{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,24]],"date-time":"2025-07-24T12:14:15Z","timestamp":1753359255130},"reference-count":108,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2014,11,3]],"date-time":"2014-11-03T00:00:00Z","timestamp":1414972800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Obstet and Gynaecol"],"published-print":{"date-parts":[[2014,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Developments in immunohistochemistry, which are closely linked with the advances in the analyses of genetic abnormalities and their associated molecular disorders as early and late histogenetic events, have contributed greatly to the improvement of pathological diagnostic confirmation and validation. Immunohistochemistry has also generated great benefit to the innovation of therapeutic strategies for various kinds of cancers. In this article, the three representative histological types of corpus cancer, namely, endometrioid adenocarcinoma, serous adenocarcinoma and clear cell adenocarcinoma, will be histologically approached in association with their immunohistochemical profiles as well as genetic disorders. First, the focus will be on \u2018Conventional\/prototypic features,\u2019 followed by \u2018Controversy over conventional histological subclassification,\u2019 and subsequently \u2018Tumorigenesis and re\u2010subclassification.\u2019<\/jats:p>","DOI":"10.1111\/jog.12564","type":"journal-article","created":{"date-parts":[[2014,11,3]],"date-time":"2014-11-03T08:25:38Z","timestamp":1415003138000},"page":"2167-2176","source":"Crossref","is-referenced-by-count":11,"title":["Immunohistochemical characterization of endometrial carcinomas: Endometrioid, serous and clear cell adenocarcinomas in association with genetic analysis"],"prefix":"10.1111","volume":"40","author":[{"given":"Masanori","family":"Yasuda","sequence":"first","affiliation":[{"name":"Department of Pathology Saitama Medical University International Medical Center  Hidaka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2014,11,3]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-198203000-00002"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/0090-8258(83)90111-7"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2006.06.7173"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0142(20000215)88:4<814::AID-CNCR12>3.0.CO;2-U"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.humpath.2004.02.007"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00428-003-0947-3"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1177\/107327480901600102"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0b013e318247b7bb"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0020-7292(06)60031-3"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1006\/gyno.1999.5505"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjc.6603012"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00428-010-0939-z"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1006\/gyno.2000.5737"},{"key":"e_1_2_7_15_1","first-page":"300","article-title":"Uterine papillary serous carcinoma (pure and mixed type) compared with moderately and poorly differentiated endometrioid carcinoma. A clinicopathologic study","volume":"23","author":"Halperin R","year":"2002","journal-title":"Eur J Gynaecol Oncol"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0360-3016(02)02913-9"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.20645"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0b013e31802ee494"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygyno.2011.07.030"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygyno.2004.08.019"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejso.2010.09.010"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00428-013-1382-8"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0046-8177(98)80002-6"},{"key":"e_1_2_7_24_1","volume-title":"The General Rules for Clinical and Pathological Management of Uterine Corpus Cancer","author":"Japan Society of Obstetrics and Gynecology TJSoP, Japan Radiological Society, Japanese Society for Therapeutic Radiology and Oncology","year":"2012"},{"key":"e_1_2_7_25_1","volume-title":"Treatment Guidelines for Uterine Body Cancer","author":"Gynecology JSoOa","year":"2013"},{"key":"e_1_2_7_26_1","unstructured":"CancerStatistics in Japan\u20102013. [database on the Internet].Foundation for Promotion of Cancer Reserch.2013. [Cited 5 December 2013.] Available from URL:http:\/\/ganjoho.jp\/pro\/statistics\/en\/backnumber\/2013_en.html\/."