{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,23]],"date-time":"2025-10-23T11:09:20Z","timestamp":1761217760628},"reference-count":27,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2014,12,29]],"date-time":"2014-12-29T00:00:00Z","timestamp":1419811200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Obstet and Gynaecol"],"published-print":{"date-parts":[[2015,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>The intracerebral antioxidant ability of mature rats after neonatal hypoxic\u2013ischemic (<jats:styled-content style=\"fixed-case\">HI<\/jats:styled-content>) brain injury was estimated using the microdialysis\u2013electron spin resonance method.<\/jats:p><\/jats:sec><jats:sec><jats:title>Material and Methods<\/jats:title><jats:p>Seven\u2010day\u2010old <jats:styled-content style=\"fixed-case\">W<\/jats:styled-content>istar rats were subjected to a modified <jats:styled-content style=\"fixed-case\">L<\/jats:styled-content>evine's procedure for producing <jats:styled-content style=\"fixed-case\">HI<\/jats:styled-content> brain injury. After <jats:styled-content style=\"fixed-case\">HI<\/jats:styled-content> insult, pups were returned and reared with their dams. Seven weeks after <jats:styled-content style=\"fixed-case\">HI<\/jats:styled-content> insult, their intracerebral antioxidant abilities were measured using the microdialysis\u2013electron spin resonance method after the intraperitoneal injection of 3\u2010methoxycarbonyl\u20102,2,5,5\u2010tetramethylpyrrolidine\u20101\u2010oxyl. Ascorbic acid, <jats:styled-content style=\"fixed-case\">L<\/jats:styled-content>\u2010cysteine, and glutathione (<jats:styled-content style=\"fixed-case\">GSH<\/jats:styled-content>) were also determined. The rats without <jats:styled-content style=\"fixed-case\">HI<\/jats:styled-content> insult were used as a control.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The decay rate of 3\u2010methoxycarbonyl\u20102,2,5,5\u2010tetramethylpyrrolidine\u20101\u2010oxyl in the non\u2010ligated side of the cerebral hemisphere of the <jats:styled-content style=\"fixed-case\">HI<\/jats:styled-content> group was significantly larger than that of the control group. The amounts of ascorbic acid in the perfusate from the non\u2010ligated side of the <jats:styled-content style=\"fixed-case\">HI<\/jats:styled-content> group were about four times larger than those of the control group. The amounts of <jats:styled-content style=\"fixed-case\">L<\/jats:styled-content>\u2010cysteine and <jats:styled-content style=\"fixed-case\">GSH<\/jats:styled-content> of the <jats:styled-content style=\"fixed-case\">HI<\/jats:styled-content> group were about 10 times larger than those of the control group.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The antioxidant ability in the non\u2010ligated sides of the cerebral hemispheres of the mature rats 7 weeks after neonatal <jats:styled-content style=\"fixed-case\">HI<\/jats:styled-content> insult was higher than that of the control group. Higher amounts of ascorbic acid and <jats:styled-content style=\"fixed-case\">GSH<\/jats:styled-content> supported the higher antioxidant ability. The increase of the intracerebral antioxidant ability of the non\u2010ligated side indicates the compensation of motor function for the lost side. The present results should offer important insights into the prognosis for hypoxic\u2013ischemic encephalopathy.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jog.12660","type":"journal-article","created":{"date-parts":[[2014,12,29]],"date-time":"2014-12-29T15:22:14Z","timestamp":1419866534000},"page":"884-889","source":"Crossref","is-referenced-by-count":3,"title":["Intracerebral antioxidant ability of mature rats after neonatal hypoxic\u2013ischemic brain injury estimated using the microdialysis\u2013electron spin resonance method"],"prefix":"10.1111","volume":"41","author":[{"given":"Akira","family":"Nakajima","sequence":"first","affiliation":[{"name":"Section of Obstetrics and Gynecology Department of Reproductive and Developmental Medicine Faculty of Medicine University of Miyazaki  Miyazaki Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuto","family":"Ueda","sequence":"additional","affiliation":[{"name":"Section of Psychiatry Department of Clinical Neuroscience 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