{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T19:36:31Z","timestamp":1790192191192,"version":"4.1.0"},"reference-count":30,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2014,9,26]],"date-time":"2014-09-26T00:00:00Z","timestamp":1411689600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Obstet and Gynaecol"],"published-print":{"date-parts":[[2015,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>To assess the role of first trimester maternal testosterone and dehydroepiandrosterone sulfate (<jats:styled-content style=\"fixed-case\">DHEA\u2010S<\/jats:styled-content>) levels in prediction of development of gestational diabetes mellitus (<jats:styled-content style=\"fixed-case\">GDM<\/jats:styled-content>).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Four hundred and fifty pregnant women were included in this prospective cohort study. All pregnant women with a singleton pregnancy who were not diabetic, had no family history of diabetes, had no history of previous <jats:styled-content style=\"fixed-case\">GDM<\/jats:styled-content>, were of white race and non\u2010smokers were enrolled. Total testosterone and <jats:styled-content style=\"fixed-case\">DHEA\u2010S<\/jats:styled-content> were measured at 11\u201314\u2009weeks of gestation. The patients were called for routine pregnancy visits and followed accordingly. Forty\u2010two patients did not come to their visits and were excluded. During gestational weeks 24\u201328, the remaining 408 patients were screened for <jats:styled-content style=\"fixed-case\">GDM<\/jats:styled-content>. The total testosterone and <jats:styled-content style=\"fixed-case\">DHEA\u2010S<\/jats:styled-content> levels were compared between patients with and without <jats:styled-content style=\"fixed-case\">GDM<\/jats:styled-content>. Regression and receiver\u2013operator curve analysis were performed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p><jats:styled-content style=\"fixed-case\">GDM<\/jats:styled-content> developed in 22 women (5.7%). Compared with women without <jats:styled-content style=\"fixed-case\">GDM<\/jats:styled-content>, first trimester total testosterone levels were higher among women in whom <jats:styled-content style=\"fixed-case\">GDM<\/jats:styled-content> subsequently developed. The <jats:styled-content style=\"fixed-case\">DHEA\u2010S<\/jats:styled-content> level did not differ. Age, total testosterone and body mass index were found to be independent predictors of <jats:styled-content style=\"fixed-case\">GDM<\/jats:styled-content> development. A total testosterone value of 0.45\u2009ng\/mL was found to predict development of <jats:styled-content style=\"fixed-case\">GDM<\/jats:styled-content> with a sensitivity of 63.6% and a specificity of 62.7%.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>First trimester total testosterone has a low testing power for <jats:styled-content style=\"fixed-case\">GDM<\/jats:styled-content> screening with low sensitivity and specificity values and cannot be used as a marker alone. It may have a role in combination with other markers.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jog.12525","type":"journal-article","created":{"date-parts":[[2014,9,26]],"date-time":"2014-09-26T05:35:29Z","timestamp":1411709729000},"page":"193-198","source":"Crossref","is-referenced-by-count":17,"title":["Role of first trimester total testosterone in prediction of subsequent gestational diabetes mellitus"],"prefix":"10.1111","volume":"41","author":[{"given":"Yavuz M.","family":"G\u00f6z\u00fckara","sequence":"first","affiliation":[{"name":"Department of Endocrinology Ministry of Health Mersin Government Hospital  Mersin Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hakan","family":"Aytan","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Faculty of Medicine Mersin University  Mersin Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Devrim","family":"Ertunc","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Faculty of Medicine Mersin University  Mersin Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ekrem C.","family":"Tok","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Faculty of Medicine Mersin University  Mersin Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fazli","family":"Demirt\u00fcrk","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Gaziosmanpasa University  Tokat Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u015eemsettin","family":"\u015eahin","sequence":"additional","affiliation":[{"name":"Department of Biochemistry Faculty of Medicine Gaziosmanpasa University  Tokat Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pelin","family":"Aytan","sequence":"additional","affiliation":[{"name":"Department of Hematology Faculty of Medicine Cukurova University  Adana Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,9,26]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1080\/09513590801948416"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.2337\/diaclin.25.2.57"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc14-S081"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.295.11.1288"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1093\/aje\/kwi148"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.2337\/diacare.17.5.405"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.2337\/diacare.25.1.55"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.77.1.56"},{"key":"e_1_2_6_10_1","doi-asserted-by":"crossref","first-page":"123","DOI":"10.2337\/diab.40.1.123","article-title":"Low sex\u2010hormone\u2010binding globulin concentration as independent risk factor for development of NIDDM. 12\u2010yr follow\u2010up of population study of women in Gothenburg, Sweden","volume":"40","author":"Lindstedt G","year":"1991","journal-title":"Diabetes"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijgo.2009.09.021"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1464-5491.2003.00985.x"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1155\/2013\/182582"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1067\/mob.2003.343"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.metabol.2004.12.011"},{"key":"e_1_2_6_16_1","doi-asserted-by":"crossref","first-page":"693","DOI":"10.2337\/diab.40.6.693","article-title":"Opposing actions of dehydroepiandrosterone and testosterone on insulin sensitivity. 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