},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21208"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.MP.0000028573.34289.04"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-200412000-00004"},{"key":"e_1_2_7_30_1","first-page":"3526","article-title":"Beta\u2010catenin mutation in carcinoma of the uterine endometrium","volume":"58","author":"Fukuchi T","year":"1998","journal-title":"Cancer Res"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1038\/modpathol.3880196"},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1349-7006.2003.tb01360.x"},{"key":"e_1_2_7_33_1","first-page":"4736","article-title":"PTEN\/MMAC1 mutations in endometrial cancers","volume":"57","author":"Risinger JI","year":"1997","journal-title":"Cancer Res"},{"key":"e_1_2_7_34_1","first-page":"3935","article-title":"Mutations in PTEN are frequent in endometrial carcinoma but rare in other common gynecological malignancies","volume":"57","author":"Tashiro H","year":"1997","journal-title":"Cancer Res"},{"key":"e_1_2_7_35_1","first-page":"2095","article-title":"Frequent PTEN\/MMAC mutations in endometrioid but not serous or mucinous epithelial ovarian tumors","volume":"58","author":"Obata K","year":"1998","journal-title":"Cancer Res"},{"key":"e_1_2_7_36_1","doi-asserted-by":"publisher","DOI":"10.1006\/gyno.1998.5208"},{"key":"e_1_2_7_37_1","first-page":"47","article-title":"Expression of PTEN and PTEN pseudogene in endometrial carcinoma","volume":"6","author":"Yokoyama Y","year":"2000","journal-title":"Int J Mol Med"},{"key":"e_1_2_7_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0046-8177(00)80244-0"},{"key":"e_1_2_7_39_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-06-1375"},{"key":"e_1_2_7_40_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-05-2620"},{"key":"e_1_2_7_41_1","doi-asserted-by":"publisher","DOI":"10.1002\/1096-9896(2000)9999:9999<::AID-PATH701>3.0.CO;2-2"},{"key":"e_1_2_7_42_1","doi-asserted-by":"publisher","DOI":"10.1053\/hupa.2002.32220"},{"key":"e_1_2_7_43_1","doi-asserted-by":"publisher","DOI":"10.1155\/2004\/391039"},{"key":"e_1_2_7_44_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.pas.0000213428.61374.06"},{"key":"e_1_2_7_45_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0b013e3181971fdd"},{"key":"e_1_2_7_46_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0b013e3181e3291e"},{"key":"e_1_2_7_47_1","doi-asserted-by":"publisher","DOI":"10.1097\/00004347-198903000-00004"},{"key":"e_1_2_7_48_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.2910590505"},{"key":"e_1_2_7_49_1","doi-asserted-by":"publisher","DOI":"10.1080\/00313029600169463"},{"key":"e_1_2_7_50_1","doi-asserted-by":"publisher","DOI":"10.1097\/00004347-200110000-00009"},{"key":"e_1_2_7_51_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(20011115)92:10<2578::AID-CNCR1610>3.0.CO;2-V"},{"key":"e_1_2_7_52_1","doi-asserted-by":"publisher","DOI":"10.2174\/138920211794520169"},{"key":"e_1_2_7_53_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2008.18.6296"},{"key":"e_1_2_7_54_1","doi-asserted-by":"publisher","DOI":"10.1097\/00004347-199701000-00007"},{"key":"e_1_2_7_55_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19820701)50:1<163::AID-CNCR2820500131>3.0.CO;2-K"},{"key":"e_1_2_7_56_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0046-8177(85)80210-0"},{"key":"e_1_2_7_57_1","doi-asserted-by":"publisher","DOI":"10.1038\/modpathol.2013.107"},{"key":"e_1_2_7_58_1","first-page":"267","article-title":"Aberrant DNA hypermethylation of hMLH\u20101 and CDKN2A\/p16 genes in benign, premalignant and malignant endometrial lesions","volume":"30","author":"Guida M","year":"2009","journal-title":"Eur J Gynaecol Oncol"},{"key":"e_1_2_7_59_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-04-2001"},{"key":"e_1_2_7_60_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjc.6602480"},{"key":"e_1_2_7_61_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0925-4773(99)00160-4"},{"key":"e_1_2_7_62_1","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.19.2.1262"},{"key":"e_1_2_7_63_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0378-1119(01)00866-6"},{"key":"e_1_2_7_64_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0b013e3181483ff8"},{"key":"e_1_2_7_65_1","doi-asserted-by":"publisher","DOI":"10.1177\/106689690401200302"},{"key":"e_1_2_7_66_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.pgp.0000228138.56222.4e"},{"key":"e_1_2_7_67_1","doi-asserted-by":"publisher","DOI":"10.1309\/K84K-005F-TCB8-FV4B"},{"key":"e_1_2_7_68_1","doi-asserted-by":"publisher","DOI":"10.1097\/00004347-200404000-00004"},{"key":"e_1_2_7_69_1","doi-asserted-by":"publisher","DOI":"10.1097\/00004347-200404000-00005"},{"key":"e_1_2_7_70_1","doi-asserted-by":"publisher","DOI":"10.1016\/0046-8177(95)90203-1"},{"key":"e_1_2_7_71_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-199504000-00003"},{"key":"e_1_2_7_72_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygyno.2004.12.045"},{"key":"e_1_2_7_73_1","doi-asserted-by":"publisher","DOI":"10.1186\/1746-1596-8-25"},{"key":"e_1_2_7_74_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4419-0489-8"},{"key":"e_1_2_7_75_1","doi-asserted-by":"publisher","DOI":"10.1186\/1746-1596-3-6"},{"key":"e_1_2_7_76_1","first-page":"55","article-title":"Endometrial