]]},"abstract":"Abstract<\/jats:title>Aim<\/jats:title>To compare the corticosteroidogenic enzyme activities between normal cycling non\u2010polycystic ovary syndrome (PCOS<\/jats:styled-content>), and normoandrogenic PCOS<\/jats:styled-content> (NA<\/jats:styled-content>\u2010PCOS<\/jats:styled-content>) and hyperandrogenic PCOS<\/jats:styled-content> (HA\u2010PCOS<\/jats:styled-content>) patients.<\/jats:p><\/jats:sec>Methods<\/jats:title>This cohort study was conducted at J<\/jats:styled-content>ulio M<\/jats:styled-content>uller U<\/jats:styled-content>niversity H<\/jats:styled-content>ospital and T<\/jats:styled-content>ropical I<\/jats:styled-content>nstitute of R<\/jats:styled-content>eproductive M<\/jats:styled-content>edicine and M<\/jats:styled-content>enopause, and enrolled 114 non\u2010PCOS<\/jats:styled-content> women and 355 PCOS<\/jats:styled-content> patients. The steroidogenic enzyme activities were measured using the serum steroid product\/precursor molar ratio.<\/jats:p><\/jats:sec>Results<\/jats:title>In the \u03945 pathway the 17,20 lyase activity was equally low in the NA\u2010PCOS<\/jats:styled-content> and HA\u2010PCOS<\/jats:styled-content> women compared with the non\u2010PCOS<\/jats:styled-content> women (P<\/jats:italic>\u2009<\u20090.01 and P<\/jats:italic>\u2009<\u20090.001, respectively). In the \u03944 pathway, the 17,20 lyase activity was higher only in the HA\u2010PCOS<\/jats:styled-content> group (P<\/jats:italic>\u2009<\u20090.001). The 17\u2010hydroxylase activity was the same in PCOS<\/jats:styled-content> and non\u2010PCOS<\/jats:styled-content> subjects (P<\/jats:italic>\u2009>\u20090.05). The 3\u03b2\u2010hydroxysteroid dehydrogenase II (3\u03b2\u2010HSDII<\/jats:styled-content>) activity was higher in the conversion of dehydroepiandrosterone into androstenedione in the HA\u2010PCOS<\/jats:styled-content> than in the NA\u2010PCOS<\/jats:styled-content> (P<\/jats:italic>\u2009<\u20090.05) and the non\u2010PCOS<\/jats:styled-content> patients (P<\/jats:italic>\u2009<\u20090.01). The aromatase activity was lower in the HA\u2010PCOS<\/jats:styled-content> than in the NA\u2010PCOS<\/jats:styled-content> (P<\/jats:italic>\u2009<\u20090.05) patients and non\u2010PCOS<\/jats:styled-content> subjects (P<\/jats:italic>\u2009<\u20090.01). In HA\u2010PCOS<\/jats:styled-content> subjects, the 17,20 lyase activity was related to insulin, estradiol, total testosterone concentrations and free androgen index in the \u03945 pathway. 3\u03b2\u2010HSDII<\/jats:styled-content> showed weak correlation with estradiol in the HA\u2010PCOS<\/jats:styled-content> group. Anthropometric parameters had little impact, if any, on the steroidogenic enzyme activities.<\/jats:p><\/jats:sec>Conclusion<\/jats:title>The NA\u2010PCOS<\/jats:styled-content> and HA\u2010PCOS<\/jats:styled-content> patients demonstrated different enzyme activities, and the results provided new directions for future studies including PCOS<\/jats:styled-content> patients with different phenotypes.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jog.12524","type":"journal-article","created":{"date-parts":[[2014,9,26]],"date-time":"2014-09-26T05:35:01Z","timestamp":1411709701000},"page":"254-263","source":"Crossref","is-referenced-by-count":38,"title":["Comparison of steroidogenic pathways among normoandrogenic and hyperandrogenic polycystic ovary syndrome patients and normal cycling women"],"prefix":"10.1111","volume":"41","author":[{"given":"Sebasti\u00e3o Freitas","family":"de Medeiros","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology Medical Science School \u2013 UFMT Cuiab\u00e1 Mato Grosso Brazil"},{"name":"Julio Muller University Hospital Cuiab\u00e1 Mato Grosso Brazil"},{"name":"Tropical Institute of Reproductive Medicine and Menopause Cuiab\u00e1 Mato Grosso Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacklyne Silva","family":"Barbosa","sequence":"additional","affiliation":[{"name":"Tropical Institute of Reproductive Medicine and Menopause Cuiab\u00e1 Mato Grosso Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M\u00e1rcia Marly Winck","family":"Yamamoto","sequence":"additional","affiliation":[{"name":"Julio Muller University Hospital Cuiab\u00e1 Mato Grosso Brazil"},{"name":"Tropical Institute of Reproductive Medicine and Menopause Cuiab\u00e1 Mato Grosso Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,9,26]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2265.1997.2321049.x"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2003.07.008"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF03346454"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1210\/er.2003-0030"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1590\/S0004-27302013000600005"},{"key":"e_1_2_7_7_1","first-page":"377","volume-title":"Polycystic Ovary Syndrome","author":"Zawadski JK","year":"1992"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2006-0178"},{"key":"e_1_2_7_9_1","first-page":"541","article-title":"Adrenal androgen participation in the polycystic ovary syndrome","volume":"32","author":"Gil\u2010Junior AB","year":"2010","journal-title":"Rev Bras Gynecol Obstet"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2003-032046"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2003.10.004"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0015-0282(16)53510-9"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1530\/eje.0.1370670"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.80.2.603"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1159\/000050360"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199207163270304"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.82.12.4075"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2012-1382"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1210\/jcem-57-2-320"},{"key":"e_1_2_7_20_1","volume-title":"Obesity: Preventing and Managing the Global Epidemic. 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