{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T18:30:53Z","timestamp":1761676253392},"reference-count":21,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2015,3,15]],"date-time":"2015-03-15T00:00:00Z","timestamp":1426377600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Task Force for Women in Department of Biotechnology"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Obstet and Gynaecol"],"published-print":{"date-parts":[[2015,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>The aim of our study was to examine the association of low pregnancy\u2010associated plasma protein\u2010<jats:styled-content style=\"fixed-case\">A<\/jats:styled-content> (<jats:styled-content style=\"fixed-case\">PAPP\u2010A<\/jats:styled-content>) with adverse pregnancy outcome.<\/jats:p><\/jats:sec><jats:sec><jats:title>Material and Methods<\/jats:title><jats:p>A total of 1640 consecutive pregnant women between 9<jats:sup>+5<\/jats:sup> and 13<jats:sup>+6<\/jats:sup> weeks of pregnancy were recruited. One hundred and thirty women with <jats:styled-content style=\"fixed-case\">PAPP\u2010A<\/jats:styled-content> levels\u2009&lt;\u20090.4 multiple of median were followed till delivery and the outcome information was obtained for fetal loss, birthweight, growth restriction, preterm birth, reduced liquor and development of pre\u2010eclampsia.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>During the study period, 130 (7.92%) women had low <jats:styled-content style=\"fixed-case\">PAPP\u2010A<\/jats:styled-content> and were considered as cases and 200 women with normal <jats:styled-content style=\"fixed-case\">PAPP\u2010A<\/jats:styled-content> were controls. Intrauterine growth restriction was observed in 28 (21.54%) cases as compared to 10 (5%) controls. Pre\u2010eclampsia presented in 24 (18.46%) cases and in 18 (9%) controls. Twenty (15.38%) cases had preterm delivery compared to 12 (6%) controls. Fifty\u2010six (43.08%) cases delivered low\u2010birthweight babies compared to 22 (11%) controls. Thus, the incidence of intrauterine growth restriction, preterm birth and low birthweight was significantly more in the cases as compared to the control group.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p><jats:styled-content style=\"fixed-case\">PAPP\u2010A<\/jats:styled-content> is a valuable analyte for predicting risk of adverse pregnancy outcome and women with low serum <jats:styled-content style=\"fixed-case\">PAPP\u2010A<\/jats:styled-content> levels would benefit from closer surveillance.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jog.12662","type":"journal-article","created":{"date-parts":[[2015,3,16]],"date-time":"2015-03-16T03:52:49Z","timestamp":1426477969000},"page":"1003-1008","source":"Crossref","is-referenced-by-count":15,"title":["Adverse pregnancy outcome in patients with low pregnancy\u2010associated plasma protein\u2010<scp>A<\/scp>: The <scp>I<\/scp>ndian <scp>E<\/scp>xperience"],"prefix":"10.1111","volume":"41","author":[{"given":"Sangeeta","family":"Gupta","sequence":"first","affiliation":[{"name":"Division of Fetal Medicine Department of Obstetrics &amp; Gynecology Maulana Azad Medical College  New Delhi India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Manisha","family":"Goyal","sequence":"additional","affiliation":[{"name":"Division of Genetics &amp; Metabolism Department of Pediatrics Maulana Azad Medical College  New Delhi India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Deepti","family":"Verma","sequence":"additional","affiliation":[{"name":"Department of Obstetrics &amp; Gynecology Maulana Azad Medical College  New Delhi India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anjana","family":"Sharma","sequence":"additional","affiliation":[{"name":"Division of Genetics &amp; Metabolism Department of Pediatrics Maulana Azad Medical College  New Delhi India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Namita","family":"Bharadwaj","sequence":"additional","affiliation":[{"name":"Division of Genetics &amp; Metabolism Department of Pediatrics Maulana Azad Medical College  New Delhi India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Madhulika","family":"Kabra","sequence":"additional","affiliation":[{"name":"Division of Genetics Department Of Pediatrics All India Institute Of Medical Sciences  New Delhi India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seema","family":"Kapoor","sequence":"additional","affiliation":[{"name":"Division of Genetics &amp; 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