{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,4]],"date-time":"2025-10-04T08:00:55Z","timestamp":1759564855270,"version":"3.37.3"},"reference-count":41,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2014,12,16]],"date-time":"2014-12-16T00:00:00Z","timestamp":1418688000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001700","name":"Ministry of Education, Science, Culture and Sports, Japan","doi-asserted-by":"crossref","award":["25462554","25670490","24390273"],"award-info":[{"award-number":["25462554","25670490","24390273"]}],"id":[{"id":"10.13039\/501100001700","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Obstet and Gynaecol"],"published-print":{"date-parts":[[2015,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>To measure cerebral tissue hemoglobin in uncomplicated and complicated pregnant women during the peripartum period.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Time\u2010resolved spectroscopy (<jats:styled-content style=\"fixed-case\">TRS<\/jats:styled-content>\u201020) can measure absolute concentration of oxygenated, deoxygenated, and total tissue hemoglobin based on the transit time of individual photons. Therefore, we used <jats:styled-content style=\"fixed-case\">TRS<\/jats:styled-content>\u201020 to measured tissue hemoglobin in the hemi\u2010prefrontal lobes of normotensive pregnant women with (<jats:italic>n<\/jats:italic>\u2009=\u200951) or without (<jats:italic>n<\/jats:italic>\u2009=\u200919) epidural anesthesia, hypertensive pregnant women with pre\u2010eclampsia (<jats:italic>n<\/jats:italic>\u2009=\u200910), a pregnant woman with acute onset of hypertension soon after delivery, and a hypertensive woman after hemorrhagic stroke in delivery.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Cyclic labor concomitant with intra\u2010abdominal pressure caused synergistic elevation in cerebral tissue hemoglobin. In contrast, epidural anesthesia reduced the amplitude of the cyclic increase of cerebral tissue hemoglobin in normotensive pregnant women. Hypertension in labor due to pre\u2010eclampsia increased the amplitude of synergistic elevation of cerebral tissue hemoglobin caused by cyclic labor and intra\u2010abdominal pressure. A prolonged high basal level of cerebral tissue hemoglobin was observed in a case of acute onset of hypertension soon after delivery. A decrease in cerebral tissue hemoglobin in the hemi\u2010prefrontal lobe was observed in a woman 2\u2009h after the onset of hemorrhagic stroke in labor.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p><jats:styled-content style=\"fixed-case\">TRS<\/jats:styled-content>\u201020 can detect specific changes in maternal cerebral tissue hemoglobin level in response to physiological and pathophysiological changes in delivery. Thus, it represents a promising new conventional tool for maternal cerebral monitoring in the peripartum period.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jog.12639","type":"journal-article","created":{"date-parts":[[2014,12,16]],"date-time":"2014-12-16T08:27:18Z","timestamp":1418718438000},"page":"876-883","source":"Crossref","is-referenced-by-count":4,"title":["Measurement of maternal cerebral tissue hemoglobin on near\u2010infrared time\u2010resolved spectroscopy in the peripartum period"],"prefix":"10.1111","volume":"41","author":[{"given":"Kazunao","family":"Suzuki","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology Hamamatsu University School of Medicine  Hamamatsu Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroaki","family":"Itoh","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Hamamatsu University School of Medicine  Hamamatsu Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mari","family":"Mukai","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Hamamatsu University School of Medicine  Hamamatsu Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kaori","family":"Yamazaki","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Hamamatsu University School of Medicine  Hamamatsu Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Toshiyuki","family":"Uchida","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Hamamatsu University School of Medicine  Hamamatsu Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hideki","family":"Maeda","sequence":"additional","affiliation":[{"name":"Hamamatsu Photonics  Hamamatsu Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Motoki","family":"Oda","sequence":"additional","affiliation":[{"name":"Hamamatsu Photonics  Hamamatsu Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Etsuko","family":"Yamaki","sequence":"additional","affiliation":[{"name":"Hamamatsu Photonics  Hamamatsu Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroaki","family":"Suzuki","sequence":"additional","affiliation":[{"name":"Hamamatsu Photonics  Hamamatsu Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Naohiro","family":"Kanayama","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Hamamatsu University School of Medicine  Hamamatsu Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2014,12,16]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0029-7844(02)02587-5"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.AOG.0000187894.71913.e8"},{"key":"e_1_2_7_4_1","first-page":"1164","volume-title":"Williams Obstetrics","author":"Cunningham FG","year":"2010"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1747-4949.2012.00853.x"},{"key":"e_1_2_7_6_1","first-page":"858134","article-title":"Preeclampsia and stroke: Risks during and after pregnancy","volume":"2011","author":"Bushnell C","year":"2011","journal-title":"Stroke Res Treat"},{"key":"e_1_2_7_7_1","first-page":"161","article-title":"Maternal deaths at King Edward VIII Hospital, Durban. 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