{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,9]],"date-time":"2026-06-09T07:31:31Z","timestamp":1780990291520,"version":"3.54.1"},"reference-count":47,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2014,10,15]],"date-time":"2014-10-15T00:00:00Z","timestamp":1413331200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Faculty of Medicine Ramathibodi Hospital, Mahidol University"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Obstet and Gynaecol"],"published-print":{"date-parts":[[2015,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>To compare the effects of ethinyl estradiol (<jats:styled-content style=\"fixed-case\">EE<\/jats:styled-content>) 30\u2009mcg\/desogestrel 150\u2009mcg plus spironolactone 25\u2009mg\/day (group <jats:styled-content style=\"fixed-case\">A<\/jats:styled-content>) versus <jats:styled-content style=\"fixed-case\">EE<\/jats:styled-content> 35\u2009mcg\/cyproterone acetate 2\u2009mg (group <jats:styled-content style=\"fixed-case\">B<\/jats:styled-content>) on hyperandrogenism and metabolism in <jats:styled-content style=\"fixed-case\">PCOS<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This was a randomized clinical study. Eighteen women in groups <jats:styled-content style=\"fixed-case\">A<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">B<\/jats:styled-content> received medications for three cycles. Acne score, androgens and metabolic parameters were assessed before and after treatment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>One and two women in groups <jats:styled-content style=\"fixed-case\">A<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">B<\/jats:styled-content>, respectively, were excluded from the study. Both groups had significantly decreased acne score and free androgen index, and increased sex hormone\u2010binding globulin levels. Cholesterol and high\u2010density lipoprotein were significantly increased in group <jats:styled-content style=\"fixed-case\">B<\/jats:styled-content>, and androstenedione was significantly decreased in group <jats:styled-content style=\"fixed-case\">A<\/jats:styled-content>. The regular withdrawal bleeding was obtained in both groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Both regimens had quite similar efficacy on hyperandrogenism after three cycles of therapy and without any changes in metabolic parameters.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jog.12543","type":"journal-article","created":{"date-parts":[[2014,10,15]],"date-time":"2014-10-15T11:07:38Z","timestamp":1413371258000},"page":"402-410","source":"Crossref","is-referenced-by-count":13,"title":["Comparison of desogestrel\/ethinyl estradiol plus spironolactone versus cyproterone acetate\/ethinyl estradiol in the treatment of polycystic ovary syndrome: A randomized controlled trial"],"prefix":"10.1111","volume":"41","author":[{"given":"Supatra","family":"Leelaphiwat","sequence":"first","affiliation":[{"name":"Department of Pathology Faculty of Medicine Ramathibodi Hospital, Mahidol University  Bangkok Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Theerayut","family":"Jongwutiwes","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Faculty of Medicine Ramathibodi Hospital, Mahidol University  Bangkok Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Srithean","family":"Lertvikool","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Faculty of Medicine Ramathibodi Hospital, Mahidol University  Bangkok Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chotika","family":"Tabcharoen","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Faculty of Medicine Ramathibodi Hospital, Mahidol University  Bangkok Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matchuporn","family":"Sukprasert","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Faculty of Medicine Ramathibodi Hospital, Mahidol University  Bangkok Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sasivimol","family":"Rattanasiri","sequence":"additional","affiliation":[{"name":"Research Center Faculty of Medicine Ramathibodi Hospital, Mahidol University  Bangkok Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sawaek","family":"Weerakiet","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Faculty of Medicine Ramathibodi Hospital, Mahidol University  Bangkok Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,10,15]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(07)61345-2"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1210\/jcem.84.11.6148"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/det262"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1210\/er.18.6.774"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0950-351X(96)80085-1"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1529-8019.2006.00077.x"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.2165\/00128071-200708040-00003"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1447-0756.2007.00704.x"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1590\/S0365-05962011000100015"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clindermatol.2009.03.006"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1177\/014107688607900806"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00266-006-0081-0"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.sder.2008.06.002"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-3083.2005.01072.x"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2003.10.004"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.2337\/diacare.24.4.683"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-4362.1997.00099.x"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9378(81)90746-8"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2006-1864"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00280883"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.contraception.2012.09.003"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.3109\/09513590.2013.831834"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.contraception.2011.12.011"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2265.2012.04466.x"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2014-1135"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00404-014-3217-5"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.12432"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0015-0282(02)02993-X"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2003-030328"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bpobgyn.2004.05.007"},{"key":"e_1_2_7_32_1","first-page":"2","article-title":"The effect of 2 combined oral Contraceptives containing either drospirenone or cyproterone acetate on acne and seborrhea","volume":"69","author":"Vloten WA","year":"2002","journal-title":"Cutis"},{"key":"e_1_2_7_33_1","first-page":"123","article-title":"Superiority of a combined contraceptive containing drospirenone to a triphasic preparation containing norgestimate in acne treatment","volume":"74","author":"Thorneycroft H","year":"2004","journal-title":"Cutis"},{"key":"e_1_2_7_34_1","doi-asserted-by":"publisher","DOI":"10.2165\/00044011-200828110-00004"},{"key":"e_1_2_7_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.contraception.2009.02.016"},{"key":"e_1_2_7_36_1","doi-asserted-by":"publisher","DOI":"10.3109\/09546634.2010.519766"},{"key":"e_1_2_7_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0015-0282(97)00427-5"},{"key":"e_1_2_7_38_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12325-008-0039-5"},{"key":"e_1_2_7_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2005.05.051"},{"key":"e_1_2_7_40_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF03346548"},{"key":"e_1_2_7_41_1","doi-asserted-by":"publisher","DOI":"10.1080\/13625180400007751"},{"key":"e_1_2_7_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2005.07.1306"},{"key":"e_1_2_7_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2014.02.039"},{"key":"e_1_2_7_44_1","doi-asserted-by":"publisher","DOI":"10.1159\/000341823"},{"key":"e_1_2_7_45_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF03345529"},{"key":"e_1_2_7_46_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.2000.tb06236.x"},{"key":"e_1_2_7_47_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.contraception.2003.11.003"},{"key":"e_1_2_7_48_1","doi-asserted-by":"publisher","DOI":"10.3109\/00016349009021041"}],"container-title":["Journal of Obstetrics and Gynaecology Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjog.12543","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjog.12543","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jog.12543","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,24]],"date-time":"2023-09-24T07:29:31Z","timestamp":1695540571000},"score":1,"resource":{"primary":{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/10.1111\/jog.12543"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,10,15]]},"references-count":47,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2015,3]]}},"alternative-id":["10.1111\/jog.12543"],"URL":"https:\/\/doi.org\/10.1111\/jog.12543","archive":["Portico"],"relation":{},"ISSN":["1341-8076","1447-0756"],"issn-type":[{"value":"1341-8076","type":"print"},{"value":"1447-0756","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,10,15]]}}}