{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T12:26:58Z","timestamp":1788870418133,"version":"build-2803163510"},"reference-count":48,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2014,10,20]],"date-time":"2014-10-20T00:00:00Z","timestamp":1413763200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Dr. Zekai Tahir Burak Women's Health Care, Education and Research Hospital, Ankara, Turkey"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Obstet and Gynaecol"],"published-print":{"date-parts":[[2015,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>\n                      We aimed to investigate cholecystokinin (\n                      <jats:styled-content style=\"fixed-case\">CCK<\/jats:styled-content>\n                      ) release in pregnant women with and without hyperemesis gravidarum (\n                      <jats:styled-content style=\"fixed-case\">HG<\/jats:styled-content>\n                      ).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Material and Methods<\/jats:title>\n                    <jats:p>\n                      In this case\u2013control study including 40 pregnant women with\n                      <jats:styled-content style=\"fixed-case\">HG<\/jats:styled-content>\n                      and 40 women with healthy uncomplicated pregnancies, serum\n                      <jats:styled-content style=\"fixed-case\">CCK<\/jats:styled-content>\n                      levels in addition to hematological, biochemical and hormonal parameters were investigated.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Serum\n                      <jats:styled-content style=\"fixed-case\">CCK<\/jats:styled-content>\n                      values were found to be significantly lower in pregnant women with\n                      <jats:styled-content style=\"fixed-case\">HG<\/jats:styled-content>\n                      (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u20090.001). Additionally, while serum blood urea nitrogen and free thyroxine levels were significantly higher, sodium, potassium, and thyroid stimulating hormone levels were significantly lower in women with\n                      <jats:styled-content style=\"fixed-case\">HG<\/jats:styled-content>\n                      than in control women. No correlation was detected between\n                      <jats:styled-content style=\"fixed-case\">CCK<\/jats:styled-content>\n                      and other parameters like ketonuria and thyroid function tests.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      <jats:styled-content style=\"fixed-case\">CCK<\/jats:styled-content>\n                      release has been found to be halved in pregnant women with\n                      <jats:styled-content style=\"fixed-case\">HG<\/jats:styled-content>\n                      , which supports the hypothesis that gastrointestinal motility is increased in pregnant women with\n                      <jats:styled-content style=\"fixed-case\">HG<\/jats:styled-content>\n                      . A causal effect remains to be confirmed.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jog.12562","type":"journal-article","created":{"date-parts":[[2014,10,20]],"date-time":"2014-10-20T20:46:23Z","timestamp":1413837983000},"page":"505-511","source":"Crossref","is-referenced-by-count":3,"title":["Disturbed release of cholecystokinin in pregnant women with hyperemesis gravidarum"],"prefix":"10.1111","volume":"41","author":[{"given":"Ebru","family":"Biberoglu","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology High Risk Pregnancy Unit Dr. Zekai Tahir Burak Women's Health Care, Education and Research Hospital Ankara Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ayse","family":"Kirbas","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology High Risk Pregnancy Unit Dr. Zekai Tahir Burak Women's Health Care, Education and Research Hospital Ankara Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cantekin","family":"Iskender","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology High Risk Pregnancy Unit Dr. Zekai Tahir Burak Women's Health Care, Education and Research Hospital Ankara Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aylin","family":"Dirican","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology High Risk Pregnancy Unit Dr. Zekai Tahir Burak Women's Health Care, Education and Research Hospital Ankara Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Halil","family":"Daglar","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology High Risk Pregnancy Unit Dr. Zekai Tahir Burak Women's Health Care, Education and Research Hospital Ankara Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Canan","family":"Demirtas","sequence":"additional","affiliation":[{"name":"Department of Biochemistry Gazi University Medical School Ankara Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beyza","family":"Doganay","sequence":"additional","affiliation":[{"name":"Department of Biostatistics Ankara University Medical School Ankara Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dilek","family":"Uygur","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology High Risk Pregnancy Unit Dr. Zekai Tahir Burak Women's Health Care, Education and Research Hospital Ankara Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kutay","family":"Biberoglu","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Gazi University Medical School Ankara Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,10,20]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bpg.2007.05.005"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1067\/mob.2002.122592"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/humupd\/dmi021"},{"key":"e_1_2_7_5_1","first-page":"1","volume-title":"Cholecystokinin Antagonists in Gastroenterology: Basic and Clinical Status","author":"Bishopa E","year":"1991"},{"key":"e_1_2_7_6_1","doi-asserted-by":"crossref","first-page":"745","DOI":"10.1016\/S0031-6997(24)01427-3","article-title":"International Union of Pharmacology. 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