{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,13]],"date-time":"2025-09-13T16:21:19Z","timestamp":1757780479524},"reference-count":27,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2015,3,21]],"date-time":"2015-03-21T00:00:00Z","timestamp":1426896000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Obstet and Gynaecol"],"published-print":{"date-parts":[[2015,7]]},"abstract":"Abstract<\/jats:title>Aim<\/jats:title>The correlation between interleukin\u20106 (IL<\/jats:styled-content>\u20106) gene polymorphism and polycystic ovary syndrome (PCOS<\/jats:styled-content>) has been reported, but the conclusions are controversial. The present study was aimed to evaluate the association between IL<\/jats:styled-content>\u20106 \u2212174 G<\/jats:styled-content>\/C<\/jats:styled-content> polymorphism and susceptibility of PCOS<\/jats:styled-content> by meta\u2010analysis.<\/jats:p><\/jats:sec>Material and Methods<\/jats:title>A systematic search on M<\/jats:styled-content>edline, E<\/jats:styled-content>mbase, CNKI<\/jats:styled-content>, W<\/jats:styled-content>anfang D<\/jats:styled-content>ata and VIP<\/jats:styled-content> databases containing C<\/jats:styled-content>hinese and E<\/jats:styled-content>nglish studies was conducted electronically using specific eligibility criteria. Meta\u2010analysis was performed using R<\/jats:styled-content>eview M<\/jats:styled-content>anager 5.2 software after H<\/jats:styled-content>ardy\u2013W<\/jats:styled-content>einberg equilibrium test. Effect sizes of odds ratio and 95% confidence interval (CI<\/jats:styled-content>) were calculated and combined appropriately. To verify the reliability of the results, subgroup analyses and sensitivity analyses were performed.<\/jats:p><\/jats:sec>Results<\/jats:title>Four selected studies containing 351 cases and 464 control participants were included. The pooled odds ratio between IL<\/jats:styled-content>\u20106 \u2212174 G<\/jats:styled-content>\/C<\/jats:styled-content> polymorphism and susceptibility of PCOS<\/jats:styled-content> under allele (C\/G<\/jats:styled-content>), dominant (CC<\/jats:styled-content>+GC<\/jats:styled-content>\/GG<\/jats:styled-content>) and recessive (CC<\/jats:styled-content>\/GG<\/jats:styled-content>+GC<\/jats:styled-content>) models were 0.63 (95%CI, 0.41\u20130.96), 0.53 (95%CI, 0.26\u20131.08) and 0.67 (95%CI, 0.39\u20131.16), respectively. The result under allele model was unstable in sensitivity analysis. Subgroup analysis showed that the correlation between IL\u20106 \u2013174 G\/C<\/jats:styled-content> polymorphism and susceptibility of PCOS<\/jats:styled-content> was not statistically significant in the studies that conformed to the H<\/jats:styled-content>ardy\u2013W<\/jats:styled-content>einberg equilibrium.<\/jats:p><\/jats:sec>Conclusion<\/jats:title>IL\u20106 \u2013174 G\/C<\/jats:styled-content> polymorphism may be not related to susceptibility of PCOS<\/jats:styled-content>. Nevertheless, further studies with large samples and studies considering other single\u2010nucleotide polymorphisms of the IL<\/jats:styled-content>\u20106 gene are needed to confirm our findings.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jog.12682","type":"journal-article","created":{"date-parts":[[2015,3,24]],"date-time":"2015-03-24T17:37:29Z","timestamp":1427218649000},"page":"1087-1092","source":"Crossref","is-referenced-by-count":7,"title":["Meta\u2010analysis of the correlation between IL<\/scp>\u20106 \u2013174 G\/C<\/scp> polymorphism and polycystic ovarian syndrome"],"prefix":"10.1111","volume":"41","author":[{"given":"Qiongyao","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Gynaecology and Obstetrics Shanghai Tongji Hospital, Tongji University School of Medicine Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaowen","family":"Tong","sequence":"additional","affiliation":[{"name":"Department of Gynaecology and Obstetrics Shanghai Tongji Hospital, Tongji University School of Medicine Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yazhong","family":"Ji","sequence":"additional","affiliation":[{"name":"Department of Assisted Reproduction Shanghai Tongji Hospital Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Huaifang","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Gynaecology and Obstetrics Shanghai Tongji Hospital, Tongji University School of Medicine Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wei","family":"Lu","sequence":"additional","affiliation":[{"name":"Department of Gynaecology and Obstetrics Shanghai Tongji Hospital, Tongji University School of Medicine Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhijiao","family":"Song","sequence":"additional","affiliation":[{"name":"Department of Gynaecology and Obstetrics Shanghai Tenth People's Hospital University School of Medicine Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2015,3,21]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2009-2724"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrendo.2010.217"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/humupd\/dmr025"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1590\/S0100-879X2010007500152"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1093\/gerona\/61.6.575"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10815-013-0111-1"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1744-313X.2009.00867.x"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF03345614"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2010.11.036"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0030-1262855"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejogrb.2010.02.010"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2004.01.021"},{"key":"e_1_2_7_14_1","first-page":"312","article-title":"Interrelationships between immune and reproductive systems in human","volume":"4","author":"Sukhikh G","year":"1999","journal-title":"Russ J Immunol"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1006\/cyto.2002.1959"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gene.2012.04.075"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0076810"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10067-010-1640-y"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00296-013-2855-4"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11010-009-0293-0"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00134-006-0327-y"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mrrev.2011.06.002"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0018480"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-127-9-199711010-00008"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0059421"},{"key":"e_1_2_7_26_1","doi-asserted-by":"crossref","first-page":"1529","DOI":"10.4049\/jimmunol.141.5.1529","article-title":"Regulation of BSF\u20102\/IL\u20106 production by human mononuclear cells. 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