{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,19]],"date-time":"2026-03-19T18:40:00Z","timestamp":1773945600223,"version":"3.50.1"},"reference-count":30,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2014,10,27]],"date-time":"2014-10-27T00:00:00Z","timestamp":1414368000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Obstet and Gynaecol"],"published-print":{"date-parts":[[2015,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>Ovarian steroid cell tumors, not otherwise specified (<jats:styled-content style=\"fixed-case\">SCT\u2010NOS<\/jats:styled-content>) are very rare neoplasms. No large study has been performed in <jats:styled-content style=\"fixed-case\">P<\/jats:styled-content>akistan to establish the clinicopathological spectrum and immunohistochemical behavior in our region. The purpose of our study was to determine the various clinicopathological and immunohistochemical features of ovarian <jats:styled-content style=\"fixed-case\">SCT\u2010NOS<\/jats:styled-content> along with follow\u2010up in our institution.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This was a retrospective observational study. The study was conducted in the <jats:styled-content style=\"fixed-case\">S<\/jats:styled-content>ection of <jats:styled-content style=\"fixed-case\">H<\/jats:styled-content>istopathology, <jats:styled-content style=\"fixed-case\">A<\/jats:styled-content>ga <jats:styled-content style=\"fixed-case\">K<\/jats:styled-content>han <jats:styled-content style=\"fixed-case\">U<\/jats:styled-content>niversity <jats:styled-content style=\"fixed-case\">H<\/jats:styled-content>ospital, <jats:styled-content style=\"fixed-case\">K<\/jats:styled-content>arachi, <jats:styled-content style=\"fixed-case\">P<\/jats:styled-content>akistan. All reported cases of ovarian <jats:styled-content style=\"fixed-case\">SCT\u2010NOS<\/jats:styled-content> occurring during <jats:styled-content style=\"fixed-case\">J<\/jats:styled-content>anuary 1992 to <jats:styled-content style=\"fixed-case\">A<\/jats:styled-content>ugust 2013 were retrieved. The slides were reviewed and patient demographics, and clinical and pathological features were noted with proforma software. <jats:styled-content style=\"fixed-case\">SPSS<\/jats:styled-content> version 19 was used for all analyses. Data is expressed as absolute values and percentages.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 12 <jats:styled-content style=\"fixed-case\">SCT<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">NOS<\/jats:styled-content> (2.3%) out of 528 ovarian sex cord stromal tumors were retrieved. The age range was 3\u201370 years, with mean of 40.75 years. The tumors ranged 2.5\u201313\u2009cm in size, with a mean size of 6.1\u2009cm. One patient had bilateral tumors. All of the tumors were positive for inhibin and calretinin. Four tumors were negative for Mic\u20102 (<jats:styled-content style=\"fixed-case\">CD99<\/jats:styled-content>). In two patients, the tumor recurred. Only one patient who had worse pathological features received adjuvant chemotherapy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Steroid cell tumors are very rare ovarian tumors in the Pakistani population, mostly presenting in adulthood. Diverse histological differentials exist so special stains and immunohistochemical stains are needed to distinguish these from other tumors.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jog.12537","type":"journal-article","created":{"date-parts":[[2014,10,27]],"date-time":"2014-10-27T06:08:30Z","timestamp":1414390110000},"page":"424-431","source":"Crossref","is-referenced-by-count":17,"title":["Ovarian steroid cell tumor, not otherwise specified: A clinicopathological and immunohistochemical experience of 12 cases"],"prefix":"10.1111","volume":"41","author":[{"given":"Saroona","family":"Haroon","sequence":"first","affiliation":[{"name":"Section of Histopathology Department of Pathology and Microbiology Aga Khan University Hospital  Karachi Pakistan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Romana","family":"Idrees","sequence":"additional","affiliation":[{"name":"Section of Histopathology Department of Pathology and Microbiology Aga Khan University Hospital  Karachi 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