cancer in polyps: A clinical study of 27 cases","volume":"26","author":"Martin\u2010Ondarza C","year":"2005","journal-title":"Eur J Gynaecol Oncol"},{"key":"e_1_2_7_77_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-07-4837"},{"key":"e_1_2_7_78_1","doi-asserted-by":"publisher","DOI":"10.1002\/path.4056"},{"key":"e_1_2_7_79_1","doi-asserted-by":"publisher","DOI":"10.1002\/path.2911"},{"key":"e_1_2_7_80_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.humpath.2006.12.018"},{"key":"e_1_2_7_81_1","doi-asserted-by":"publisher","DOI":"10.1097\/PGP.0b013e31818e101f"},{"key":"e_1_2_7_82_1","doi-asserted-by":"publisher","DOI":"10.1006\/gyno.1998.5147"},{"key":"e_1_2_7_83_1","doi-asserted-by":"publisher","DOI":"10.1097\/00004347-199501000-00006"},{"key":"e_1_2_7_84_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-199507000-00004"},{"key":"e_1_2_7_85_1","doi-asserted-by":"publisher","DOI":"10.1111\/his.12029"},{"key":"e_1_2_7_86_1","volume-title":"World Health Oganization Classification of Tumours","author":"Tavassoli FA DP","year":"2003"},{"key":"e_1_2_7_87_1","doi-asserted-by":"publisher","DOI":"10.1006\/gyno.2000.5746"},{"key":"e_1_2_7_88_1","doi-asserted-by":"publisher","DOI":"10.1097\/PGP.0b013e3181cd6552"},{"key":"e_1_2_7_89_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0b013e3181ac35f5"},{"key":"e_1_2_7_90_1","doi-asserted-by":"publisher","DOI":"10.1038\/modpathol.3800620"},{"key":"e_1_2_7_91_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2007.08.075"},{"key":"e_1_2_7_92_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.24160"},{"key":"e_1_2_7_93_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajcp\/94.3.247"},{"key":"e_1_2_7_94_1","doi-asserted-by":"publisher","DOI":"10.1097\/00004347-200010000-00006"},{"key":"e_1_2_7_95_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.onc.1202178"},{"key":"e_1_2_7_96_1","doi-asserted-by":"publisher","DOI":"10.1006\/gyno.2000.5858"},{"key":"e_1_2_7_97_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00432-006-0179-4"},{"key":"e_1_2_7_98_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.humpath.2006.05.007"},{"key":"e_1_2_7_99_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-199206000-00008"},{"key":"e_1_2_7_100_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0b013e318202772e"},{"key":"e_1_2_7_101_1","first-page":"121","volume-title":"WHO Classification of Tumours of the Female Reproductive Organs","author":"Zaino R","year":"2014"},{"key":"e_1_2_7_102_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0046-8177(98)90429-4"},{"key":"e_1_2_7_103_1","doi-asserted-by":"publisher","DOI":"10.1006\/exmp.1999.2289"},{"key":"e_1_2_7_104_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0029-7844(02)02391-8"},{"key":"e_1_2_7_105_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-0943-03"},{"key":"e_1_2_7_106_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1525-1438.2006.00406.x"},{"key":"e_1_2_7_107_1","doi-asserted-by":"publisher","DOI":"10.1038\/modpathol.2010.41"},{"key":"e_1_2_7_108_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.pas.0000149704.89463.05"},{"key":"e_1_2_7_109_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature12113"}],"container-title":["Journal of Obstetrics and Gynaecology Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjog.12564","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjog.12564","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jog.12564","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,2]],"date-time":"2023-10-02T17:02:36Z","timestamp":1696266156000},"score":1,"resource":{"primary":{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/10.1111\/jog.12564"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,11,3]]},"references-count":108,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2014,12]]}},"alternative-id":["10.1111\/jog.12564"],"URL":"https:\/\/doi.org\/10.1111\/jog.12564","archive":["Portico"],"relation":{},"ISSN":["1341-8076","1447-0756"],"issn-type":[{"value":"1341-8076","type":"print"},{"value":"1447-0756","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,11,3]]}}}