{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,8]],"date-time":"2026-01-08T06:08:07Z","timestamp":1767852487769,"version":"3.49.0"},"reference-count":21,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2014,10,10]],"date-time":"2014-10-10T00:00:00Z","timestamp":1412899200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Obstet and Gynaecol"],"published-print":{"date-parts":[[2015,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>A 38\u2010year\u2010old woman was found to have a deep 3.3\u2010cm endometriotic nodule of the bladder, confirmed by cystoscopic resection and imaging. Ultrasound also confirmed a 2.6\u2010cm vaginal fornix implant with similar appearance to the bladder mass. The patient's primary symptoms were mild dysmenorrhea, catamenial dysuria and hematuria. The patient conceived shortly after referral and 3 months post\u2010delivery was offered surgical management but declined in favor of medical management. Dienogest 2\u2009mg once a day was started and after 16 months of treatment, more than 50% reduction in the size of the bladder nodule was seen (pretreatment: 3.3\u2009\u00d7\u20093.0\u2009\u00d7\u20092.7\u2009cm, volume: 13.9\u2009cm<jats:sup>3<\/jats:sup>; post\u2010treatment: 2.8\u2009\u00d7\u20092.3\u2009\u00d7\u20091.0\u2009cm, volume: 6.4\u2009cm<jats:sup>3<\/jats:sup>). The vaginal mass also decreased in size from a pretreatment value of 2.0\u2009\u00d7\u20092.6\u2009\u00d7\u20091.4\u2009cm (3.8\u2009cm<jats:sup>3<\/jats:sup>) to 1.1\u2009\u00d7\u20091.4\u2009\u00d7\u20090.5\u2009mm (0.40\u2009cm<jats:sup>3<\/jats:sup>) after the treatment. The patient remained asymptomatic with no significant adverse drug reaction during management. Dienogest may be one of the options for medical management of deep endometriosis in young women especially when surgical intervention is declined.<\/jats:p>","DOI":"10.1111\/jog.12527","type":"journal-article","created":{"date-parts":[[2014,10,10]],"date-time":"2014-10-10T05:38:46Z","timestamp":1412919526000},"page":"309-313","source":"Crossref","is-referenced-by-count":20,"title":["Dienogest for the treatment of deep endometriosis: Case report and literature review"],"prefix":"10.1111","volume":"41","author":[{"given":"Sugandha","family":"Agarwal","sequence":"first","affiliation":[{"name":"Departments of Obstetrics, Gynecology and Newborn Care The Ottawa Hospital\/University of Ottawa  Ottawa Ontario Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Margaret Ann","family":"Fraser","sequence":"additional","affiliation":[{"name":"Medical Imaging The Ottawa Hospital\/University of Ottawa  Ottawa Ontario 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