{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,28]],"date-time":"2025-05-28T17:24:08Z","timestamp":1748453048728,"version":"3.37.3"},"reference-count":32,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2014,10,20]],"date-time":"2014-10-20T00:00:00Z","timestamp":1413763200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Obstet and Gynaecol"],"published-print":{"date-parts":[[2015,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>The aim of this study was to evaluate two regimens of administration of sustained\u2010release dinoprostone on the need for oxytocin induction of labor.<\/jats:p><\/jats:sec><jats:sec><jats:title>Material and Methods<\/jats:title><jats:p>We carried out an open prospective study comparing labor, maternal and neonatal outcomes after 12\u2009h of prostaglandin cervical ripening insert versus 24\u2009h of prostaglandin cervical ripening insert in 284 patients (142 ripenings at 12\u2009h [<jats:styled-content style=\"fixed-case\">P12<\/jats:styled-content>group] and 142 ripenings at 24\u2009h [<jats:styled-content style=\"fixed-case\">P24<\/jats:styled-content>group]).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The two groups were demographically similar. There was a significant difference in the need for artificial rupture of membranes\/oxytocin induction of labor between the groups (49.3% for the<jats:styled-content style=\"fixed-case\">P12<\/jats:styled-content>group vs 38% for the<jats:styled-content style=\"fixed-case\">P24<\/jats:styled-content>group,<jats:italic>P<\/jats:italic>\u2009=\u20090.03). The delay between the beginning of ripening and delivery was significantly decreased in the<jats:styled-content style=\"fixed-case\">P12<\/jats:styled-content>group, but the duration of active labor (6.6\u2009h), the dose of oxytocics used (1326<jats:styled-content style=\"fixed-case\">UI<\/jats:styled-content>), the rate of cesarean section, the rate of uterine hyperstimulation, the rates of hemorrhaging from delivery, the neonatal state and the experience of induction were similar in the two groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>This study allows us to show for the first time that sustained\u2010release of dinoprostone leads to spontaneous induction of labor without increasing the obstetrical risk in a majority of patients.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jog.12540","type":"journal-article","created":{"date-parts":[[2014,10,21]],"date-time":"2014-10-21T00:41:44Z","timestamp":1413852104000},"page":"370-376","source":"Crossref","is-referenced-by-count":3,"title":["Impact of prolonged dinoprostone cervical ripening on the rate of artificial induction of labor: A prospective study of 330 patients"],"prefix":"10.1111","volume":"41","author":[{"given":"Christine","family":"Denoual\u2010Ziad","sequence":"first","affiliation":[{"name":"Obstetrics and Gynecology Service University of Caen Caen France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"St\u00e9phanie","family":"Aicardi\u2010Nicolas","sequence":"additional","affiliation":[{"name":"Obstetrics and Gynecology Service Hospital of Arcachon Arcachon France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christian","family":"Creveuil","sequence":"additional","affiliation":[{"name":"Biostatistics and Clinical Research Unit University of Caen Caen France"},{"name":"University of Caen Caen France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cathy","family":"Gaillard","sequence":"additional","affiliation":[{"name":"Biostatistics and Clinical Research Unit University of Caen Caen France"},{"name":"University of Caen Caen France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michel","family":"Dreyfus","sequence":"additional","affiliation":[{"name":"Obstetrics and Gynecology Service University of Caen Caen France"},{"name":"University of Caen Caen France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1415-6474","authenticated-orcid":false,"given":"Guillaume","family":"Benoist","sequence":"additional","affiliation":[{"name":"Obstetrics and Gynecology Service University of Caen Caen France"},{"name":"University of Caen Caen France"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2014,10,20]]},"reference":[{"issue":"15","key":"e_1_2_7_2_1","first-page":"8","article-title":"Clinical experience with a controlled\u2010release, prostaglandin E2 intravaginal insert in the USA","volume":"104","author":"Rayburn WF","year":"1997","journal-title":"Br J Obstet Gynaecol"},{"key":"e_1_2_7_3_1","first-page":"638","article-title":"[Survey of the practice of cervical ripening and labor induction in France]","volume":"32","author":"Goffinet F","year":"2003","journal-title":"J Gynecol Obstet Biol Reprod (Paris)"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD003101.pub2"},{"issue":"1","key":"e_1_2_7_5_1","first-page":"89","article-title":"Prostaglandins in preinduction cervical ripening. 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