{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T00:15:24Z","timestamp":1791591324872,"version":"4.3.4"},"reference-count":43,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2014,11,5]],"date-time":"2014-11-05T00:00:00Z","timestamp":1415145600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Japanese Grants-in-Aid for Scientific Research","award":["16790979"],"award-info":[{"award-number":["16790979"]}]},{"name":"Japanese Grants-in-Aid for Scientific Research","award":["25461570"],"award-info":[{"award-number":["25461570"]}]},{"DOI":"10.13039\/100015636","name":"Ishibashi Foundation","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100015636","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Obstet and Gynaecol"],"published-print":{"date-parts":[[2015,4]]},"abstract":"Abstracts<\/jats:title>Aim<\/jats:title>Diminished vasodilator activity during pregnancy, which augments vascular responses to vasoconstrictors, is one reason for the onset of pre\u2010eclampsia and superimposed pre\u2010eclampsia. It is known that D<\/jats:styled-content>ahl salt\u2010sensitive (D<\/jats:styled-content>ahl\u2010S<\/jats:styled-content>) rats develop salt\u2010sensitive hypertension like A<\/jats:styled-content>frican\u2010A<\/jats:styled-content>mericans. The present study attempted to assess the changes and the interactions of the NOS\u2010NO\u2010sGC\u2010cGMP<\/jats:styled-content> and NP\u2010NPR\u2010cGMP<\/jats:styled-content> systems in the hypertensive placenta using D<\/jats:styled-content>ahl\u2010S<\/jats:styled-content> rats as an animal model of superimposed pre\u2010eclampsia.<\/jats:p><\/jats:sec>Material and Methods<\/jats:title>Pregnant Dahl\u2010S<\/jats:styled-content> rats were fed a high\u2010salt diet to induce the development of hypertension and fetal growth restriction. Using these rats, we investigated the regulation of these two vasodilatation systems, including the kinetics of cyclic guanosine monophosphate (cGMP<\/jats:styled-content>), soluble guanylate cyclase (sGC<\/jats:styled-content>), endothelial nitric oxide synthase (NOS<\/jats:styled-content>), cytokine\u2010inducible NOS<\/jats:styled-content>, natriuretic peptides (NP<\/jats:styled-content>) (atrial NP<\/jats:styled-content>, brain NP<\/jats:styled-content> and C\u2010type NP<\/jats:styled-content>), and NP<\/jats:styled-content> receptors (NPR<\/jats:styled-content>) (NPR\u2010A<\/jats:styled-content>, NPR\u2010B<\/jats:styled-content>, NPR\u2010C<\/jats:styled-content>).<\/jats:p><\/jats:sec>Results<\/jats:title>Dahl\u2010S<\/jats:styled-content> rats fed a high\u2010salt diet exhibited hypertension, fetal growth restriction and thickening of the walls in decidual vessels. The placental cGMP<\/jats:styled-content> level in the rats fed the high\u2010salt diet was significantly decreased compared with that in controls. The expression levels of endothelial NOS<\/jats:styled-content> and cytokine\u2010inducible NOS mRNA<\/jats:styled-content> increased significantly, while that of sGC<\/jats:styled-content>\u03b12\u2010sunbnit declined significantly. Messenger RNA<\/jats:styled-content> levels of NPR<\/jats:styled-content>\u2010C<\/jats:styled-content>, a clearance\u2010type receptor of NP<\/jats:styled-content>, declined significantly, whereas those of NP<\/jats:styled-content> and their functional receptors NPR<\/jats:styled-content>\u2010A<\/jats:styled-content> and NPR<\/jats:styled-content>\u2010B<\/jats:styled-content> were unchanged.<\/jats:p><\/jats:sec>Conclusions<\/jats:title>As D<\/jats:styled-content>ahl\u2010S<\/jats:styled-content> rats with excess salt\u2010loading during pregnancy exhibited pathological changes similar to those observed in female humans with pre\u2010eclampsia\/superimposed pre\u2010eclampsia, this rat could be useful as an animal model of superimposed pre\u2010eclampsia. In the placentas of hypertensive D<\/jats:styled-content>ahl\u2010S<\/jats:styled-content> rats, vasodilatation seemed to be disturbed by the deregulation of both the NO\u2010sGC\u2010cGMP<\/jats:styled-content> and NP\u2010NPR\u2010cGMP<\/jats:styled-content> systems.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jog.12602","type":"journal-article","created":{"date-parts":[[2014,11,5]],"date-time":"2014-11-05T10:41:23Z","timestamp":1415184083000},"page":"540-550","source":"Crossref","is-referenced-by-count":15,"title":["Changes in the nitric oxide\u2010soluble guanylate cyclase system and natriuretic peptide receptor system in placentas of pregnant D<\/scp>ahl salt\u2010sensitive rats"],"prefix":"10.1111","volume":"41","author":[{"given":"Sachiyo","family":"Takushima","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology Kurume University School of Medicine Kurume 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