{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,19]],"date-time":"2026-06-19T21:19:19Z","timestamp":1781903959696,"version":"3.54.5"},"reference-count":12,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2014,11,25]],"date-time":"2014-11-25T00:00:00Z","timestamp":1416873600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Obstet and Gynaecol"],"published-print":{"date-parts":[[2015,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Acute fatty liver of pregnancy (<jats:styled-content style=\"fixed-case\">AFLP<\/jats:styled-content>) is a devastating disorder of the maternal liver in the third trimester. Recent studies have demonstrated an association between <jats:styled-content style=\"fixed-case\">AFLP<\/jats:styled-content> and fetal fatty acid oxidation disorders. Here, we report a case of <jats:styled-content style=\"fixed-case\">AFLP<\/jats:styled-content> caused by fetal mitochondrial trifunctional protein (<jats:styled-content style=\"fixed-case\">TFP<\/jats:styled-content>) deficiency. A 21\u2010year\u2010old parous woman presented with nausea, genital bleeding and abdominal pain at 33\u2009weeks of gestation. Laboratory data revealed hepatic failure and disseminated intravascular coagulopathy. The patient underwent emergency cesarean section and was diagnosed with <jats:styled-content style=\"fixed-case\">AFLP<\/jats:styled-content> from the clinical characteristics. She was successfully treated with frequent plasma exchange. The newborn presented severe heart failure and died on the 39th day after birth. Tandem mass spectrometry indicated long\u2010chain fatty acid oxidation disorder. Gene analysis demonstrated homozygous mutation in exon 13 of <jats:italic><jats:styled-content style=\"fixed-case\">HADHB<\/jats:styled-content><\/jats:italic>, the gene responsible for mitochondrial <jats:styled-content style=\"fixed-case\">TFP<\/jats:styled-content> deficiency. The parents carried a heterozygous mutation at the same location in <jats:italic><jats:styled-content style=\"fixed-case\">HADHB<\/jats:styled-content><\/jats:italic>.<\/jats:p>","DOI":"10.1111\/jog.12609","type":"journal-article","created":{"date-parts":[[2014,11,25]],"date-time":"2014-11-25T08:19:19Z","timestamp":1416903559000},"page":"799-802","source":"Crossref","is-referenced-by-count":14,"title":["Acute fatty liver of pregnancy associated with fetal mitochondrial trifunctional protein deficiency"],"prefix":"10.1111","volume":"41","author":[{"given":"Tomoko","family":"Kobayashi","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology Wakayama Medical University  Wakayama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sawako","family":"Minami","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Wakayama Medical University  Wakayama 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