{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T23:45:23Z","timestamp":1790120723859,"version":"4.0.1"},"reference-count":30,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2014,12,16]],"date-time":"2014-12-16T00:00:00Z","timestamp":1418688000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["81170590"],"award-info":[{"award-number":["81170590"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["81200432"],"award-info":[{"award-number":["81200432"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Obstet and Gynaecol"],"published-print":{"date-parts":[[2015,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>We aimed to study the relation between <jats:styled-content style=\"fixed-case\">W<\/jats:styled-content>nt\/\u03b2\u2010catenin signaling pathway and recurrent spontaneous abortion through investigating the expression of \u03b2\u2010catenin and <jats:styled-content style=\"fixed-case\">D<\/jats:styled-content>ickkof\u20101 in first\u2010trimester villi and decidua of recurrent spontaneous abortion patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Material and Methods<\/jats:title><jats:p>Villous and decidual tissues were collected from 40 women (20 patients with recurrent spontaneous abortion and 20 patients with normal, early pregnancy). Western blots were used to measure the protein levels of \u03b2\u2010catenin in villi and decidua, and the localization of \u03b2\u2010catenin was investigated by immunohistochemistry. Quantitative real\u2010time reverse transcription polymerase chain reaction was used to quantify the <jats:styled-content style=\"fixed-case\">mRNA<\/jats:styled-content> levels of \u03b2\u2010catenin and <jats:styled-content style=\"fixed-case\">D<\/jats:styled-content>ickkof\u20101 in villi and decidua, respectively.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Our results indicated that \u03b2\u2010catenin was expressed predominantly in plasma membranes of the villous cytotrophoblasts and glandular epithelium. What's more, its expression significantly decreased at both <jats:styled-content style=\"fixed-case\">mRNA<\/jats:styled-content> and protein levels, whereas the <jats:styled-content style=\"fixed-case\">mRNA<\/jats:styled-content> levels of <jats:styled-content style=\"fixed-case\">D<\/jats:styled-content>ickkof\u20101 significantly increased in villi and decidua of the recurrent spontaneous abortion group compared with the normal control group.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>We therefore speculated that the downregulated <jats:styled-content style=\"fixed-case\">W<\/jats:styled-content>nt\/\u03b2\u2010catenin signaling pathway might be associated with the process of the pathogenesis of recurrent spontaneous abortion.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jog.12647","type":"journal-article","created":{"date-parts":[[2014,12,16]],"date-time":"2014-12-16T08:06:03Z","timestamp":1418717163000},"page":"904-911","source":"Crossref","is-referenced-by-count":19,"title":["Decreased \u03b2\u2010catenin expression in first\u2010trimester villi and decidua of patients with recurrent spontaneous abortion"],"prefix":"10.1111","volume":"41","author":[{"given":"Shuhong","family":"Li","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology Provincial Hospital Affiliated to Shandong University  Jinan China"},{"name":"Department of Obstetrics and Gynecology Yantai Yuhuangding Hospital  Yantai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ning","family":"Li","sequence":"additional","affiliation":[{"name":"Central Laboratory Yantai Yuhuangding Hospital  Yantai 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