{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,10,2]],"date-time":"2023-10-02T06:41:54Z","timestamp":1696228914795},"reference-count":15,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2014,12,16]],"date-time":"2014-12-16T00:00:00Z","timestamp":1418688000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Obstet and Gynaecol"],"published-print":{"date-parts":[[2015,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>\u03b1\u00b0\u2010thalassemia is a well\u2010known cause of hydrops fetalis in <jats:styled-content style=\"fixed-case\">S<\/jats:styled-content>outh\u2010<jats:styled-content style=\"fixed-case\">E<\/jats:styled-content>ast <jats:styled-content style=\"fixed-case\">A<\/jats:styled-content>sia and can be detected <jats:italic>in utero<\/jats:italic>. We report a very rare case of thyrotoxic cardiomyopathy associated with hyperplacentosis secondary to \u03b1\u00b0\u2010thalassemia\u2010associated hydrops fetalis. A 22\u2010year\u2010old primigravida with microcytic anemia presented at 27 weeks' gestation with pre\u2010eclampsia, hyperthyroidism and cardiac failure. Serum \u03b2\u2010human chorionic gonadotrophin was markedly elevated and abdominal ultrasound revealed severe hydropic features and enlarged placenta. Serum \u03b2\u2010human chorionic gonadotrophin, cardiac function and thyroid function tests normalized after she delivered a macerated stillbirth. Histopathology of the placenta showed hyperplacentosis. Blood <jats:styled-content style=\"fixed-case\">DNA<\/jats:styled-content> analysis revealed that both patient and husband have the \u03b1\u00b0\u2010thalassemia trait. This case illustrates a very atypical presentation of \u03b1\u00b0\u2010thalassemia\u2010associated hydrops fetalis and the importance of early prenatal diagnosis of \u03b1\u2010thalassemia in women of relevant ethnic origin with microcytic anemia so that appropriate genetic counseling can be provided to reduce maternal morbidity and the incidence of hydrops fetalis.<\/jats:p>","DOI":"10.1111\/jog.12648","type":"journal-article","created":{"date-parts":[[2014,12,16]],"date-time":"2014-12-16T08:06:41Z","timestamp":1418717201000},"page":"967-970","source":"Crossref","is-referenced-by-count":0,"title":["\u03b1\u2010thalassemia\u2010associated hydrops fetalis: A rare cause of thyrotoxic cardiomyopathy"],"prefix":"10.1111","volume":"41","author":[{"given":"Nor Rafeah","family":"Tumian","sequence":"first","affiliation":[{"name":"Hematology Unit Department of Medicine Universiti Kebangsaan Malaysia Medical Centre  Kuala Lumpur Malaysia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ming","family":"Wong","sequence":"additional","affiliation":[{"name":"Hematology Unit Department of Medicine Universiti Kebangsaan Malaysia Medical Centre  Kuala Lumpur Malaysia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chieh Lee","family":"Wong","sequence":"additional","affiliation":[{"name":"Hematology Unit Department of Medicine Universiti Kebangsaan Malaysia Medical Centre  Kuala Lumpur Malaysia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2014,12,16]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"crossref","first-page":"2213","DOI":"10.1182\/blood.V91.7.2213","article-title":"Hydrops fetalis caused by \u03b1\u2010thalassemia \u2013 an emerging health care problem","volume":"91","author":"Chui DHK","year":"1998","journal-title":"Blood"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-0528.1992.tb13703.x"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0828-282X(10)70367-6"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9378(11)91565-8"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/00003081-199703000-00006"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1210\/jcem-67-1-74"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.4061\/2011\/142413"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1089\/thy.1995.5.425"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1089\/10507250152039154"},{"key":"e_1_2_6_11_1","first-page":"175","volume-title":"Dewhurst's Textbook of Obstetrics and Gynecology for Post\u2010Graduates","author":"Davey DA","year":"1995"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1159\/000305096"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/pd.2128"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1159\/000093887"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1520-6661(199809\/10)7:5<227::AID-MFM3>3.0.CO;2-I"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejogrb.2005.10.024"}],"container-title":["Journal of Obstetrics and Gynaecology Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjog.12648","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjog.12648","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jog.12648","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,1]],"date-time":"2023-10-01T21:38:33Z","timestamp":1696196313000},"score":1,"resource":{"primary":{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/10.1111\/jog.12648"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,12,16]]},"references-count":15,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2015,6]]}},"alternative-id":["10.1111\/jog.12648"],"URL":"https:\/\/doi.org\/10.1111\/jog.12648","archive":["Portico"],"relation":{},"ISSN":["1341-8076","1447-0756"],"issn-type":[{"value":"1341-8076","type":"print"},{"value":"1447-0756","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,12,16]]}}}